Results 101 to 110 of about 276,656 (346)

National Trends in Utilization and 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys.

Journal of the American Society of Nephrology, 2019
BACKGROUND Recent pilot trials have demonstrated the safety of transplanting HCV-viremic kidneys into HCV-seronegative recipients. However, it remains unclear if allograft function is impacted by donor HCV-viremia or recipient HCV-serostatus.
V. Potluri, D. Goldberg, S. Mohan, R. Bloom, D. Sawinski, P. Abt, E. Blumberg, C. Parikh, James E. Sharpe, K. Reddy, M. Molnar, M. Molnar, M. Sise, P. Reese   +13 more
semanticscholar   +1 more source

Built-in bias in HCV clearance in acute HCV infection

Journal of Hepatology, 2014
To the Editor:We read with interest the recent paper about hepatitis C virus(HCV) clearance in patients with acute HCV infection [1].Weare wondering why authors did not calculate risk ratio insteadof odds ratio (OR) when they have run a cohort study? Theycan present how much is the incidence of HCV clearance and rel-ative risk (RR) of factors affecting
Ali Kabir, Davood Khalili
openaire   +3 more sources

Prevalence of Resistance-Associated Substitutions in HCV NS5A, NS5B, or NS3 and Outcomes of Treatment With Ledipasvir and Sofosbuvir.

Gastroenterology, 2016
BACKGROUND & AIMS We evaluated the effects of baseline hepatitis C virus (HCV) NS5A, NS5B, and NS3 resistance-associated substitutions (RASs) on response to the combination of ledipasvir and sofosbuvir, with or without ribavirin, in patients with HCV ...
C. Sarrazin, H. Dvory‐Sobol, E. Svarovskaia, B. Doehle, P. Pang, S. Chuang, Julie Ma, Xiao Ding, N. Afdhal, K. Kowdley, E. Gane, E. Lawitz, D. Brainard, J. Mchutchison, Michael D. Miller, H. Mo   +15 more
semanticscholar   +1 more source

Dynamic protein interactions probed by NMR spectroscopy

Bulletin of the Korean Chemical Society, EarlyView.
Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley   +1 more source

Hepatitis G Virus Infection in Patients with Hepatitis C

Journal of High Institute of Public Health, 2010
Hepatitis G virus (HGV) infection is a worldwide health problem causing acute and chronic non A- E hepatitis. Because HGV and hepatitis C virus (HCV) share same modes of transmission, co-infection with the two viruses is not uncommon especially among ...
Heba S. Selim, Mohamed A.El Barrawy, Osama N. Mohamed, Marwa S. Gamal El Din   +3 more
doaj   +1 more source

ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV.

New England Journal of Medicine, 2014
BACKGROUND The interferon-free regimen of ABT-450 with ritonavir (ABT-450/r), ombitasvir, and dasabuvir with or without ribavirin has shown efficacy in inducing a sustained virologic response in a phase 2 study involving patients with hepatitis C virus ...
P. Ferenci, D. Bernstein, J. Lalezari, D. Cohen, Yan Luo, C. Cooper, E. Tam, R. Marinho, N. Tsai, A. Nyberg, T. Box, Z. Younes, P. Enayati, Sinikka Green, Y. Baruch, B. Bhandari, F. Căruntu, T. Sepe, Vladimir P Chulanov, E. Janczewska, G. Rizzardini, J. Gervain, R. Planas, Christophe Moreno, T. Hassanein, W. Xie, M. King, T. Podsadecki, K. Reddy   +28 more
semanticscholar   +1 more source

Innate immunity and HCV

Journal of Hepatology, 2013
Hepatitis C virus (HCV) infections become chronic in the majority of infected individuals, and chronic hepatitis C (CHC) can lead to cirrhosis and hepatocellular carcinoma. The innate immune system is central to host-virus interactions during the entire natural course of the disease.
openaire   +4 more sources

Global trends and epidemiological shifts in gastrointestinal cancers: insights from the past four decades

Cancer Communications, EarlyView.
Abstract Background The epidemiological profiles of gastrointestinal (GI) cancers vary across countries and over time, largely reflecting variations in risk factors and screening practices. We aimed to provide an overview of the current global burden of the five major types of GI cancers and conduct an updated evaluation of the long‐term trends of GI ...
Mengmeng Li, Sumei Cao, Rui‐Hua Xu
wiley   +1 more source

Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1.

New England Journal of Medicine, 2015
BACKGROUND Effective treatment for hepatitis C virus (HCV) in patients coinfected with human immunodeficiency virus type 1 (HIV-1) remains an unmet medical need.
S. Naggie, C. Cooper, M. Saag, K. Workowski, P. Ruane, W. Towner, K. Marks, A. Luetkemeyer, R. Baden, P. Sax, E. Gane, Jorge Santana-Bagur, L. Stamm, Jenny C. Yang, P. German, H. Dvory‐Sobol, Liyun Ni, P. Pang, J. Mchutchison, C. Stedman, J. Morales-Ramirez, N. Bräu, D. Jayaweera, A. Colson, P. Tebas, D. Wong, D. Dieterich, M. Sulkowski   +27 more
semanticscholar   +1 more source

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
wiley   +1 more source