Results 11 to 20 of about 116,207 (325)
Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology Perspective [PDF]
Metabolites, 2021 Histone deacetylases (HDACs) are epigenetic enzymes that play a central role in gene regulation and are sensitive to the metabolic state of the cell. The cross talk between metabolism and histone acetylation impacts numerous biological processes including development and immune function.
Jacob King +2 more
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HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag [PDF]
PeerJ, 2023 Purpose This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6brd1 mice, a model of retinitis pigmentosa (RP).
Yujie Dong +5 more
doaj +2 more sources
Epigenetic regulation by gut microbiota
Gut Microbes, 2022 The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host.
Vivienne Woo, Theresa Alenghat
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Archives of Medical Science, 2021 Introduction The objective of this study was to explore the role of curcumin (CUR) in the control of renal cell carcinoma (RCC) as well as the molecular mechanism underlying the effect of CUR.
Fuhe Liu +7 more
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Dual Inhibitors Targeting DNA and Histone Deacetylases
Pharmaceutical Fronts, 2020 Histone deacetylases (HDACs) regulate the acetylation status of histones and structural status of chromatin. The chromatin structure becomes relaxed after inhibition of HDAC, leading to DNA exposed to DNA disrupting agents, and eventually causing DNA ...
Chen Chen +3 more
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HDACs and HDAC Inhibitors in Cancer Development and Therapy [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 Over the last several decades, it has become clear that epigenetic abnormalities may be one of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play a crucial role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear architecture.
Yixuan, Li, Edward, Seto
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Pathogens, 2020 Epigenetic reprogramming in macrophages is termed trained innate immunity, which regulates immune tolerance and limits tissue damage during infection. Neisseria gonorrhoeae is a strict human pathogen that causes the sexually transmitted infection termed ...
Susu M. Zughaier +2 more
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Histone deacetylases (HDACs): characterization of the classical HDAC family [PDF]
Biochemical Journal, 2003 Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational modification of histones, the building blocks of chromatin, such as methylation, phosphorylation and acetylation. Acetylation is probably the best understood of these modifications: hyperacetylation leads to an increase in ...
Annemieke J M, de Ruijter +4 more
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Сибирский онкологический журнал, 2020 The purpose of the study was to analyze the ability of five antitumor drugs from the pharmaceutical group of protein kinase inhibitors (gefitinib, imatinib, pazopanib, ponatinib and enzastaurin) to reactivate the expression of the epigenetically silenced
V. P. Maksimova +11 more
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Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy. [PDF]
, 2017 BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease ...
A Cevik +49 more
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