Results 31 to 40 of about 4,280 (166)

Impact of an Immune Modulator Mycobacterium-w on Adaptive Natural Killer Cells and Protection Against COVID-19

Frontiers in Immunology, 2022
The kinetics of NKG2C+ adaptive natural killer (ANK) cells and NKG2A+inhibitory NK (iNK) cells with respect to the incidence of SARS-CoV-2 infection were studied for 6 months in a cohort of healthcare workers following the administration of the heat ...
Sarita Rani Jaiswal, Sarita Rani Jaiswal, Sarita Rani Jaiswal, Jaganath Arunachalam, Ashraf Saifullah, Rohit Lakhchaura, Dhanir Tailor, Anupama Mehta, Gitali Bhagawati, Hemamalini Aiyer, Bakulesh Khamar, Sanjay V. Malhotra, Suparno Chakrabarti, Suparno Chakrabarti   +13 more
doaj   +1 more source

Cytotoxic NKG2C+ CD4 T Cells Target Oligodendrocytes in Multiple Sclerosis [PDF]

The Journal of Immunology, 2013
Abstract The mechanisms whereby immune cells infiltrating the CNS in multiple sclerosis patients contribute to tissue injury remain to be defined. CD4 T cells are key players of this inflammatory response. Myelin-specific CD4 T cells expressing CD56, a surrogate marker of NK cells, were shown to be cytotoxic to human oligodendrocytes ...
Fatma, Zaguia, Philippe, Saikali, Samuel, Ludwin, Jia, Newcombe, Diane, Beauseigle, Ellie, McCrea, Pierre, Duquette, Alexandre, Prat, Jack P, Antel, Nathalie, Arbour   +9 more
openaire   +2 more sources

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Cell Reports, 2016
Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C ...
Lisa L. Liu, Johannes Landskron, Eivind H. Ask, Monika Enqvist, Ebba Sohlberg, James A. Traherne, Quirin Hammer, Jodie P. Goodridge, Stella Larsson, Jyothi Jayaraman, Vincent Y.S. Oei, Marie Schaffer, Kjetil Taskén, Hans-Gustaf Ljunggren, Chiara Romagnani, John Trowsdale, Karl-Johan Malmberg, Vivien Béziat   +17 more
doaj   +1 more source

Which NK cell populations mark the high burden of CMV present in all HIV patients beginning ART in Indonesia?

AIDS Research and Therapy, 2022
Background Cytomegalovirus (CMV) has been linked with cardiovascular disease (CVD) in populations where some individuals are seronegative. However, effects of CMV are unclear in HIV patients who all have high levels of CMV antibodies.
Ibnu A. Ariyanto, Riwanti Estiasari, Birry Karim, Ika Praseya Wijaya, Budiman Bela, Amin Soebandrio, Patricia Price, Silvia Lee   +7 more
doaj   +1 more source

Inhibitory NKG2A+ and absent activating NKG2C+ NK cell responses are associated with the development of EBV+ lymphomas

Frontiers in Immunology, 2023
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, which infects over 90% of the adult human population worldwide. After primary infections, EBV is recurrently reactivating in most adult individuals.
Hannes Vietzen, Philipp B. Staber, Sarah M. Berger, Philippe L. Furlano, Laura M. Kühner, Simone Lubowitzki, Alexander Pichler, Robert Strassl, Jan J. Cornelissen, Elisabeth Puchhammer-Stöckl   +9 more
doaj   +1 more source

Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System

Frontiers in Immunology, 2017
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with additional distinctive phenotypic and
Aldi Pupuleku, Marcel Costa-García, Domènec Farré, Hartmut Hengel, Hartmut Hengel, Ana Angulo, Ana Angulo, Aura Muntasell, Miguel López-Botet, Miguel López-Botet   +9 more
doaj   +1 more source

High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

Nature Communications, 2023
HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown HLA-E can present diverse peptides to NK cells and T cells, the HLA-E repertoire recognized by CD94/NKG2x has remained poorly
Brooke D. Huisman, Ning Guan, Timo Rückert, Lee Garner, Nishant K. Singh, Andrew J. McMichael, Geraldine M. Gillespie, Chiara Romagnani, Michael E. Birnbaum   +8 more
doaj   +1 more source

NKG2C, HLA‐E and their association with psoriasis [PDF]

Experimental Dermatology, 2013
AbstractNatural killer (NK) cell activation is regulated by the integration of signals from inhibitory and activating cell surface receptors. Both NKG2A and NKG2C pair with CD94 to form inhibitory and activating receptors specific for the HLA‐E‐canonical peptide complex. HLA‐E is a non‐classical MHC class Ib molecule with limited polymorphism.
Patel, Forum, Marusina, Alina I, Duong, Christopher, Adamopoulos, Iannis E, Maverakis, Emanual   +4 more
openaire   +4 more sources

Cytomegalovirus-Driven Adaption of Natural Killer Cells in NKG2Cnull Human Immunodeficiency Virus-Infected Individuals

Viruses, 2019
Expansion of natural killer (NK) cells expressing NKG2C occurs following human cytomegalovirus (HCMV) infection and is amplified by human immunodeficiency virus (HIV) co-infection.
Emilie M. Comeau, Kayla A. Holder, Neva J. Fudge, Michael D. Grant   +3 more
doaj   +1 more source

NK Cells Acquire CCR5 and CXCR4 by Trogocytosis in People Living with HIV-1

Vaccines, 2022
NK cells play a major role in the antiviral immune response, including against HIV-1. HIV-1 patients have impaired NK cell activity with a decrease in CD56dim NK cells and an increase in the CD56−CD16+ subset, and recently it has been proposed that a ...
Dang-Nghiem Vo, Nicolas Leventoux, Mauricio Campos-Mora, Sandrine Gimenez, Pierre Corbeau, Martin Villalba   +5 more
doaj   +1 more source