Results 31 to 40 of about 9,856 (174)

Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection. [PDF]

PLoS ONE, 2014
Virus infection triggers a CD8(+) T cell response that aids in virus clearance, but also expresses effector functions that may result in tissue injury.
Kenneth H Ely, Mitsuo Matsuoka, Matthew P DeBerge, Jessica A Ruby, Jun Liu, Mark J Schneider, Yan Wang, Young S Hahn, Richard I Enelow   +8 more
doaj   +1 more source

Association of NKG2A with treatment for chronic hepatitis C virus infection [PDF]

Clinical and Experimental Immunology, 2010
SummaryNatural killer (NK) cells are critical to the immune response to viral infections. Their functions are controlled by receptors for major histocompatibility complex (MHC) class I, including NKG2A and killer-cell immunoglobulin-like receptors (KIR).
Harrison, R.J., Ettorre, A., Little, A-M., Khakoo, S.I.   +3 more
openaire   +3 more sources

NKG2A Down-Regulation by Dasatinib Enhances Natural Killer Cytotoxicity and Accelerates Effective Treatment Responses in Patients With Chronic Myeloid Leukemia

Frontiers in Immunology, 2019
Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of t(9;22) chromosomal translocation that results in BCR-ABL fusion gene.
Ming-Chin Chang, Ming-Chin Chang, Hung-I Cheng, Kate Hsu, Yen-Ning Hsu, Chen-Wei Kao, Yi-Fang Chang, Yi-Fang Chang, Yi-Fang Chang, Ken-Hong Lim, Ken-Hong Lim, Ken-Hong Lim, Caleb Gonshen Chen, Caleb Gonshen Chen, Caleb Gonshen Chen   +14 more
doaj   +1 more source

Hepatic alveolar echinococcosis infection induces a decrease in NK cell function through high expression of NKG2A in patients

Frontiers in Immunology
Echinococcus multilocularis larval tapeworm infection in humans is considered a serious public health issue. The immune interaction between parasites and their hosts is extremely important. NK cells are known innate immune cells that play important roles
Abuduaini Abulizi, Abuduaini Abulizi, Talaiti Tuergan, Talaiti Tuergan, Paizula Shalayiadang, Paizula Shalayiadang, Chuanshan Zhang, Chuanshan Zhang, Ruiqing Zhang, Ruiqing Zhang, Tiemin Jiang, Tiemin Jiang, Qiang Guo, Qiang Guo, Hui Wang, Hui Wang, Liang Li, Liang Li, Renyong Lin, Renyong Lin, Yingmei Shao, Yingmei Shao, Tuerganaili Aji, Tuerganaili Aji   +23 more
doaj   +1 more source

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Predictive value of NKG2A+ NK cell population in diagnosing severe COVID-19 patients

Immunobiology
Objectives: To evaluate the predictive value of NKG2A+ natural killer (NK) cells in identifying patients at risk of developing severe COVID-19 and assess the therapeutic potential of NKG2A blockade in restoring NK cell antiviral activity.
Chunqiu Yang, Rui Qian, Mengtao Gong, Yizu Qin, Meijuan Zheng   +4 more
doaj   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

TCR Specificity Dictates CD94/NKG2A Expression by Human CTL [PDF]

Immunity, 2002
Activating and inhibitory CD94/NKG2 receptors regulate CTL responses by altering TCR signaling, thus modifying antigen activation thresholds set during thymic selection. To determine whether their expression was linked to TCR specificity, we examined the TCR repertoire of oligoclonal CTL expansions found in human blood and tissues.
Jabri, Bana, Selby, Jeanette M, Negulescu, Horia, Lee, Leanne, Roberts, Arthur I, Beavis, Andrew, Lopez-Botet, Miguel, Ebert, Ellen C, Winchester, Robert J   +8 more
openaire   +2 more sources

The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

Cell Reports, 2023
Summary: The immune checkpoint NKG2A/CD94 is a promising target for cancer immunotherapy, and its ligand major histocompatibility complex E (MHC-E) is frequently upregulated in cancer. NKG2A/CD94-mediated inhibition of lymphocytes depends on the presence
Jim Middelburg, Soroush Ghaffari, Tom A.W. Schoufour, Marjolein Sluijter, Gaby Schaap, Büsra Göynük, Benedetta M. Sala, Lejla Al-Tamimi, Ferenc Scheeren, Kees L.M.C. Franken, Jimmy J.L.L. Akkermans, Birol Cabukusta, Simone A. Joosten, Ian Derksen, Jacques Neefjes, Sjoerd H. van der Burg, Adnane Achour, Ruud H.M. Wijdeven, Jon Weidanz, Thorbald van Hall   +19 more
doaj   +1 more source