Results 181 to 190 of about 116,207 (325)

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Journal of Periodontal Research, EarlyView.
BDMP, a peptide that can penetrate cells and tissues, offering antimicrobial and anti‐inflammatory effects, has been identified as a potential new therapy for periodontitis. ABSTRACT Aim This study evaluated the potential of a beta‐defensin‐3 mimetic peptide (BDMP), a synthetic cell‐penetrating peptide with antimicrobial and immunomodulatory properties,
Beom Soo Jo, Dong Woo Lee, Ji‐Young Lee, Sanghui Seok, Yu‐Bin Kim, Jue‐Yeon Lee, Shin‐Young Park, Young Dan Cho, Yang Jo Seol, Yoon Shin Park, Shahram Ghanaati, Homayoun H. Zadeh, Chong Pyung Chung, Yoon Jeong Park   +13 more
wiley   +1 more source

The environmentally responsive plant epigenome: insights from jasmonate signaling

New Phytologist, EarlyView.
Summary The environmental responsiveness of the plant epigenome is essential for spatiotemporally precise gene regulation, enabling plants to adapt to external cues. Elucidating the mechanisms underlying this responsiveness is therefore fundamental to deciphering the molecular logic of plant‐environment interactions.
Mark Zander, Emily Vesper
wiley   +1 more source

A Novel Class I HDAC Inhibitor, AW01178, Inhibits Epithelial–Mesenchymal Transition and Metastasis of Breast Cancer [PDF]

Xiangxiang Liu, Yawen Chen, Li Yang, Shen Ying, Shasha Dong, Jiang Tan   +5 more
openalex   +1 more source

Figure legends from Death by HDAC Inhibition in Synovial Sarcoma Cells

, 2023
Aimée N. Laporte, Neal Poulin, Jared J. Barrott, Xiu Qing Wang, Alireza Lorzadeh, Ryan Vander Werff, Kevin B. Jones, T. Michael Underhill, Torsten O. Nielsen   +8 more
openalex   +1 more source

MS275 as Class I HDAC inhibitor displayed therapeutic potential on malignant ascites by iTRAQ-based quantitative proteomic analysis [PDF]

, 2022
Li Du, Dongyuan Wang, Xiuqi Wei, Chang Liu, Zhuanglong Xiao, Wei Qian, Yuhu Song, Xiaohua Hou   +7 more
openalex   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source

Histone deacetylase (HDAC) [PDF]

Science-Business eXchange, 2009
  +7 more sources

Phosphatidylinositol-3-Kinase (PI3K) and Histone Deacetylase (HDAC) Multitarget Inhibitors: An Update on Clinical and Preclinical Candidates. [PDF]

Pharmaceuticals (Basel)
Lima ADS, Lima LM.
europepmc   +1 more source

Supplementary Material -Table Legends, Figures and Legends 1-3 from Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma

, 2023
Jeffim N. Kuznetsoff, Dawn A. Owens, Andy Lopez, Daniel A. Rodriguez, Nancy T. Chee, Stefan Kurtenbach, Daniel Bilbao, Evan R. Roberts, Claude‐Henry Volmar, Claes Wahlestedt, Shaun P. Brothers, J. William Harbour   +11 more
openalex   +2 more sources

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source