Results 271 to 280 of about 81,753 (307)

Novel HDAC Inhibitors with Radiosensitizing Properties

Radiation Research, 2005
The members of the histone deacetylase (HDAC) family play important roles in various cellular processes, including transcriptional regulation, cell proliferation, differentiation and apoptosis. Inhibitors of histone deacetylases are emerging as an important new class of chemotherapeutic agents.
Mira, Jung, Alfredo, Velena, Bin, Chen, Pavel A, Petukhov, Alan P, Kozikowski, Anatoly, Dritschilo   +5 more
openaire   +2 more sources

HDAC Inhibitors and Cancer Therapy

2010
Maintenance of normal cell growth and differentiation is highly dependent on coordinated and tight transcriptional regulation of genes. In cancer, genes encoding growth regulators are abnormally expressed. Particularly, silencing of tumor suppressor genes under the control of chromatin modifications is a major underlying cause of unregulated cellular ...
openaire   +2 more sources

Mechanisms of HDAC inhibitor-induced thrombocytopenia

European Journal of Pharmacology, 2007
Histone deacetylase inhibitors (HDAC inhibitors) are an emerging class of anticancer agents. To elucidate the mechanism of HDAC inhibitor-induced thrombocytopenia, we focused on the effects of HDAC inhibitors on megakaryocyte differentiation and performed Affymetrix GeneChip analysis of human megakaryocytic HEL cells treated with or without HDAC ...
Hideaki, Matsuoka, Akira, Unami, Takao, Fujimura, Takahisa, Noto, Yoko, Takata, Katsuhiko, Yoshizawa, Hiroaki, Mori, Ichiro, Aramori, Seitaro, Mutoh   +8 more
openaire   +2 more sources

Aspirin-inspired acetyl-donating HDACs inhibitors

Archives of Pharmacal Research, 2018
Aspirin is one of the oldest drugs for the treatment of inflammation, fever, and pain. It is reported to covalently modify COX-2 enzyme by acetylating a serine amino acid residue. By virtue of aspirin's acetylating potential, we for the first time developed novel acetyl-donating HDAC inhibitors. In this study, we report the design, synthesis, in silico
Jiah Lim, Yoojin Song, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee, Byoungduck Park, Young Ho Seo   +6 more
openaire   +2 more sources

HDAC Inhibitors

2006
Paul Kwon, Meier Hsu, Dalia Cohen, Peter Atadja   +3 more
openaire   +2 more sources

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

Ca-A Cancer Journal for Clinicians, 2022
Sharon Elad, Noam Yarom, Yehuda Zadik
exaly  

Trends in kinase drug discovery: targets, indications and inhibitor design

Nature Reviews Drug Discovery, 2021
Misty M Attwood, Stefan Knapp
exaly  

The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial

Nature Medicine, 2022
Adriaan A Voors, Christiane Angermann Angermann, John R Teerlink   +2 more
exaly  

HDACs Inhibitors

2010
Michael H. Bloch, Michael H. Bloch, Mark A. Geyer, David C. S. Roberts, Eileen M. Joyce, Jonathan P. Roiser, John H. Halpern, Joji Suzuki, Pedro E. Huertas, Torsten Passie, John H. Halpern, Joji Suzuki, Pedro E. Huertas, Torsten Passie, Joji Suzuki, Torsten Passie, Pedro E. Huertas, John H. Halpern, Joji Suzuki, Torsten Passie, Pedro E. Huertas, John H. Halpern, David E. Nichols, Marie-Louise G. Wadenberg, Trevor W. Robbins, David S. Baldwin, Sophie Tambour, John C. Crabbe, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Brian L. Odlaug, Jon E. Grant, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, Sarah Morgan, Angus Mackay, E. Ernst, Lawrence H. Price, Michael M. Morgan, MacDonald J. Christie, Susan Jones, Andrew Young, Elizabeth C. Warburton, Stephen J. Hill, Anthony R. Isles, Lawrence S. Wilkinson, Subhash C. Pandey, Subhash C. Pandey, Subhash C. Pandey, Aldo Badiani, James Winslow, Susan Jones, Jill B. Becker, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, David E. Nichols, Jason C. G. Halford, Stephen B. Dunnett, Martine Cador, Naheed (Max) Mirza, Andrea Bari, Yesne Alici, William Breitbart, Andrea Bari, Becky Kinkead, Charles B. Nemeroff, Lucy C. Guillory, Jason C. G. Halford, Ennio Esposito, William Invernizzi, Gary Remington, Tomasz Schneider, Michel Billiard, Michel Billiard, Alyson J. Bond, Paolo Nencini, Michele S. Milella, Brian E. Leonard, Yesne Alici, William Breitbart, Luis de Lecea, Michel Billiard, Samuel B. Hutton, Jason C. G. Halford, R. H. De Rijk, E. R. de Kloet, Tooru M. Mizuno, Maria Isabel Colado, A. Richard Green   +94 more
openaire   +1 more source

The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial

Nature Medicine, 2021
Barry A Borlaug, Dalane W Kitzman, Sanjiv J Shah   +2 more
exaly