Results 261 to 270 of about 81,753 (307)

HDAC inhibitors in HIV

Immunology & Cell Biology, 2011
Combination antiretroviral therapy (cART) has led to a very substantial reduction in morbidity and mortality in HIV‐infected patients; however, cART alone is unable to cure HIV and therapy is lifelong. Therefore, a new strategy to cure HIV is urgently needed.
Wightman, F, Ellenberg, P, Churchill, M, Lewin, SR   +3 more
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Paradigm shift of “classical” HDAC inhibitors to “hybrid” HDAC inhibitors in therapeutic interventions

European Journal of Medicinal Chemistry, 2021
'Epigenetic' regulation of genes via post-translational modulation of proteins is the current mainstay approach for the disease therapies, particularly explored in the Histone Deacetylase (HDAC) class of enzymes. Mainly sight saw in cancer chemotherapeutics, HDAC inhibitors have also found a promising role in other diseases (neurodegenerative disorders,
Gargi Nikhil, Vaidya, Pooja, Rana, Ashwini, Venkatesh, Deep Rohan, Chatterjee, Darshan, Contractor, Dinesh Parshuram, Satpute, Mithilesh, Nagpure, Alok, Jain, Dinesh, Kumar   +8 more
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Inside HDAC with HDAC inhibitors

European Journal of Medicinal Chemistry, 2010
Histone deacetylase inhibitors are a large group of diverse molecules intrinsically able to inhibit cell proliferation in various cancer cell lines. Their apoptotic effects have been linked to the modulation in the expression of several regulatory tumor suppressor genes caused by the modified status of histone acetylation, a key event in chromatin ...
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Teratogenic Activity of HDAC Inhibitors

Current Pharmaceutical Design, 2014
Modification of the terminal tails of histones is considered one of the documented mechanisms for epigenetic control of gene expression. Histone deacetylase inhibitors (HDACi) lead to a state of hyperacetylation of histone, a condition that can affect normal gene transcription.
E. Giavini, E. Menegola
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HDAC inhibitors block innate immunity

Blood, 2011
In this issue of Blood, Roger and colleagues present data on the magnitude of influence that broad-spectrum HDAC inhibitors exert on TLR-driven immune responses, thus demonstrating that HDAC inhibitors are immunosuppressive drugs.
Konrad A, Bode, Alexander H, Dalpke
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HDAC inhibitors in parasitic diseases

Immunology & Cell Biology, 2011
Parasitic diseases cause significant global morbidity and mortality, particularly in underdeveloped regions of the world. Malaria alone causes ∼800 000 deaths each year, with children and pregnant women being at highest risk. There is no licensed vaccine available for any human parasitic disease and drug resistance is compromising the efficacy of many ...
Andrews, Katherine T., Haque, Ashraful, Jones, Malcolm K.   +2 more
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Conformal prediction of HDAC inhibitors

SAR and QSAR in Environmental Research, 2019
The growing interest in epigenetic probes and drug discovery, as revealed by several epigenetic drugs in clinical use or in the lineup of the drug development pipeline, is boosting the generation of screening data. In order to maximize the use of structure-activity relationships there is a clear need to develop robust and accurate models to understand ...
U. Norinder, J.J. Naveja, E. López-López, D. Mucs, J.L. Medina-Franco   +4 more
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Histone deacetylase (HDACs) inhibitors: Clinical applications

2023
Histone Deacetylases (HDACs) deacetylate lysine residues in histone and non-histone proteins. HDACs have been implicated in several diseases, including cancer, neurodegeneration, and cardiovascular disease. HDACs play an essential role in gene transcription, cell survival, growth, and proliferation, with histone hypoacetylation as one of the critical ...
Kumar D, Shanmukha, Harikrishnareddy, Paluvai, Santosh K, Lomada, Mahesh, Gokara, Suresh K, Kalangi   +4 more
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HDAC Inhibitors and Chaperone Function

2012
Cellular chaperones promote the folding and maturation of newly synthesized proteins and partially folded proteins in the cytosol and endoplasmic reticulum (ER) as well as prevent the aggregation of misfolded proteins. Histone deacetylases (HDACs) and histone acetyl transferases catalyze the reversible acetylation of histones and nonhistone substrates ...
Rekha, Rao, Warren, Fiskus, Siddhartha, Ganguly, Suman, Kambhampati, Kapil N, Bhalla   +4 more
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ChemInform Abstract: Inside HDAC with HDAC Inhibitors

ChemInform, 2010
AbstractReview: 90 refs.
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