Results 151 to 160 of about 116,207 (325)

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Overcoming reduced glucocorticoid sensitivity in airway disease:molecular mechanisms and therapeutic approaches [PDF]

, 2010
Abraham, Adcock, Ali, Allfrey, Auphan, Barnes, Barnes, Barnes, Barnes, Bartholome, Bartling, Bartling, Bateman, Beesley, Bergeron, Bhavsar, Bhavsar, Bourbeau, Cai, Calverley, Carmichael, Carrabino, Charmandari, Chen, Cho, Chung, Chung, Chung, Ciencewicki, Condliffe, Cosio, Cosio, Culpitt, Culpitt, Denslow, Duma, Evans, Ferreira, Fitzpatrick, Freedman, Gagliardo, Galasinski, Galliher-Beckley, Galliher-Beckley, Goleva, Gross, Gross, Hakonarson, Haller, Hew, Hogg, Hwang, Ian M. Adcock, Irusen, Ito, Ito, Ito, Ito, Ito, Ito, Jatakanon, John, John A. Marwick, Karp, Keatings, Kian Fan Chung, King, Kino, Kitagawa, Kleiman, Knoepfler, Konstan, Korn, Kovacs, Krstic, Kumar, Kumar, Kurashima, Laffargue, Langhoff, Lee, Lee, Lewis-Tuffin, Li, Li, Liu, Lu, Macedo, Mak, Mannino, Marone, Marwick, Marwick, Marwick, Marwick, Marwick, Matysiak, Meagher, Medicherla, Meja, Miller, Molnarfi, Moore, Murphy, Muselet-Charlier, Onda, Osoata, OʼSullivan, Pace, Patel, Pratt, Pujols, Pujols, Rahman, Rahman, Raia, Reichardt, Renda, Rennard, Rhen, Rogatsky, Rommel, Rottner, Rumora, Saccani, Sadhu, Sasaki, Schacke, Scheinman, Schermer, Sethi, Silverstein, Smith, Smolonska, Stav, Strickland, Suissa, Szatmuíry, Thomson, Tomlinson, Tuckermann, Tudhope, Ukena, Usmani, van Rensen, Verhaeghe, Ward, Ward, Wood, Wright, Young   +150 more
core   +1 more source

DIPG-74. TARGETING TRANSCRIPTIONAL DYSREGULATION IN DMG THROUGH CDK9 AND HDAC INHIBITOR COMBINATION THERAPY [PDF]

Brittany R Eberl, Rebecca Murdaugh, Adanze N Nnyagu, Rosemary Richard, Benjamin Deneen, Kwanha Yu, Jamie N. Anastas   +6 more
openalex   +1 more source

Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52 [PDF]

, 2017
Chih‐Cheng Chen, Ju-Sui Huang, Tong‐Hong Wang, Chen-Hsin Kuo, Chia-Jen Wang, Shu‐Huei Wang, Yann‐Lii Leu   +6 more
openalex   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients [PDF]

Chiara Mozzetta, Vittorio Sartorelli, Christian Steinkühler, Prem Puri   +3 more
openalex   +1 more source

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

, 2022
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo   +8 more
openalex   +1 more source

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F‐actin signalling pathway

, 2021
Qian Chen, Yao Wang, Fangzhou Jiao, Pan Cao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong   +7 more
openalex   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source