Results 41 to 50 of about 434,626 (386)

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Gastroenterology, 2019
BACKGROUND & AIMS: Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is decreased but not eliminated after a sustained virologic response (SVR)
Nourdine Hamdane, Frank Jühling, E. Crouchet, Houssein El Saghire, C. Thumann, Marine A. Oudot, S. Bandiera, Antonio Saviano, C. Ponsolles, A. A. Roca Suarez, Shen Li, N. Fujiwara, A. Ono, I. Davidson, N. Bardeesy, Christian Schmidl, C. Bock, C. Schuster, J. Lupberger, F. Habersetzer, M. Dofföel, T. Piardi, D. Sommacale, M. Imamura, Takuro Uchida, H. Ohdan, H. Aikata, K. Chayama, T. Boldanova, P. Pessaux, B. Fuchs, Y. Hoshida, M. Zeisel, F. Duong, T. Baumert   +34 more
semanticscholar   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Molecular Evaluation of Viral load and Genotype of HCV in Acute and Chronic HCV Patients in Kirkuk City [PDF]

Kirkuk Journal of Science, 2019
The study aimed at detection of HCV load and genotypes in acute and chronic HCV patients. A cross sectional study was carried out in Kirkuk city from 15th of March 2017 to 15th of November 2017.
Israa Saadoon, Thekra Hamada, Muhannad Alazzawy   +2 more
doaj   +1 more source

Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?

, 2013
BACKGROUND: Amongst injecting drug users (IDUs), HIV is transmitted sexually and parenterally, but HCV is transmitted primarily parenterally. We assess and model the antibody prevalence of HCV amongst HIV-infected IDUs (denoted as HCV-HIV co-infection ...
Beattie, Tara, EMCDDA Collaborative Group, Hickman, Matthew, Jarlais, Don Des, Martin, Natasha K, Roy, Anuradha, Strathdee, Steffanie, Vickerman, Peter, Wiessing, Lucas   +8 more
core   +1 more source

Improving Surveillance of Hepatitis C Infections Among Patients Receiving Medication Treatment for Opioid Use Disorder [PDF]

, 2020
Background: Despite harm reduction efforts, Hepatitis C virus (HCV) infections among individuals with opioid use disorder tripled between 2010 and 2015 in the US.
Bray, Jacqueline
core   +1 more source

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models [PDF]

, 2010
Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer ...
Bukh, Jens, Eder, Gerald, Engle, Ronald E, Feinstone, Stephen M, Govindarajan, Sugantha, Krawczynski, Krzysztof, Leroux-Roels, Geert, Meuleman, Philip, Miller, Roger H, Purcell, Robert H, Satterfield, William C, Tellier, Raymond   +11 more
core   +1 more source

Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis.

New England Journal of Medicine, 2014
BACKGROUND High rates of sustained virologic response were observed among patients with hepatitis C virus (HCV) infection who received 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor ledipasvir ...
K. Kowdley, S. Gordon, K. Reddy, L. Rossaro, D. Bernstein, E. Lawitz, M. Shiffman, E. Schiff, R. Ghalib, M. Ryan, V. Rustgi, M. Chojkier, R. Herring, A. D. Di Bisceglie, P. Pockros, G. Subramanian, D. An, E. Svarovskaia, R. Hyland, P. Pang, W. Symonds, J. Mchutchison, A. Muir, D. Pound, M. Fried   +24 more
semanticscholar   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.

Gastroenterology, 2017
BACKGROUND & AIMS Patients with chronic hepatitis C virus (HCV) infection have high rates of sustained virologic response (SVR) after 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor velpatasvir ...
Ira M. Jacobson, E. Lawitz, E. Gane, B. Willems, P. Ruane, R. Nahass, S. Borgia, S. Shafran, K. Workowski, Brian L. Pearlman, R. Hyland, L. Stamm, E. Svarovskaia, H. Dvory‐Sobol, Yanni Zhu, G. Subramanian, D. Brainard, J. Mchutchison, N. Bräu, T. Berg, K. Agarwal, B. Bhandari, Mitchell N. Davis, J. Feld, G. Dore, C. Stedman, A. Thompson, T. Asselah, S. Roberts, G. Foster   +29 more
semanticscholar   +1 more source