Results 31 to 40 of about 5,274 (162)

Which NK cell populations mark the high burden of CMV present in all HIV patients beginning ART in Indonesia?

open access: yesAIDS Research and Therapy, 2022
Background Cytomegalovirus (CMV) has been linked with cardiovascular disease (CVD) in populations where some individuals are seronegative. However, effects of CMV are unclear in HIV patients who all have high levels of CMV antibodies.
Ibnu A. Ariyanto   +7 more
doaj   +1 more source

Inhibitory NKG2A+ and absent activating NKG2C+ NK cell responses are associated with the development of EBV+ lymphomas

open access: yesFrontiers in Immunology, 2023
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, which infects over 90% of the adult human population worldwide. After primary infections, EBV is recurrently reactivating in most adult individuals.
Hannes Vietzen   +9 more
doaj   +1 more source

Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System

open access: yesFrontiers in Immunology, 2017
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with additional distinctive phenotypic and
Aldi Pupuleku   +9 more
doaj   +1 more source

High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

open access: yesNature Communications, 2023
HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown HLA-E can present diverse peptides to NK cells and T cells, the HLA-E repertoire recognized by CD94/NKG2x has remained poorly
Brooke D. Huisman   +8 more
doaj   +1 more source

Cytomegalovirus-Driven Adaption of Natural Killer Cells in NKG2Cnull Human Immunodeficiency Virus-Infected Individuals

open access: yesViruses, 2019
Expansion of natural killer (NK) cells expressing NKG2C occurs following human cytomegalovirus (HCMV) infection and is amplified by human immunodeficiency virus (HIV) co-infection.
Emilie M. Comeau   +3 more
doaj   +1 more source

NK Cells Acquire CCR5 and CXCR4 by Trogocytosis in People Living with HIV-1

open access: yesVaccines, 2022
NK cells play a major role in the antiviral immune response, including against HIV-1. HIV-1 patients have impaired NK cell activity with a decrease in CD56dim NK cells and an increase in the CD56−CD16+ subset, and recently it has been proposed that a ...
Dang-Nghiem Vo   +5 more
doaj   +1 more source

CG simulation of DAP12-NKG2C-DAP12 trimer with an additional NKG2C receptor.

open access: yes, 2014
A. The evolution of minimum distance between side chain beads of Asp and Lys. B. Spatial distribution of the DAP12 dimer in the reference frame of NKG2C-1 (upper panel) and NKG2C-2 (lower panel). C.
Cheng-Dong Li (620106)   +6 more
core   +1 more source

Theoretical Elucidation of the Origin for Assembly of the DAP12 Dimer with Only One NKG2C in the Lipid Membrane

open access: yes, 2013
in this work, we have investigated in details the origin of the assembly of the DAP12 dimer with only one NKG2C in the activating immunoreceptor complex from thew two aspects of electronic properties and dynamic structures by performing density ...
Shen, Hujun   +5 more
core   +1 more source

Association of DAP12 with Activating CD94/NKG2C NK Cell Receptors [PDF]

open access: yes, 1998
While the inhibitory NK cell receptors for MHC class I express immunoreceptor tyrosine-based inhibitory motifs that recruit intracellular tyrosine phosphatases and prevent NK cell effector function, the activating NK cell receptors lack intrinsic ...
Wu, Jun   +3 more
core   +1 more source

Increased early activation of CD56dimCD16dim/- natural killer cells in immunological non-responders correlates with CD4+ T-cell recovery

open access: yesChinese Medical Journal, 2020
. Background. Natural killer (NK) cells play a critical role in suppressing human immunodeficiency virus-1 (HIV-1) infection, but knowledge on whether and how NK cells affect immune reconstitution in HIV-1-infected individuals who receive antiretroviral ...
Qiu-Yue Zhang   +10 more
doaj   +1 more source

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