Results 71 to 80 of about 9,856 (174)
Journal for ImmunoTherapy of CancerImmune checkpoint blockade, which enhances the reactivity of T cells to eliminate cancer cells, has emerged as a potent strategy in cancer therapy. Besides T cells, natural killer (NK) cells also play an indispensable role in tumor surveillance and ...
Yan Li +8 more
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NKG2A and the functional competence of liver natural killer cells
The FASEB Journal, 2008 The liver is a unique environment that maintains tolerance to a heavy load of foreign antigens derived from the intestine. The liver is also the site of several chronic viral infections, including hepatitis B & C viruses.
Matthew G. Lassen, Young S. Hahn
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Safety and Feasibility of Blockade of NK Group-2 Member-A Receptor in Natural Killer Cells Combined with Cetuximab Antibody in Patients with Advanced Gastric Adenocarcinoma [PDF]
Advanced Pharmaceutical BulletinPurpose: Blocking of inhibitory receptors such as NK group-2 member-A (NKG2A) enhances tumor immunity of natural killer (NK) cells. Additionally, antibody-dependent cellular cytotoxicity (ADCC) is an important cytotoxic modality of action of NK cells ...
Maryam Samareh-Salavatipour +10 more
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PLoS ONE, 2011 ObjectiveTNF inhibitors (TNFi) have revolutionised the treatment of rheumatoid arthritis (RA). Natural killer (NK) cells and Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose activity is tightly regulated through ...
Ceara E Walsh +8 more
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Clinical & Translational ImmunologyObjectives Immunotherapies targeting natural killer (NK) cell receptors have shown promise against leukaemia. Unfortunately, cancer immunosuppressive mechanisms that alter NK cell phenotype prevent such approaches from being successful.
Cui Tu +8 more
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Frontiers in Veterinary ScienceAlpacas belong to the Camelidae family. Antibodies produced through alpaca immunization are called nanoantibodies. Compared to traditional antibodies, nanoantibodies have several characteristics, including smaller molecular weight, stable structure, high
Xiang Guo +10 more
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Increased proliferative response of highly differentiated CD57+NKG2C+NK cells expressing NKG2A
Медицинская иммунологияDuring infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon ...
N. A. Alekseeva +2 more
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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
Nature Communications, 2019 Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell ...
Branca I. Pereira +15 more
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Torque teno viruses exhaust and imprint the human immune system via the HLA-E/NKG2A axis
Frontiers in ImmunologyThe ubiquitous Torque teno virus (TTV) establishes a chronically persistent infection in the human host. TTV has not been associated with any apparent disease, but, as part of the human virome, it may confer a regulatory imprint on the human immune ...
Hannes Vietzen +10 more
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AntibodiesImmuno-oncology has revolutionized cancer treatment, with NKG2A emerging as a novel target for immunotherapy. The blockade of NKG2A using the immune checkpoint inhibitor (ICI) monalizumab has been shown to enhance the responses of both NK cells and CD8 ...
Yaqiong Zhou +13 more
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