Results 71 to 80 of about 28,017 (205)

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source

Large-Scale Screening of HCMV-Seropositive Blood Donors Indicates that HCMV Effectively Escapes from Antibodies by Cell-Associated Spread

Viruses, 2018
Immunoglobulins are only moderately effective for the treatment of human cytomegalovirus (HCMV) infections, possibly due to ineffectiveness against cell-associated virus spread.
J. Falk, M. Winkelmann, Kerstin Laib Sampaio, Caroline Paal, H. Schrezenmeier, M. Alt, R. Stanton, A. Krawczyk, R. Lotfi, C. Sinzger   +9 more
semanticscholar   +1 more source

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources

Adult brain cancer incidence patterns: A comparative study between Japan and Japanese Americans

International Journal of Cancer, Volume 157, Issue 3, Page 436-444, 1 August 2025.
What's new? The risk factors for brain tumors remain largely unknown. Building on the legacy of migration studies, this study compared the incidence of adult malignant brain and central nervous system tumors in Japan and among Japanese Americans and other ethnic populations in the United States.
Byron Sigel, Diana R. Withrow, Lene H. S. Veiga, Eiko Saito, Tomohiro Matsuda, Kota Katanoda   +5 more
wiley   +1 more source

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins [PDF]

, 2017
Using a high throughput screening methodology we surveyed a collection of largely uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) activity.
Beelontally, Rooksarr, Davison, Andrew J., Deng, Xianming, Goodmaker, Charles J., Gray, Nathanael S., Ho, Catherine M.K., Lau, Betty, Strang, Blair L., Swanson, Chad M., Wang, Jinhua, Wilkie, Gavin S.   +10 more
core   +2 more sources

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, Volume 12, Issue 22, June 12, 2025.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming [PDF]

, 2018
Natural Killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated.
Angela Santoni, Angela Santoni, Angela Santoni, Chiara Pighi, Cristina Capuano, Gabriella Palmieri, Lavinia Franchitti, Ombretta Turriziani, Ricciarda Galandrini, Simone Battella, Stefania Morrone   +10 more
core   +2 more sources

Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease [PDF]

arXiv, 2016
The association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n=50; matched related donor (MRD), n=27) underwent whole exome sequencing to identify single ...
arxiv  

The Complex Role of CD8+ T Cells in Placental HIV Infection

European Journal of Immunology, Volume 55, Issue 6, June 2025.
CD8+ T cells exhibit dual roles at the maternal‐fetal interface supporting tolerance via IL‐10 and TGF‐β and aiding implantation and vascular remodeling through TNF‐α and IFN‐γ. In HIV infection, CD8+ T cells expand, driving inflammation, PD‐L1 upregulation on trophoblasts, and cytotoxic dysfunction via reduced Granzyme B and Perforin, compromising ...
Kimberly Peta, Mushi Matjila, Nadia Ikumi   +2 more
wiley   +1 more source

Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways

Cell Death and Disease, 2017
Cancer is a multifactorial disease and virus-mediated carcinogenesis is one of the crucial factors, which is poorly understood. Human cytomegalovirus (HCMV) is a herpesvirus and its components have been evidenced to be associated with cancer of different
P. Kumari, Irene Saha, Athira Narayanan, Sathish Narayanan, A. Takaoka, N. S. Kumar, Prafullakumar Tailor, H. Kumar   +7 more
semanticscholar   +1 more source