Results 21 to 30 of about 8,808 (189)

A hierarchical indexing strategy for optimizing Apache Spark with HDFS to efficiently query big geospatial raster data

International Journal of Digital Earth, 2020
Earth observations and model simulations are generating big multidimensional array-based raster data. However, it is difficult to efficiently query these big raster data due to the inconsistency among the geospatial raster data model, distributed ...
Fei Hu, Chaowei Yang, Yongyao Jiang, Yun Li, Weiwei Song, Daniel Q. Duffy, John L. Schnase, Tsengdar Lee   +7 more
doaj   +1 more source

A distributed storage method of remote sensing data based on image blocks organization(一种基于影像块组织的遥感数据分布式存储方法)

Zhejiang Daxue xuebao. Lixue ban, 2014
云存储是解决动态增长的海量遥感数据产品存储管理难题的有效手段.针对云存储在遥感数据存储领域中存在的问题，提出了一种基于影像块组织的遥感数据分布式Key-Value存储模型，解决了分布式文件系统存储大规模影像块效率低下的问题，使遥感数据云存储具备了空间区域访问特性；结合开源分布式文件系统HDFS，实现了影像数据的分布式高效存储与空间区域检索.实验与分析表明，系统在多用户并发连接情况下可以维持较高的吞吐率，同时具备良好的可伸缩性和稳定性.
CHIZiwen(池子文), ZHANGFeng(张丰), DUZhenhong(杜震洪), LIURenyi(刘仁义)   +3 more
doaj   +1 more source

Dual-Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti-Inflammatory and Anti-Fibrotic Effects. [PDF]

Adv Sci (Weinh)
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Zhang H, Li J, Hua S, Wu S, He C, Zhu Y, Yin M, Zhou H, Liu H, Hasegawa C, Lyu J, Xiao K, Jiang H, Wang Y, Qian Y.   +14 more
europepmc   +2 more sources

Effect of MMP-2 gene silencing on radiation-induced DNA damage in human normal dermal fibroblasts and breast cancer cells

Genes and Environment, 2019
Introduction Diagnostic and therapeutic ionizing radiation (IR) is one of the well known long term risk factors of breast cancer. Extremely lethal consequences of IR causes double-strand breaks, which are mainly responsible for genomic instability ...
Gugalavath Shailender, Seema Kumari, Patnala Kiranmayi, Rama Rao Malla   +3 more
doaj   +1 more source

Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells

Frontiers in Cell and Developmental Biology, 2021
This study demonstrates, and confirms, that chromosome territory positioning is altered in primary senescent human dermal fibroblasts (HDFs). The chromosome territory positioning pattern is very similar to that found in HDFs made quiescent either by ...
Ishita S. Mehta, Ishita S. Mehta, Kumars Riyahi, Rita Torres Pereira, Karen J. Meaburn, Martin Figgitt, Martin Figgitt, Ian R. Kill, Christopher H. Eskiw, Joanna M. Bridger   +9 more
doaj   +1 more source

Gelam Honey Protects against Gamma-Irradiation Damage to Antioxidant Enzymes in Human Diploid Fibroblasts

Molecules, 2013
The present study was designed to determine the radioprotective effects of Malaysian Gelam honey on gene expression and enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) of human diploid fibroblasts (HDFs ...
Suzana Makpol, Tengku Ahbrizal Farizal Tengku Ahmad, Yasmin Anum Mohd Yusof, Nor Fadilah Rajab, Khairuddin Abdul Rahim, Zakiah Jubri   +5 more
doaj   +1 more source

Pharmacological Activation of Autophagy Restores Cellular Homeostasis in Ultraviolet-(B)-Induced Skin Photodamage

Frontiers in Oncology, 2021
Ultraviolet (UV) exposure to the skin causes photo-damage and acts as the primary etiological agent in photo-carcinogenesis. UV-B exposure induces cellular damage and is the major factor challenging skin homeostasis.
Sheikh Ahmad Umar, Sheikh Ahmad Umar, Naikoo Hussain Shahid, Naikoo Hussain Shahid, Lone Ahmad Nazir, Lone Ahmad Nazir, Malik Ahmad Tanveer, Malik Ahmad Tanveer, Gupta Divya, Gupta Divya, Sajida Archoo, Sajida Archoo, Sharma Rai Raghu, Sharma Rai Raghu, Sheikh Abdullah Tasduq, Sheikh Abdullah Tasduq   +15 more
doaj   +1 more source

Performance optimization for managing massive numbers of small files in distributed file systems [PDF]

, 2015
The processing of massive numbers of small files is a challenge in the design of distributed file systems. Currently, the combined-block-storage approach is prevalent. However, the approach employs the traditional file systems such as ExtFS and may cause
Fu, Songling, Liao, Xiangke, Huang, Chenlin, Li, Kenli, He, Ligang   +4 more
core   +1 more source

Deploying Apache Spark virtual clusters in cloud environments using orchestration technologies

Труды Института системного программирования РАН, 2018
Apache Spark is a framework providing fast computations on Big Data using MapReduce model. With cloud environments Big Data processing becomes more flexible since they allow to create virtual clusters on-demand. One of the most powerful open-source cloud
O. . Borisenko, R. . Pastukhov, S. . Kuznetsov   +2 more
doaj   +1 more source

Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway

Frontiers in Oncology, 2020
The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy.
Tingjian Zu, Tingjian Zu, Jie Wen, Jie Wen, Lin Xu, Lin Xu, Lin Xu, Hui Li, Jun Mi, Jun Mi, Hui Li, Cord Brakebusch, David E. Fisher, Xunwei Wu, Xunwei Wu, Xunwei Wu   +15 more
doaj   +1 more source