Results 71 to 80 of about 44,631 (298)

A model for HCMV infection in immunosuppressed patients

Mathematical and Computer Modelling, 2009
We propose a model for HCMV infection in healthy and immunosuppressed patients. First, we present the biological model and formulate a system of ordinary differential equations to describe the pathogenesis of primary HCMV infection in immunocompetent and immunosuppressed individuals.
Marie Davidian, Grace M. Kepler, Harvey Thomas Banks, Eric S. Rosenberg   +3 more
openaire   +3 more sources

Human Cytomegalovirus (HCMV)-infected Astrocytoma Cells Impair the Function of HCMV-specific Cytotoxic T Cells [PDF]

Journal of Korean Medical Science, 2020
Human cytomegalovirus (HCMV) infection in glioblastoma multiforme (GBM) is associated with a poor prognosis and may affect the pathogenesis of GBM. In this study, we investigated the role of HCMV-infected astrocytoma cells in impairing the activity of cytotoxic T lymphocytes (CTLs) specific to the HCMV protein.CTLs specific to HCMV immediate early (IE)-
Won Woo Lee, Won Woo Lee, Eung Soo Hwang, Eung Soo Hwang, Ji Yeon Kim, Ji Yeon Kim   +5 more
openaire   +3 more sources

Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan

Polish Journal of Microbiology, 2023
Human Cytomegalovirus (HCMV) is a leading healthcare problem associated with stillbirth and congenital abnormalities. Determining the seroprevalence and the possible risk factors related to HCMV infections may be a cornerstone in preventing its ...
Moglad Ehssan H., Hassan Ahmed O., Atta Elmanan Mawada S., Saeed Samar M., Abdalla Wafaa Mohammed, Mohammedsalih Kawthar Abdelgaleil, Ali Hatim T., Abd Elaziz Mohammed Siddig, Ahmed Hind Haidar   +8 more
doaj   +1 more source

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins [PDF]

, 2017
Using a high throughput screening methodology we surveyed a collection of largely uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) activity.
Beelontally, Rooksarr, Davison, Andrew J., Deng, Xianming, Goodmaker, Charles J., Gray, Nathanael S., Ho, Catherine M.K., Lau, Betty, Strang, Blair L., Swanson, Chad M., Wang, Jinhua, Wilkie, Gavin S.   +10 more
core   +2 more sources

Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

International Journal of Molecular Sciences, 2019
The outcome of host-virus interactions is determined by a number of factors, some related to the virus, others to the host, such as environmental factors and genetic factors.
A. Aiello, G. Accardi, G. Candore, C. Caruso, C. Colomba, D. Di Bona, G. Duro, C. Gambino, M. E. Ligotti, J. Pandey   +9 more
semanticscholar   +1 more source

Human cytomegalovirus: taking the strain [PDF]

, 2015
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently needed treatments.
Aicheler, Rebecca, Davison, Andrew J., Fielding, Ceri A., Lehner, Paul J., Murrell, Isa, Seirafian, Sepher, Stanton, Richard J., Tomasec, Peter, Wang, Edward C. Y., Weekes, Michael, Wilkie, Gavin, Wilkinson, Gavin W. G.   +11 more
core   +3 more sources

The Inhibition of miR-144-3p on Cell Proliferation and Metastasis by Targeting TOP2A in HCMV-Positive Glioblastoma Cells

Molecules, 2018
Glioblastoma (GBM), the most common type of primary tumor in the central nervous system, is a very aggressive brain tumor with poor prognosis and a high recurrence rate.
Jing-yi Song, Q. Ma, Ming Hu, D. Qian, Bin Wang, Ningning He   +5 more
semanticscholar   +1 more source

Suppressive effects of pterostilbene on human cytomegalovirus (HCMV) infection and HCMV-induced cellular senescence

Virology Journal, 2022
Abstract Background Human cytomegalovirus (HCMV), a member of the β-herpesvirus family, causes the establishment of a latent infection that persists throughout the life of the host and can be reactivated when immunity is weakened.
Sanying Wang, Xuqiang Zhou, Xinyue He, Shushu Ma, Chuan Sun, Jing Zhang, Xiaogang Xu, Weihua Jin, Jin Yan, Ping Lin, Genxiang Mao   +10 more
openaire   +3 more sources

Identification and characterization of human cytomegalovirus-encoded circular RNAs

Frontiers in Cellular and Infection Microbiology, 2022
Circular RNA (circRNA) exists extensively and plays essential roles in serving as microRNA (miRNA) or protein sponges and protein scaffolding in many organisms.
Jingui Deng, Jingui Deng, Qing Wang, Jing Zhang, Jing Zhang, Jing Zhang, Yanping Ma, Yanping Ma, Ying Qi, Ying Qi, Ying Qi, Zhongyang Liu, Zhongyang Liu, Zhongyang Liu, Yibo Li, Yibo Li, Qiang Ruan, Qiang Ruan, Qiang Ruan, Yujing Huang, Yujing Huang, Yujing Huang   +21 more
doaj   +1 more source

HCMV-Encoded NK Modulators: Lessons From in vitro and in vivo Genetic Variation

Frontiers in Immunology, 2018
Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research toward findings of in vivo ...
Mihil Patel, Virginia-Maria Vlahava, Simone K. Forbes, C. Fielding, R. Stanton, E. Wang   +5 more
semanticscholar   +1 more source