Results 101 to 110 of about 15,525 (208)

A Novel Prognostic Nomogram Based on TIGIT and NKG2A Can Predict Relapse‐Free Survival of Hepatocellular Carcinoma After Hepatectomy

Cancer Medicine
Background and Objectives Hepatocellular carcinoma (HCC) is a major global health concern, and emerging evidence suggests that TIGIT and NKG2A are potential immune checkpoints with implications for HCC progression.
Junqi Wang, Yuqing Cao, Yu Tian, Chaoliu Dai, Tianqiang Jin, Feng Xu   +5 more
doaj   +1 more source

A role for DNA hypomethylation and histone acetylation in maintaining allele-specific expression of mouse NKG2A in developing and mature NK cells. [PDF]

, 2006
The repertoire of receptors that is expressed by NK cells is critical for their ability to kill virally infected or transformed cells. However, the molecular mechanisms that determine whether and when NK receptor genes are transcribed during hemopoiesis ...
Mager, Dixie L, Rogers, Sally L, Rouhi, Arefeh, Takei, Fumio   +3 more
core   +1 more source

NKG2A and COVID-19: another brick in the wall [PDF]

Cellular & Molecular Immunology, 2020
Antonioli L., Fornai M., Pellegrini C., Blandizzi C.   +3 more
openaire   +3 more sources

Natural killer cells in herpesvirus infections [PDF]

, 2017
Natural killer (NK) cells are potent innate cytotoxic lymphocytes for the destruction of infected and transformed cells. Although they were originally considered to be ready-made assassins after their hematopoietic development, it has recently become ...
Chijioke, Obinna, Münz, Christian
core   +1 more source

Unlocking the therapeutic potential of the NKG2A-HLA-E immune checkpoint pathway in T cells and NK cells for cancer immunotherapy

Journal for ImmunoTherapy of Cancer
Immune checkpoint blockade, which enhances the reactivity of T cells to eliminate cancer cells, has emerged as a potent strategy in cancer therapy. Besides T cells, natural killer (NK) cells also play an indispensable role in tumor surveillance and ...
Yan Li, Patrick P C Boor, Dave Sprengers, Zhu Li, Sonja Buschow, Yisen Tang, Xiaomei Zhuang, Wanhua Feng, Guoying Zhou   +8 more
doaj   +1 more source

Safety and Feasibility of Blockade of NK Group-2 Member-A Receptor in Natural Killer Cells Combined with Cetuximab Antibody in Patients with Advanced Gastric Adenocarcinoma [PDF]

Advanced Pharmaceutical Bulletin
Purpose: Blocking of inhibitory receptors such as NK group-2 member-A (NKG2A) enhances tumor immunity of natural killer (NK) cells. Additionally, antibody-dependent cellular cytotoxicity (ADCC) is an important cytotoxic modality of action of NK cells ...
Maryam Samareh-Salavatipour, Shirin Tavakoli, Maryam Barkhordar, Iman Seyhoun, Nasim Vousooghi, Mohammad Vaezi, Afshin Ghaderi, Tahereh Bakhtiari, Ardeshir Ghavamzadeh, Javad Verdi, Mohammad Ahmadvand   +10 more
doaj   +1 more source

Anàlisis dels immunofenotips dels NKR de les cèl·lules Natural Killer en pacients amb Esclerosi Múltiple (MS). [PDF]

, 2014
Curs 2013-2014La MS és una malaltia autoimmunitària les causes de la qual són encara desconegudes. Entre altres efectes, els pacients d’aquesta malaltia veuen reduït el nombre de limfòcits, així com el percentatge d’aquests ocupats pel compartiment NK ...
Pintó Juncà, Meritxell
core  

Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.

PLoS ONE, 2011
ObjectiveTNF inhibitors (TNFi) have revolutionised the treatment of rheumatoid arthritis (RA). Natural killer (NK) cells and Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose activity is tightly regulated through ...
Ceara E Walsh, Elizabeth J Ryan, Cliona O'Farrelly, Lucy Golden-Mason, Lucy Golden-Mason, Oliver FitzGerald, Douglas J Veale, Barry Bresnihan, Ursula Fearon   +8 more
doaj   +1 more source

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence. [PDF]

, 2020
There is a growing body of literature demonstrating the importance of T cell exhaustion in regulating and shaping immune responses to pathogens and cancer.
Canter, Robert J, Judge, Sean J, Murphy, William J   +2 more
core  

Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis

Clinical & Translational Immunology
Objectives Immunotherapies targeting natural killer (NK) cell receptors have shown promise against leukaemia. Unfortunately, cancer immunosuppressive mechanisms that alter NK cell phenotype prevent such approaches from being successful.
Cui Tu, Irina Buckle, Ingrid Leal Rojas, Gustavo Rodrigues Rossi, David P Sester, Andrew S Moore, Kristen Radford, Camille Guillerey, Fernando Souza‐Fonseca‐Guimaraes   +8 more
doaj   +1 more source