Results 31 to 40 of about 116,207 (325)

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]

, 2008
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin, Batran, Salah-Eddin al-, Blaheta, Roman A., Hudak, Lukasz, Jonas, Dietger, Jüngel, Eva, Soldato, Piero Del, Sparatore, Anna, Wedel, Steffen Alexander   +8 more
core   +1 more source

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer [PDF]

, 2020
Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis.
Abu Nada, M, Ahmed, AA, Alajez, NM, Elkord, E, Kurer, MA, Murshed, K, Saleh, R, Sasidharan Nair, V, Taha, RZ, Toor, SM   +9 more
core   +3 more sources

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries [PDF]

, 2018
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and ...
Antonelli, Manila, Antonelli, Manila, Bailey, Simon, Bartels, Ute, Baugh, Joshua, Benesch, Martin, Biassoni, Veronica, Bison, Brigitte, Boddaert, Nathalie, Bouffet, Eric, Broniscer, Alberto, Broxson, Emmett, Calmon, Raphael, Castel, David, Chaney, Brooklyn, Chintagumpala, Murali, Colditz, Niclas, Comito, Melanie, Dholaria, Hetal, Doughman, Renee, Drissi, Rachid, Foreman, Nicholas K., Fouladi, Maryam, Fuller, Christine, Gerber, Nicolas U., Giagnacovo, Marzia, Gielen, Gerrit H., Giraud, G´eraldine, Goldman, Stewart, Gottardo, Nicholas, Grill, Jacques, Grotzer, Michael A., Hargrave, Darren, Hassall, Timothy, Hawkins, Cynthia, Hoffman, Lindsey M., Hoffmann, Marion, Hulleman, Esther, Jabado, Nada, Jadrijevic Cvrlje, Filip, Jones, Blaise, Jones, Chris, Jones, David T. W., Kaspers, Gertjan J. L., Khatua, Soumen, Kieran, Mark W., Kramm, Christof M., Lane, Adam, Leach, James, Leary, Sarah, Massimino, Maura, Miles, Lili, Minturn, Jane, Modena, Piergiorgio, Nazarian, Javad, Packer, Roger, Pfaff, Elke, Pfister, Stefan M., Pietsch, Torsten, Puget, Stephanie, Sanchez, Esther, Shih, Chie-Schin, Solanki, Guirish A., Sophie Carret, Anne, Sturm, Dominik, van Vuurden, Dannis G., Vandertop, William P., Varlet, Pascale, Veldhuijzen van Zanten, Sophie E. M., von Bueren, Andr´e O., Warmuth-Metz, Monika, Warren, Katherine E., Yanez Escorza, Nancy, Ziegler, David S.   +73 more
core   +7 more sources

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources

Ring size changes in the development of class I HDAC inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over
Er-Chieh Cho, Chi-Yuan Liu, Di-Wei Tang, Hsueh-Yun Lee   +3 more
doaj   +1 more source

Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors

Pharmaceuticals, 2022
Histone deacetylases (HDAC) are epigenetic enzymes responsible for repressing gene expression through the deacetylation of histone lysine residues. Therefore, inhibition of HDACs has become an interesting approach for the treatment of several diseases ...
Beatriz Silva Urias, Aline Renata Pavan, Gabriela Ribeiro Albuquerque, Igor Muccilo Prokopczyk, Tânia Mara Ferreira Alves, Thais Regina Ferreira de Melo, Geraldo Rodrigues Sartori, João Hermínio Martins da Silva, Chung Man Chin, Jean Leandro Dos Santos   +9 more
doaj   +1 more source

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types

OncoImmunology, 2018
Checkpoint inhibitors targeting the PD-1/PD-L1 axis are promising immunotherapies shown to elicit objective responses against multiple tumor types, yet these agents fail to benefit most patients with carcinomas.
Kristin C. Hicks, Massimo Fantini, Renee N. Donahue, Angie Schwab, Karin M. Knudson, Sarah R. Tritsch, Caroline Jochems, Paul E. Clavijo, Clint T. Allen, James W. Hodge, Kwong Y. Tsang, Jeffrey Schlom, Sofia R. Gameiro   +12 more
doaj   +1 more source

A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer. [PDF]

PLoS ONE, 2010
BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic strategy for advanced non-small cell lung cancer (NSCLC) is limitedly effective.
Yen-An Tang, Wei-Ling Wen, Jer-Wei Chang, Tzi-Tang Wei, Yi-Hung Carol Tan, Santosh Salunke, Chien-Tien Chen, Ching-Shih Chen, Yi-Ching Wang   +8 more
doaj   +1 more source

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]

, 2017
Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J, Barnes, Alexander B, Kyei, George B, Marshall, Garland R, Niu, Austin, Ramani, Rashmi, Ratner, Lee, Wender, Paul A, Williams, Robert M   +8 more
core   +2 more sources