Results 271 to 280 of about 116,207 (325)

From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma

Cancer Science, Volume 117, Issue 2, Page 289-296, February 2026.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley   +1 more source

Development, Live Birth and Fertility in Mouse Oocytes Penetrated by Spermatids Exposed to the HDAC Inhibitor Scriptaid. [PDF]

Reprod Med Biol
Watanabe S, Takemoto Y, Inoue R, Tanaka I, Miyata H, Makino Y, Nagayoshi M, Nakajima D, Fujimoto S, Tanaka A.   +9 more
europepmc   +1 more source

Histone deacetylase (HDAC) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

FSP1 and histone deacetylases suppress cancer persister cell ferroptosis. [PDF]

Sci Adv
Higuchi M, Williams AF, Stuhlfire AE, Nguyen AH, Gervasio DAG, Turkal CE, Chon S, Hangauer MJ.   +7 more
europepmc   +1 more source

Importance of SUMOylation Consensus Sequence of MAFK in Regulating EMT, Tumor Growth, Stemness, and Drug Resistance

Cancer Science, Volume 117, Issue 2, Page 445-455, February 2026.
In this study, we focused on SUMOylation, a posttranslational modification, and investigated the importance of its consensus sequence in MAFK. We demonstrated that the non‐SUMOylation mimic mutant MAFK (EA) impairs MAFK‐induced EMT, cellular migration and invasion, tumor and sphere formation, acquisition of stem‐like properties, and drug resistance ...
Thuy Linh Dang Cao, Yukari Okita, Reon Yahatabara, Manar A. Elhinnawi, Nuriza Ulul Azmi, Thanasis Poullikkas, Hozumi Motohashi, Mitsuyasu Kato   +7 more
wiley   +1 more source

Discovery of novel itaconimide-based derivatives as potent HDAC inhibitors for the efficient treatment of prostate cancer

Qihe Jiang, Yu-Jiang Tang, Qing-lan Hu, Bichuan Wang, Xiu-Qin Ruan, Qingfa Zhou   +5 more
openalex   +1 more source

Trichostatin A Sensitizes Tumor Cells to Apoptosis Induced by Soluble Trimeric TRAIL‐Expressing Human Mesenchymal Stromal Cells

Cancer Science, Volume 117, Issue 2, Page 456-467, February 2026.
Human mesenchymal stromal cells (MSCs) were engineered to secrete an isoleucine‐zippered soluble trimeric TRAIL (SCZT) and evaluated with trichostatin A (TSA) to overcome TRAIL resistance. TSA upregulated DR5 and amplified caspase‐8–dependent apoptosis in vitro; in vivo, tumor‐homing MSCs combined with TSA suppressed the growth of both TRAIL‐sensitive ...
Ryosuke Uchibori, Ken Ohmine, Keiya Ozawa   +2 more
wiley   +1 more source

Inhibition of Histone Deacetylases Induces Cancer Cell Apoptosis Through the PERK Pathway of ER Stress Response. [PDF]

J Cell Mol Med
Wang X, Yang C, Yang Y, Xu F, Yuan D, Gu Y.   +5 more
europepmc   +1 more source

HDACs deacetylate histones

Reactome - a curated knowledgebase of biological pathways, 2014
openaire   +1 more source