Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
Nature Communications, 2019 Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell ...
Branca I. Pereira +15 more
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Frontiers in Veterinary ScienceAlpacas belong to the Camelidae family. Antibodies produced through alpaca immunization are called nanoantibodies. Compared to traditional antibodies, nanoantibodies have several characteristics, including smaller molecular weight, stable structure, high
Xiang Guo +10 more
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Increased proliferative response of highly differentiated CD57+NKG2C+NK cells expressing NKG2A
Медицинская иммунологияDuring infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon ...
N. A. Alekseeva +2 more
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Torque teno viruses exhaust and imprint the human immune system via the HLA-E/NKG2A axis
Frontiers in ImmunologyThe ubiquitous Torque teno virus (TTV) establishes a chronically persistent infection in the human host. TTV has not been associated with any apparent disease, but, as part of the human virome, it may confer a regulatory imprint on the human immune ...
Hannes Vietzen +10 more
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Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
Nature Communications, 2019 MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking.
Xiaoqian Zhang +4 more
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HIV viraemic patients downregulate CD94/NKG2A inhibitory receptors on NK as well as CD8 T cells in comparison with aviraemic counterparts [PDF]
, 2006 Background: The CD94/NKG2 heterodimer is a C-type lectin receptor formed by the association of CD94 and one of the NKG2 molecules (namely NKG2A, -B, -C or –E).
Moutschen, Michel +4 more
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Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement [PDF]
, 2017 Key, Phillip N +5 more
core +2 more sources
Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor
MedHuman leukocyte antigen (HLA)-E is overexpressed by a large proportion of solid tumors, including malignant glioblastoma, and acts as a major checkpoint for NKG2A+ CD8+ T cells and natural killer (NK) cells in the tumor microenvironment and circulation.
Michelle Sætersmoen +8 more
openaire +2 more sources
Az implantáció immunológiája: Az anyai immunrendszer szabályozási mechanizmusainak vizsgálata a beágyazódás során = The role of maternal immune system during implantation [PDF]
, 2009 Az NK, iNKT sejtek és gamma/delta T sejtek szerepet játszanak a elégtelen implantáció következtében kialakuló kóros terhesség állapotok, mint pl. a pre-eclampsia kialakulásában.
Szereday, László
core
AntibodiesImmuno-oncology has revolutionized cancer treatment, with NKG2A emerging as a novel target for immunotherapy. The blockade of NKG2A using the immune checkpoint inhibitor (ICI) monalizumab has been shown to enhance the responses of both NK cells and CD8 ...
Yaqiong Zhou +13 more
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