Results 191 to 200 of about 116,207 (325)

HDAC inhibitors as anticancer drugs: chemical diversity, clinical trials, challenges and perspectives. [PDF]

RSC Adv
Abdallah AE.
europepmc   +1 more source

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, EarlyView.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Epigenetic Dysregulation in Neurodegeneration: The Role of Histone Deacetylases and Emerging Inhibitor Strategies. [PDF]

Biomolecules
Pawar Y, Kopranovic A, C S R, Meyer-Almes FJ.   +3 more
europepmc   +1 more source

Discovery of Cloxiquine Derivatives as Multi-Target Hdac Inhibitors for the Treatment of Melanoma Via Activating Pparγ

Limin Yang, Ran Ding, Tong Xiao-jie, Sheng Tong, Shuting Jia, Xiqing Yan, Chong Zhang, Liqiang Wu   +7 more
openalex   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, EarlyView.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source

The central benefit of physiologically induced ketogenic states

The Journal of Physiology, EarlyView.
Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco, Giuseppe Petito, Rosalba Senese, Maria Moreno, Assunta Lombardi, Antonia Lanni, Pieter de Lange   +6 more
wiley   +1 more source

Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook. [PDF]

Front Genet
Lv LZ, Wang ZD, Ren JJ, Li LH, Liu XB, Li JL, Zhu H, Jiang B, Han YP, Zhou XM, Ren L, Chang Z.   +11 more
europepmc   +1 more source

Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation

, 2015
Erica B. Esrick, Marie McConkey, Katherine I. Lin, Alyse Frisbee, Benjamin L. Ebert   +4 more
openalex   +1 more source

Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition

The Journal of Physiology, EarlyView.
Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley   +1 more source

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity

, 2016
Raffaella Cincinelli, Vincent Zwick, Loana Musso, Valentina Zuco, Michelandrea De Cesare, Franco Zunino, Cláudia A. Simões‐Pires, Alessandra Nurisso, Giuseppe Giannini, Muriel Cuendet, Sabrina Dallavalle   +10 more
openalex   +2 more sources