Results 11 to 20 of about 134,666 (283)
Epigenetic regulation by gut microbiota
Gut Microbes, 2022 The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host.
Vivienne Woo, Theresa Alenghat
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Archives of Medical Science, 2021 Introduction The objective of this study was to explore the role of curcumin (CUR) in the control of renal cell carcinoma (RCC) as well as the molecular mechanism underlying the effect of CUR.
Fuhe Liu +7 more
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The efficacy of HDAC inhibitors in neoplasm treatment
Journal of Education, Health and Sport, 2020 Introduction and purpose: Histone Deacetylases (HDACs) are associated with epigenetic regulation of gene expression. They are responsible of adequate action of not only histone proteins, but also crucial cell cycle proteins, such as p53, NF‐κB or alpha ...
Dominika Psiuk +4 more
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HDAC inhibitors: Targets for tumor therapy, immune modulation and lung diseases
Translational Oncology, 2021 Highlights • HDACs are dysregulated in various malignancies and in some inflammatory lung diseases.• HDAC inhibitors are emerging as a successful epigenetic therapy by exploiting pathophysiology of tumor microenvironment.• HDAC inhibitors can activate ...
G. Shanmugam, S. Rakshit, Koustav Sarkar
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Therapeutic potential of tucidinostat, a subtype-selective HDAC inhibitor, in cancer treatment
Frontiers in Pharmacology, 2022 Histone deacetylase (HDAC) is one of the most characterized epigenetic modifiers, modulating chromatin structure and gene expression, which plays an important role in cell cycle, differentiation and apoptosis.
Yichen Sun +6 more
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Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors
Molecules, 2020 The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and ...
Regina Martínez +9 more
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HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag [PDF]
PeerJ, 2023 Purpose This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6brd1 mice, a model of retinitis pigmentosa (RP).
Yujie Dong +5 more
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Сибирский онкологический журнал, 2020 The purpose of the study was to analyze the ability of five antitumor drugs from the pharmaceutical group of protein kinase inhibitors (gefitinib, imatinib, pazopanib, ponatinib and enzastaurin) to reactivate the expression of the epigenetically silenced
V. P. Maksimova +11 more
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Tumor Anti-Initiation and Anti-Progression Properties of Sulphated-Extract of Colocasia esculenta
Polish Journal of Food and Nutrition Sciences, 2021 Colocasia esculenta (Taro) is an edible tuberous plant; however, corms are its most worldwide consumed part while the corm powder is widely used in food industries. In this work, a sulphated polysaccharide extract of C.
Amira M. Gamal-Eldeen +6 more
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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8.
Samir Mehndiratta +6 more
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