Results 141 to 150 of about 46,134 (291)

Impact of Human Cytomegalovirus Infection and its Immune Response on Survival of Patients with Ovarian Cancer

Translational Oncology, 2018
Human cytomegalovirus (HCMV) has been detected in various types of tumors. We studied the prevalence of HCMV in ovarian cancer and its relation to clinical outcome. Paraffin-embedded tissues obtained prospectively from 45 patients with ovarian cancer and
Angelique Flöter Rådestad, Atosa Estekizadeh, Huanhuan L Cui, Ourania N. Kostopoulou, Belghis Davoudi, Angelica Lindén Hirschberg, Joseph Carlson, Afsar Rahbar, Cecilia Söderberg-Naucler   +8 more
doaj   +1 more source

Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins [PDF]

, 1990
The regulation of murine cytomegalovirus early (E) gene expression was studied in the cell line B25, which is stably transfected with the immediate-early ie1/ie3 gene complex.
Bühler, Bernhard, Keil, Günther M., Koszinowski, Ulrich H., Weiland, Frank   +3 more
core   +1 more source

Characterization of the murine cytomegalovirus genes encoding the major DNA binding protein and the ICP18.5 homolog [PDF]

, 1992
In several herpesviruses the genes for the major DNA binding protein (MDBP), a putative assembly protein, the glycoprotein B (gB), and the viral DNA polymerase (pol) coliocate.
Keil, Günther M., Koszinowski, Ulrich H., Messerle, Martin, Schneider, Karin   +3 more
core   +1 more source

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody

Nature Communications, 2015
Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its ...
S. Chandramouli, C. Ciferri, P. Nikitin, Stefano Caló, Rachel Gerrein, Kara Balabanis, J. Monroe, C. Hebner, A. Lilja, E. Settembre, A. Carfi   +10 more
semanticscholar   +1 more source

Human Cytomegalovirus (HCMV) – Revised [PDF]

Transfusion Medicine and Hemotherapy, 2010
Schottstedt, Volkmar, Blümel, Johannes, Burger, Reinhard, Drosten, Christian, Gröner, Albrecht, Gürtler, Lutz G., Heiden, Margarethe, Hildebrandt, Martin, Jansen, Bernd, Montag-Lessing, Thomas, Offergeld, Ruth, Pauli, Georg, Seitz, Rainer, Schlenkrich, Uwe, Strobel, Johanna, Willkommen, Hannelore, Wirsing von König, Carl-Heinz   +16 more
openaire   +3 more sources

A Novel Link between Stress and Human Cytomegalovirus (HCMV) Infection: Sympathetic Hyperactivity Stimulates HCMV Activation

Virology, 2000
Recently, inflammatory mediators such as TNFalpha were identified as triggering active human cytomegalovirus (HCMV) infection. Here, we demonstrate that a highly stressful event in the absence of systemic inflammation, as observed in patients with acute myocardial infarction, leads to the development of an active HCMV infection in latently infected ...
Prösch, Susanna, Wendt, Cornelia E.C., Reinke, Petra, Priemer, Christina, Oppert, Michael, Krüger, Detlev H., Volk, Hans-Dieter, Döcke, Wolf-Dietrich   +7 more
openaire   +2 more sources

Serological Evidence and Sociodemographic Risk Factors of Recent Cytomegalovirus Infection in Pregnant Women Attending a Tertiary Hospital in Maiduguri, Nigeria

Journal of Medical Microbiology and Infectious Diseases, 2014
Introduction : Human cytomegalovirus (HCMV) is able to go into latency and is the most common cause of congenital infections in humans. Its clinical manifestations range from asymptomatic forms to severe fetal damage, and in rare cases, fetal death due ...
Adamu Babayo, Thairu Yunusa, Idris Abdullahi Nasir, Marycelin B. Baba   +3 more
doaj  

Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]

, 2013
Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
core   +1 more source

Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

PLoS Pathogens, 2015
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I
J. Hsu, D. J. van den Boomen, P. Tomasec, M. Weekes, R. Antrobus, R. Stanton, E. Růčková, D. Sugrue, G. Wilkie, A. Davison, G. Wilkinson, P. Lehner   +11 more
semanticscholar   +1 more source

Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation

Frontiers in Immunology
Human cytomegalovirus (HCMV) is the most common virus to affect the recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). HCMV reactivation increases the risk of secondary fungal and bacterial infections, as well as that of non ...
Yuanqi Zhao, Yuanqi Zhao, Yuanqi Zhao, Sisi Zhen, Sisi Zhen, Jiali Wang, Jiali Wang, Jieru Wang, Jieru Wang, Runzhi Ma, Runzhi Ma, Li Liu, Li Liu, Aiming Pang, Aiming Pang, Rongli Zhang, Rongli Zhang, Xin Chen, Xin Chen, Weihua Zhai, Weihua Zhai, Donglin Yang, Donglin Yang, Yi He, Yi He, Mingzhe Han, Mingzhe Han, Erlie Jiang, Erlie Jiang, Sizhou Feng, Sizhou Feng   +30 more
doaj   +1 more source