Results 51 to 60 of about 15,525 (208)

NKG2A Down-Regulation by Dasatinib Enhances Natural Killer Cytotoxicity and Accelerates Effective Treatment Responses in Patients With Chronic Myeloid Leukemia

Frontiers in Immunology, 2019
Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of t(9;22) chromosomal translocation that results in BCR-ABL fusion gene.
Ming-Chin Chang, Ming-Chin Chang, Hung-I Cheng, Kate Hsu, Yen-Ning Hsu, Chen-Wei Kao, Yi-Fang Chang, Yi-Fang Chang, Yi-Fang Chang, Ken-Hong Lim, Ken-Hong Lim, Ken-Hong Lim, Caleb Gonshen Chen, Caleb Gonshen Chen, Caleb Gonshen Chen   +14 more
doaj   +1 more source

Generation and Regulation of CD8+ Regulatory T Cells [PDF]

, 2014
Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been given to the potential contribution
Cantor, Harvey, Lu, Linrong
core   +1 more source

Hepatic alveolar echinococcosis infection induces a decrease in NK cell function through high expression of NKG2A in patients

Frontiers in Immunology
Echinococcus multilocularis larval tapeworm infection in humans is considered a serious public health issue. The immune interaction between parasites and their hosts is extremely important. NK cells are known innate immune cells that play important roles
Abuduaini Abulizi, Abuduaini Abulizi, Talaiti Tuergan, Talaiti Tuergan, Paizula Shalayiadang, Paizula Shalayiadang, Chuanshan Zhang, Chuanshan Zhang, Ruiqing Zhang, Ruiqing Zhang, Tiemin Jiang, Tiemin Jiang, Qiang Guo, Qiang Guo, Hui Wang, Hui Wang, Liang Li, Liang Li, Renyong Lin, Renyong Lin, Yingmei Shao, Yingmei Shao, Tuerganaili Aji, Tuerganaili Aji   +23 more
doaj   +1 more source

Influence of tumors on protective anti-tumor immunity and the effects of irradiation [PDF]

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan Graham Pockley, Gabriele eMulthoff, Gabriele eMulthoff, Gemma Ann Foulds, Gemma Ann Foulds, Jürgen eRadons, Mira eKreuzer   +6 more
core   +2 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Natural killer NKG2A and NKG2D in patients with colorectal cancer

Journal of Gastrointestinal Oncology, 2019
Natural-killer group 2 (NKG2), a characteristic receptor of natural killer (NK) cell family, assumes a vital role in modulating NK cytotoxic function. We aimed to detect mRNA expression of both NKG2A and NKG2D in serum NK cells obtained from colorectal cancer (CRC) patients.We enrolled 36 patients with newly diagnosed CRC, as well as 15 group matched ...
Ghada R, Meckawy, Ahmed M, Mohamed, Wafaa K, Zaki, Mona A, Khattab, Mariam M, Amin, Mai A, ElDeeb, Marwa R, El-Najjar, Nesma A, Safwat   +7 more
openaire   +2 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

CD155 on HIV-infected cells is not modulated by HIV-1 Vpu and Nef but synergizes with NKG2D ligands to trigger NK cell lysis of autologous primary HIV-infected cells [PDF]

, 2017
Activation of primary CD4(+) T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)].
Barker, Edward, Cogswell, Andrew, Davis, Zacharay B, Plannelles, Vincente, Sowriajan, Bharatwaj, Ward, Jeffrey P   +5 more
core   +2 more sources

Predictive value of NKG2A+ NK cell population in diagnosing severe COVID-19 patients

Immunobiology
Objectives: To evaluate the predictive value of NKG2A+ natural killer (NK) cells in identifying patients at risk of developing severe COVID-19 and assess the therapeutic potential of NKG2A blockade in restoring NK cell antiviral activity.
Chunqiu Yang, Rui Qian, Mengtao Gong, Yizu Qin, Meijuan Zheng   +4 more
doaj   +1 more source

The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

Cell Reports, 2023
Summary: The immune checkpoint NKG2A/CD94 is a promising target for cancer immunotherapy, and its ligand major histocompatibility complex E (MHC-E) is frequently upregulated in cancer. NKG2A/CD94-mediated inhibition of lymphocytes depends on the presence
Jim Middelburg, Soroush Ghaffari, Tom A.W. Schoufour, Marjolein Sluijter, Gaby Schaap, Büsra Göynük, Benedetta M. Sala, Lejla Al-Tamimi, Ferenc Scheeren, Kees L.M.C. Franken, Jimmy J.L.L. Akkermans, Birol Cabukusta, Simone A. Joosten, Ian Derksen, Jacques Neefjes, Sjoerd H. van der Burg, Adnane Achour, Ruud H.M. Wijdeven, Jon Weidanz, Thorbald van Hall   +19 more
doaj   +1 more source