Cancer Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background Resistance to 5‐fluorouracil (5‐FU) remains a major obstacle in colorectal cancer (CRC) treatment. Trifluridine (FTD), the active component of TAS‐102, exerts cytotoxicity through DNA incorporation and reportedly remains active in 5‐FU‐resistant tumors, though with limited clinical efficacy.
Shuhei Uehara +11 more
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Study of caspase-6 activity in aggressive HCT116 cells using methotrexate-encapsulated lactoferrin-conjugated solid lipid nanoparticles via in silico and in vitro approaches. [PDF]
Sci RepBhattacharya S +3 more
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Role of Episamarcandin in Promoting the Apoptosis of Human Colon Cancer HCT116 Cells through the PI3K-Akt Signaling Pathway. [PDF]
Evid Based Complement Alternat Med, 2021 Zhang H, Sun J, Ma R, Zhao S.
europepmc +1 more source
Cancer Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background Glioblastoma (GBM) is a common brain cancer with a poor prognosis and a high recurrence rate. DNA damage repair plays a crucial role in GBM carcinogenesis and treatment resistance. Human endogenous bornavirus‐like nucleoprotein 1 (EBLN1) regulates cellular processes and genetic stability. However, the biological role of EBLN1 in GBM
Jing Liang +6 more
wiley +1 more source
Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells. [PDF]
Sci Repvan Zyl E +4 more
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Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
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The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from Apostichopus japonicus on Human Colon Cancer HCT116 Cells. [PDF]
MoleculesZhang Y +8 more
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Harmine Hydrochloride Triggers G2/M Cell Cycle Arrest and Apoptosis in HCT116 Cells through ERK and PI3K/AKT/mTOR Signaling Pathways. [PDF]
Prev Nutr Food Sci, 2021 Kim GD.
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MicroRNA Profiling of Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells [PDF]
Oncomedicine, 2017 Bustamin Kosmo +9 more
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Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong +6 more
wiley +1 more source