Results 81 to 90 of about 276,656 (346)

Association of Codon 72 of P53 Gene Polymorphism with Chronic Hepatitis C Virus Infection: A Case Control Study [PDF]

Journal of Cell and Molecular Research, 2016
Single nucleotide polymorphism in codon 72 of p53 gene (Arg/Pro) changes p53 protein structure and affects its activities. Hepatitis C virus (HCV) is believed to induce hepatocellular carcinoma and P53 polymorphisms have been associated with human ...
Sina Gerayli, Alireza Pasdar, Sina Rostami, Samaneh Sepahi, Seyed Mousalreza Hoseini, Reza Jahanian, Aida Gholoobi, Zahra Meshkat, Mitra Ahadi   +8 more
doaj   +1 more source

NKG2A is a NK cell exhaustion checkpoint for HCV persistence

Nature Communications, 2019
Exhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined ...
Chao Zhang, Xiao-mei Wang, Shu-ran Li, Trix Twelkmeyer, Wei-hong Wang, Sheng-yuan Zhang, Shu-feng Wang, Ji-zheng Chen, Xia Jin, Yuzhang Wu, Xin-wen Chen, Sheng-dian Wang, J. Niu, Hairong Chen, Hong Tang   +14 more
semanticscholar   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source

HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine the rates of HCV seroconversion in patients undergoing hemodialysis (HD) in dialysis units of tertiary care hospitals. Study Design: Descriptive cross-sectional study.
Muhammad Asif, Muhammad Zahid, Raheel Ahmad, Zafar Mehmood, Zia -Ud- Din, Ali Muhammad   +5 more
doaj  

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Can Hepatitis C Virus (HCV) Direct-Acting Antiviral Treatment as Prevention Reverse the HCV Epidemic Among Men Who Have Sex With Men in the United Kingdom? Epidemiological and Modeling Insights

Clinical Infectious Diseases, 2016
Epidemiological data and modeling suggest a continuing hepatitis C virus (HCV) epidemic among human immunodeficiency virus-diagnosed men who have sex with men in the United Kingdom.
N. Martin, A. Thornton, M. Hickman, C. Sabin, M. Nelson, G. Cooke, T. Martin, V. Delpech, M. Ruf, H. Price, Y. Azad, E. Thomson, P. Vickerman   +12 more
semanticscholar   +1 more source

HCV and cryoglobulinemic vasculitis.

Cleveland Clinic Journal of Medicine, 2002
munoglobulinemia)or more immunoglobulins (mixedcryoglobulinemia), which precipitate at temperaturesbelow 37 °C and redissolve on re-warming is termed“cryoglobulinemia.” This is an in vitro phenomenon; theactual mechanism(s) of cryoprecipitation remains obscure.It could be secondary to intrinsic characteristics ofboth mono- and polyclonal immunoglobulin
FERRI, Clodoveo, Zignego AL, Giuggioli D, SEBASTIANI, Marco, Cazzato M, Antonelli A, La Civita L, Fadda P, Longombardo G, Pileri S.   +9 more
openaire   +6 more sources

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin.

New England Journal of Medicine, 2014
BACKGROUND The interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r) and the NS5A inhibitor ombitasvir (also known as ABT-267) plus the nonnucleoside polymerase inhibitor dasabuvir (also known as ABT-333) and ribavirin ...
J. Feld, K. Kowdley, E. Coakley, S. Sigal, D. Nelson, D. Crawford, O. Weiland, H. Aguilar, J. Xiong, T. Pilot-matias, Barbara DaSilva-Tillmann, L. Larsen, T. Podsadecki, B. Bernstein   +13 more
semanticscholar   +1 more source