NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection
NKp30 is a crucial activating receptor on the surface of NK cells, mediating NK cell activation or the release of regulatory factors to exert cytotoxic effects by recognizing and binding to corresponding ligands. This article discusses the glycosylation of NKp30 and its pivotal role in antitumor and anti‐infection responses.
Yushu Shao+7 more
wiley +1 more source
The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions
Although human cytomegalovirus (HCMV) is generally not regarded to be an oncogenic virus, HCMV infection has been implicated in malignant diseases from different cancer entities.
Martin Michaelis+2 more
doaj +1 more source
A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus [PDF]
Using the simian virus 40 "enhancer trap" approach, we have identified a transcription enhancer located just upstream of the major immediate early gene of murine cytomegalovirus. This enhancer has several striking properties.
Dorsch-Häsler, Karoline+5 more
core +1 more source
Is the presence of HCMV components in CNS tumors a glioma-specific phenomenon?
Background Human cytomegalovirus (HCMV) has been associated with malignant gliomas. The purpose of the present study was to investigate the presence of HCMV in common non-glial tumors of the central nervous system (CNS) and to determine whether it is a ...
Daling Ding+5 more
doaj +1 more source
Modulation of Natural Killer Cell Cytotoxicity in Human Cytomegalovirus Infection: The Role of Endogenous Class I Major Histocompatibility Complex and a Viral Class I Homolog [PDF]
Natural killer (NK) cells have been implicated in early immune responses against certain viruses, including cytomegalovirus (CMV). CMV causes downregulation of class I major histocompatibility complex (MHC) expression in infected cells; however, it has ...
Bjorkman, Pamela J.+6 more
core +2 more sources
Synthesis of 5-substituted 2'-deoxyuridine-5'-phosphonate analogues and evaluation of their antiviral activity [PDF]
A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling.
Balzarini, Jan+4 more
core +1 more source
Human Cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and in fetuses following congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are required for HCMV entry in ...
C. Ciferri+12 more
semanticscholar +1 more source
MORC3, a component of PML nuclear bodies, has a role in restricting herpes simplex virus type 1 and human cytomegalovirus [PDF]
We previously reported that MORC3, a protein associated with promyelocytic leukemia nuclear bodies (PML NBs), is a target of HSV-1 ICP0 mediated degradation.
Everett, Roger+2 more
core +1 more source
Recently, inflammatory mediators such as TNFalpha were identified as triggering active human cytomegalovirus (HCMV) infection. Here, we demonstrate that a highly stressful event in the absence of systemic inflammation, as observed in patients with acute myocardial infarction, leads to the development of an active HCMV infection in latently infected ...
Hans-Dieter Volk+7 more
openaire +3 more sources
Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3. [PDF]
We have previously defined ie3 as a coding region located downstream of the ie1 gene which gives rise to a 2.75-kb immediate-early (IE) transcript. Here we describe the structural organization of the ie3 gene, the amino acid sequence of the gene product,
Bühler, Bernhard+3 more
core +1 more source