Results 61 to 70 of about 276,656 (346)

Sero-epidemiology of human immunodeficiency virus, hepatitis B virus and hepatitis C virus: a cross-sectional survey in a rural setting of the West region of Cameroon

The Pan African Medical Journal, 2017
INTRODUCTION: human immunodeficiency Virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are the three most common chronic viral infections worldwide, specifically in sub-Saharan Africa (SSA).
Jobert Richie Nansseu, Descartes Maxime Mbogning, Gwladys Chavely Monamele, Stive Fokam Tamoh, Hortense Kamga Gonsu, Charles Kouanfack, Yves Nathan Yanwou, Zacharie Sando   +7 more
doaj   +1 more source

Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis.

New England Journal of Medicine, 2015
BACKGROUND As the population that is infected with the hepatitis C virus (HCV) ages, the number of patients with decompensated cirrhosis is expected to increase.
Michael P. Curry, J. O’Leary, N. Bzowej, A. Muir, K. Korenblat, J. Fenkel, K. Reddy, E. Lawitz, S. Flamm, T. Schiano, L. Teperman, R. Fontana, EugeneR. Schiff, M. Fried, B. Doehle, D. An, J. McNally, A. Osinusi, D. Brainard, J. Mchutchison, Robert S. Brown, Michael Charlton   +21 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.

Gastroenterology, 2017
BACKGROUND & AIMS Patients with chronic hepatitis C virus (HCV) infection have high rates of sustained virologic response (SVR) after 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor velpatasvir ...
Ira M. Jacobson, E. Lawitz, E. Gane, B. Willems, P. Ruane, R. Nahass, S. Borgia, S. Shafran, K. Workowski, Brian L. Pearlman, R. Hyland, L. Stamm, E. Svarovskaia, H. Dvory‐Sobol, Yanni Zhu, G. Subramanian, D. Brainard, J. Mchutchison, N. Bräu, T. Berg, K. Agarwal, B. Bhandari, Mitchell N. Davis, J. Feld, G. Dore, C. Stedman, A. Thompson, T. Asselah, S. Roberts, G. Foster   +29 more
semanticscholar   +1 more source

HCV Extrahepatic Manifestations [PDF]

Journal of Clinical and Translational Hepatology, 2019
Hepatitis C virus (HCV) has been shown to affect many tissues other than liver. However, of the many extrahepatic manifestations (EMs) that have been associated with HCV, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes and neurological disorders, only a few have been shown to be directly related to HCV infection of ...
Martina Smolić, Robert Smolić, George Y. Wu, Lucija Kuna, Jelena Jakab   +4 more
openaire   +3 more sources

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Peg-interferon plus ribavirin in chronic hepatitis C: cost-efficacy and pharmacoutilization in clinical practice

Farmeconomia: Health Economics and Therapeutic Pathways, 2008
The current standard of care for the treatment of chronic hepatitis C virus (HCV) infection is combination therapy with Peg-interferon (IFN) alpha-2a or alpha-2b type plus ribavirin (RBV).
Luisa Cavalletto, Elisabetta Bernardinello, Giulio Diodati, Enzo Raise, Angelo Gatta, Liliana Chemello   +5 more
doaj   +1 more source

Digital Bioassays on the Slipchip Microfluidic Devices

Advanced Sensor Research, EarlyView.
This review summarizes recent advances in SlipChip‐based digital bioassays, highlighting their simple “load and slip” operation for fluid partitioning which eliminate the need for sophisticated fluidic systems. Applications include digital nucleic acid analysis, digital protein analysis and single‐cell analysis, demonstrating the platform‘s potential ...
Qingqing Luo, Ziqing Yu, Weiyuan Lyu, Yang Luo, Lei Xu, Feng Shen   +5 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

CCR5Δ32 in HCV infection, HCV/HIV co-infection, and HCV-related diseases

Infection, Genetics and Evolution, 2018
Although a potential involvement of the CCR5Δ32 variant has already been suggested in relation to susceptibility to hepatitis C virus (HCV) infection, data from the literature is still quite controversial. Thus, our study evaluated the influence of the CCR5Δ32 allele variant in HCV infection, HCV/HIV co-infection, and HCV-related diseases in ...
Joel Henrique Ellwanger, Bruna Kulmann Leal, Jacqueline María Valverde-Villegas, Daniel Simon, Camila Guerra Marangon, Vanessa Suñé Mattevi, Rosmeri Kuhmmer Lazzaretti, Eduardo Sprinz, Regina Kuhmmer, José Artur Bogo Chies   +9 more
openaire   +3 more sources