Results 61 to 70 of about 273,364 (223)
Canada Communicable Disease Report, 2021 Hepatitis C continues to be a significant public health concern in Canada, with the hepatitis C virus (HCV) responsible for more life-years lost than all other infectious diseases in Canada.
Lillian Lourenço +6 more
doaj +1 more source
Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients.
New England Journal of Medicine, 2017 An open-label pilot trial involving 10 patients shows that hepatitis C virus genotype 1–infected kidneys transplanted into HCV-negative recipients, followed by direct-acting antiviral therapy, can result in excellent allograft function with cure of HCV ...
David S. Goldberg +19 more
semanticscholar +1 more source
Association of Codon 72 of P53 Gene Polymorphism with Chronic Hepatitis C Virus Infection: A Case Control Study [PDF]
Journal of Cell and Molecular Research, 2016 Single nucleotide polymorphism in codon 72 of p53 gene (Arg/Pro) changes p53 protein structure and affects its activities. Hepatitis C virus (HCV) is believed to induce hepatocellular carcinoma and P53 polymorphisms have been associated with human ...
Sina Gerayli +8 more
doaj +1 more source
Journal of Acquired Immune Deficiency Syndromes, 2016 Objective:A recent HIV outbreak in a rural network of persons who inject drugs (PWID) underscored the intersection of the expanding epidemics of opioid abuse, unsterile injection drug use (IDU), and associated increases in hepatitis C virus (HCV ...
Michelle M. Van Handel +15 more
semanticscholar +1 more source
Predictability of IL-28B-polymorphism on protease-inhibitor-based triple-therapy in chronic HCV-genotype-1 patients: A meta-analysis [PDF]
World Journal of Hepatology, 6(10):759-765, 2014, 2014 AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and pegylated interferon-$\alpha$ (Peg-INF-$\alpha$) based triple-therapy.
arxiv +1 more source
A pharmacokinetic -- viral kinetic model describes the effect of alisporivir monotherapy or in combination with peg-IFN on 2 hepatitis C virologic response [PDF]
Clinical Pharmacology and Therapeutics, American Society for
Clinical Pharmacology and Therapeutics, 2014, 96 (5), pp.599-608, 2015 Alisporivir is a cyclophilin inhibitor with demonstrated in vitro and in vivo activity against hepatitis C 11 virus (HCV). We estimated antiviral effectiveness of alisporivir alone or in combination with 12 pegylated-Inteferon (peg-IFN) in 88 patients infected with different HCV genotypes treated for four 13 weeks.
arxiv +1 more source
Pakistan Armed Forces Medical Journal, 2020 Objective: To determine the rates of HCV seroconversion in patients undergoing hemodialysis (HD) in dialysis units of tertiary care hospitals. Study Design: Descriptive cross-sectional study.
Muhammad Asif +5 more
doaj
NKG2A is a NK cell exhaustion checkpoint for HCV persistence
Nature Communications, 2019 Exhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined ...
Chao Zhang +14 more
semanticscholar +1 more source
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Clinical Infectious Diseases, 2016 Epidemiological data and modeling suggest a continuing hepatitis C virus (HCV) epidemic among human immunodeficiency virus-diagnosed men who have sex with men in the United Kingdom.
N. Martin +12 more
semanticscholar +1 more source