Results 51 to 60 of about 9,856 (174)

High‐Dimensional Immune Profiling Identifies Circulating NKT‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset

Immunology, Volume 178, Issue 4, Page 685-703, August 2026.
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
Carolina González de Castro, Mª. Lourdes Ruiz Rebollo, Paloma Cal‐Sabater, Elisa Arribas‐Rodríguez, Álvaro Martín‐Muñoz, Alejandro Gonzalez del Hierro, Marina Perez Mazzali, Jessica Matesanz‐Isabel, Hugo Gonzalo‐Benito, Sara Cuesta‐Sancho, David Bernardo   +10 more
wiley   +1 more source

Inhibitory NKG2A+ and absent activating NKG2C+ NK cell responses are associated with the development of EBV+ lymphomas

Frontiers in Immunology, 2023
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, which infects over 90% of the adult human population worldwide. After primary infections, EBV is recurrently reactivating in most adult individuals.
Hannes Vietzen, Philipp B. Staber, Sarah M. Berger, Philippe L. Furlano, Laura M. Kühner, Simone Lubowitzki, Alexander Pichler, Robert Strassl, Jan J. Cornelissen, Elisabeth Puchhammer-Stöckl   +9 more
doaj   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Emerging Immune‐Based Therapeutic Strategies in Hepatocellular Carcinoma

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide despite recent advances in systemic therapy. The introduction of immune checkpoint inhibitors has substantially expanded treatment options for advanced disease; however, durable responses are observed only in a subset of patients.
Janine Kah, Werner Dammermann, Stefan Lueth   +2 more
wiley   +1 more source

High IL‐10 levels during CRS are negatively associated with NK‐cell recovery after CAR‐T cell therapy

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
This study demonstrates that high IL‐10 levels during cytokine release syndrome significantly delay natural killer (NK)‐cell recovery after CD19 CAR‐T cell therapy, increasing viral infection risks. Mechanistically, IL‐10 impairs NK‐cell recovery by promoting apoptosis and ferroptosis, suggesting that targeting IL‐10 or employing anti‐inflammatory ...
Xindi Wang, Wenjing Luo, Yingying Li, Jianghua Wu, Lu Tang, Chenggong Li, Qiaolin Liu, Zhihan Chen, Yu Hu, Heng Mei   +9 more
wiley   +1 more source

Mature T‐cell leukemia/lymphoma with an NK‐like immunophenotype: A report of 7 cases

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 4, Page 288-296, July 2026.
Abstract Distinguishing T‐cell from NK‐cell neoplasms can occasionally be challenging, as neoplastic T cells can lose T‐cell markers such as surface CD3 (sCD3) and CD5 while acquiring NK‐cell markers such as CD16, CD56, and CD94. In this study, we present a series of 7 mature T‐cell lymphoma/leukemia cases with NK‐like immunophenotypes to clarify ...
Wei J. Wang, Sa A. Wang, Hong Fang, Jeffrey L. Jorgensen, Shimin Hu, Lianqun Qiu, Jie Xu, L. Jeffrey Medeiros, Wei Wang   +8 more
wiley   +1 more source

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.

PLoS Pathogens, 2016
Major histocompatibility class I (MHC-I)-specific inhibitory receptors on natural killer (NK) cells (iNKRs) tolerize mature NK cell responses toward normal cells.
Zachary B Davis, Andrew Cogswell, Hamish Scott, Amanda Mertsching, Julie Boucau, Daniel Wambua, Sylvie Le Gall, Vicente Planelles, Kerry S Campbell, Edward Barker   +9 more
doaj   +1 more source

Downregulation of CD94/NKG2A inhibitory receptors on CD8⁺ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts

Retrovirology, 2007
The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8+ T lymphocytes.
Vaira Dolores, Schaaf-Lafontaine Nicole, Leonard Philippe, Frippiat Frédéric, Jacobs Nathalie, Vandamme Arnaud, Rahmouni Souad, Zeddou Mustapha, Boniver Jacques, Moutschen Michel   +9 more
doaj   +1 more source

The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims In the innate immune response, natural Killer (NK) cells have a significant role in protection against viral infections, including the Dengue virus (DENV). NK cells identify and eliminate virus‐infected cells through diverse mechanisms, such as cytokine production, cytolytic activity, and antibody‐dependent cellular ...
Farjana Islam
wiley   +1 more source

Frequency and role of NKp46 and NKG2A in hepatitis B virus infection

PLOS ONE, 2017
Natural Killer (NK) cells are involved in the control of viral infection. However, the role of NK cells in chronic hepatitis B (CHB) remains unclear. This study investigated the frequencies and roles of NK cells in CHB, with a focus on activating receptor NKp46 and inhibitory receptor NKG2A.Peripheral blood lymphocytes were obtained from 71 CHB ...
Teppei Yoshioka, Tomohide Tatsumi, Takuya Miyagi, Kaori Mukai, Kumiko Nishio, Akira Nishio, Yoshinobu Yokoyama, Takahiro Suda, Tadashi Kegasawa, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Tetsuo Takehara   +12 more
openaire   +4 more sources