Results 71 to 80 of about 10,258 (173)

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, Volume 10, Issue 18, 23 September 2026.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

NKG2A and COVID-19: another brick in the wall [PDF]

Cellular & Molecular Immunology, 2020
Antonioli L., Fornai M., Pellegrini C., Blandizzi C.   +3 more
openaire   +3 more sources

NKG2A and the functional competence of liver natural killer cells

The FASEB Journal, 2008
The liver is a unique environment that maintains tolerance to a heavy load of foreign antigens derived from the intestine. The liver is also the site of several chronic viral infections, including hepatitis B & C viruses.
Matthew G. Lassen, Young S. Hahn
openaire   +1 more source

A Novel Prognostic Nomogram Based on TIGIT and NKG2A Can Predict Relapse‐Free Survival of Hepatocellular Carcinoma After Hepatectomy

Cancer Medicine
Background and Objectives Hepatocellular carcinoma (HCC) is a major global health concern, and emerging evidence suggests that TIGIT and NKG2A are potential immune checkpoints with implications for HCC progression.
Junqi Wang, Yuqing Cao, Yu Tian, Chaoliu Dai, Tianqiang Jin, Feng Xu   +5 more
doaj   +1 more source

Unlocking the therapeutic potential of the NKG2A-HLA-E immune checkpoint pathway in T cells and NK cells for cancer immunotherapy

Journal for ImmunoTherapy of Cancer
Immune checkpoint blockade, which enhances the reactivity of T cells to eliminate cancer cells, has emerged as a potent strategy in cancer therapy. Besides T cells, natural killer (NK) cells also play an indispensable role in tumor surveillance and ...
Yan Li, Patrick P C Boor, Dave Sprengers, Zhu Li, Sonja Buschow, Yisen Tang, Xiaomei Zhuang, Wanhua Feng, Guoying Zhou   +8 more
doaj   +1 more source

Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis

Clinical & Translational Immunology
Objectives Immunotherapies targeting natural killer (NK) cell receptors have shown promise against leukaemia. Unfortunately, cancer immunosuppressive mechanisms that alter NK cell phenotype prevent such approaches from being successful.
Cui Tu, Irina Buckle, Ingrid Leal Rojas, Gustavo Rodrigues Rossi, David P Sester, Andrew S Moore, Kristen Radford, Camille Guillerey, Fernando Souza‐Fonseca‐Guimaraes   +8 more
doaj   +1 more source

A novel NKG2A alpaca nanobody targeting immune checkpoint blockade for the treatment of malignant melanoma

Frontiers in Veterinary Science
Alpacas belong to the Camelidae family. Antibodies produced through alpaca immunization are called nanoantibodies. Compared to traditional antibodies, nanoantibodies have several characteristics, including smaller molecular weight, stable structure, high
Xiang Guo, Xiang Guo, Xiang Guo, Congfang Guo, Dongxiao Li, Yuting Bai, Mureed Abbas, Mureed Abbas, Ruiwen Fan, Yiyan Zhao, Yiyan Zhao   +10 more
doaj   +1 more source

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Nature Communications, 2019
Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell ...
Branca I. Pereira, Oliver P. Devine, Milica Vukmanovic-Stejic, Emma S. Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J. Sebire, Veronica Kinsler, Alexis Valdovinos, Claude Jourdan LeSaux, João F. Passos, Antony Antoniou, Malcom H. A. Rustin, Judith Campisi, Arne N. Akbar   +15 more
doaj   +1 more source

Increased proliferative response of highly differentiated CD57⁺NKG2C⁺NK cells expressing NKG2A

Медицинская иммунология
During infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon ...
N. A. Alekseeva, Yu. D. Vavilova, E. I. Kovalenko   +2 more
doaj   +1 more source

Torque teno viruses exhaust and imprint the human immune system via the HLA-E/NKG2A axis

Frontiers in Immunology
The ubiquitous Torque teno virus (TTV) establishes a chronically persistent infection in the human host. TTV has not been associated with any apparent disease, but, as part of the human virome, it may confer a regulatory imprint on the human immune ...
Hannes Vietzen, Cara Simonitsch, Benjamin Friedel, Sarah M. Berger, Laura M. Kühner, Philippe L. Furlano, David M. Florian, Irene Görzer, Maximilian Koblischke, Judith H. Aberle, Elisabeth Puchhammer-Stöckl   +10 more
doaj   +1 more source