Results 31 to 40 of about 10,258 (173)

NKG2A and CD56 Are Coexpressed on Activated TH2 but Not TH1 Lymphocytes [PDF]

Human Immunology, 2005
NKG2A is commonly expressed on cytotoxic cells but has been found on activated T helper (TH) cells. In identifying novel markers differentiating between TH1 and TH2 lymphocytes, we focused on NKG2A expression. TH1 and TH2 cells were negatively isolated from healthy volunteers for microarray analysis and reverse transcription polymerase chain reaction ...
Robert J, Freishtat, Lindsay W, Mitchell, Svetlana D, Ghimbovschi, Samuel B, Meyers, Eric P, Hoffman   +4 more
openaire   +2 more sources

NKG2A Inhibits Invariant NKT Cell Activation in Hepatic Injury [PDF]

The Journal of Immunology, 2009
Abstract Activation of invariant NKT (iNKT) cells in the liver is generally regarded as the critical step for Con A-induced hepatitis, and the role of NK cell receptors for iNKT cell activation is still controversial. In this study we show that blockade of the NKG2A-mediated inhibitory signal with antagonistic anti-NKG2A/C/E mAb (20d5)
Kawamura, Toshihiko, Takeda, Kazuyoshi, Kaneda, Hiroshi, Matsumoto, Hiroaki, Hayakawa, Yoshihiro, Raulet, David H., Ikarashi, Yoshinori, Kronenberg, Mitchell, Yagita, Hideo, Kinoshita, Katsuyuki, Abo, Toru, Okumura, Ko, Smyth, Mark J.   +12 more
openaire   +4 more sources

Increased NKG2A+CD8+ T-cell exhaustion in patients with adenomyosis

Mucosal Immunology, 2023
Immune dysregulation has long been proposed to be associated with adenomyosis, but the underlying mediators and mechanisms remain largely unexplored. Here, we used flow cytometry to investigate the alterations in immune cell subsets in adenomyotic uteri and analyze the phenotype and function of abnormal immune cells.
Wei, Liu, Shuman, Sheng, Chendi, Zhu, Changzhong, Li, Yonghui, Zou, Chunrun, Yang, Zi-Jiang, Chen, Fei, Wang, Xue, Jiao   +8 more
openaire   +2 more sources

NKG2A Down-Regulation by Dasatinib Enhances Natural Killer Cytotoxicity and Accelerates Effective Treatment Responses in Patients With Chronic Myeloid Leukemia

Frontiers in Immunology, 2019
Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of t(9;22) chromosomal translocation that results in BCR-ABL fusion gene.
Ming-Chin Chang, Ming-Chin Chang, Hung-I Cheng, Kate Hsu, Yen-Ning Hsu, Chen-Wei Kao, Yi-Fang Chang, Yi-Fang Chang, Yi-Fang Chang, Ken-Hong Lim, Ken-Hong Lim, Ken-Hong Lim, Caleb Gonshen Chen, Caleb Gonshen Chen, Caleb Gonshen Chen   +14 more
doaj   +1 more source

Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection. [PDF]

PLoS ONE, 2014
Virus infection triggers a CD8(+) T cell response that aids in virus clearance, but also expresses effector functions that may result in tissue injury.
Kenneth H Ely, Mitsuo Matsuoka, Matthew P DeBerge, Jessica A Ruby, Jun Liu, Mark J Schneider, Yan Wang, Young S Hahn, Richard I Enelow   +8 more
doaj   +1 more source

Association of NKG2A with treatment for chronic hepatitis C virus infection [PDF]

Clinical and Experimental Immunology, 2010
SummaryNatural killer (NK) cells are critical to the immune response to viral infections. Their functions are controlled by receptors for major histocompatibility complex (MHC) class I, including NKG2A and killer-cell immunoglobulin-like receptors (KIR).
Harrison, R.J., Ettorre, A., Little, A-M., Khakoo, S.I.   +3 more
openaire   +3 more sources

Hepatic alveolar echinococcosis infection induces a decrease in NK cell function through high expression of NKG2A in patients

Frontiers in Immunology
Echinococcus multilocularis larval tapeworm infection in humans is considered a serious public health issue. The immune interaction between parasites and their hosts is extremely important. NK cells are known innate immune cells that play important roles
Abuduaini Abulizi, Abuduaini Abulizi, Talaiti Tuergan, Talaiti Tuergan, Paizula Shalayiadang, Paizula Shalayiadang, Chuanshan Zhang, Chuanshan Zhang, Ruiqing Zhang, Ruiqing Zhang, Tiemin Jiang, Tiemin Jiang, Qiang Guo, Qiang Guo, Hui Wang, Hui Wang, Liang Li, Liang Li, Renyong Lin, Renyong Lin, Yingmei Shao, Yingmei Shao, Tuerganaili Aji, Tuerganaili Aji   +23 more
doaj   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

TCR Specificity Dictates CD94/NKG2A Expression by Human CTL [PDF]

Immunity, 2002
Activating and inhibitory CD94/NKG2 receptors regulate CTL responses by altering TCR signaling, thus modifying antigen activation thresholds set during thymic selection. To determine whether their expression was linked to TCR specificity, we examined the TCR repertoire of oligoclonal CTL expansions found in human blood and tissues.
Jabri, Bana, Selby, Jeanette M, Negulescu, Horia, Lee, Leanne, Roberts, Arthur I, Beavis, Andrew, Lopez-Botet, Miguel, Ebert, Ellen C, Winchester, Robert J   +8 more
openaire   +2 more sources