Results 1 to 10 of about 134,666 (283)
Differential effects of HDAC inhibitors in the Rho I255d mouse model for autosomal dominant retinitis pigmentosa [PDF]
Cell Death DiscoveryRetinitis Pigmentosa (RP) is an inherited neurodegenerative disease which leads to loss of retinal photoreceptors and blindness. Histone deacetylases (HDAC) were previously found to be involved in photoreceptor cell death, and HDAC inhibitors have shown ...
Yu Zhu +3 more
doaj +2 more sources
Next-Generation HDAC Inhibitors: Advancing Zinc-Binding Group Design for Enhanced Cancer Therapy [PDF]
CellsHistone deacetylases (HDACs) are pivotal epigenetic regulators that control gene expression, cell proliferation, and differentiation, and their dysregulation is closely associated with the onset and progression of multiple cancers.
Mohammed Hawash
doaj +2 more sources
The Effect of Quisinostat as the HDAC Inhibitor on Migration [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021 Background and Aim: Cancer cannot be explained only by genetic alterations but involves epigenetic processes. Modifying histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between Histone ...
Marjan Hajimoradi Javarsiani +2 more
doaj +3 more sources
EFFECT OF SAHA AND C-JUN N-TERMINAL KINASE INHIBITOR ON THE INDUCIBLE MRNA EXPRESSION OF INTERLEUKIN-17 [PDF]
Journal of IMAB, 2023 Interleukin-17 (IL-17A) is a critical cytokine for immune defence against extracellular bacterial and fungal infections. Excess production during chronic inflammation has been associated with many inflammatory and autoimmune disorders. On the other hand,
Boncho Grigorov +4 more
doaj +1 more source
Evaluation of histone deacetylase inhibitory and antiproliferative activity of piperine and its derivatives [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 Piperine (1) was obtained from the seeds of Piper nigrum L. It could act as a pan-histone deacetylase (HDAC) inhibitor. This lead compound was structurally modified to six derivatives that exhibited improved HDAC inhibitory activity.
La-or Somsakeesit +6 more
doaj +1 more source
Recent developments of HDAC inhibitors: Emerging indications and novel molecules
British Journal of Clinical Pharmacology, 2021 The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically well established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a high number of clinical trials ...
A. D. Bondarev +5 more
semanticscholar +1 more source
Indonesian Journal of Chemistry, 2022 The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT).
Gunasingham Parthiban +4 more
doaj +1 more source
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Nature Chemical Biology, 2022 Drugs that target histone deacetylase (HDAC) entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a quantitative chemical proteomics assay using immobilized HDAC inhibitors and mass ...
Severin Lechner +24 more
semanticscholar +1 more source
Cancers, 2021 Simple Summary Beyond mutations, epigenetic changes have been described as drivers for cancer as well. While leaving the overall DNA structure intact, they can be responsible for tumor malignancy by mediating the transcriptional upregulation of oncogenes.
R. Jenke +4 more
semanticscholar +1 more source
Cancer Research, 2021 The dual PI3K/HDAC inhibitor BEBT-908 elicits potent anti-tumor responses, effectively inducing immunogenic ferroptosis of tumor cells and potentiating cancer immunotherapy.
F. Fan +11 more
semanticscholar +1 more source