Results 21 to 30 of about 5,372 (204)

Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells

open access: yesFrontiers in Cell and Developmental Biology, 2021
This study demonstrates, and confirms, that chromosome territory positioning is altered in primary senescent human dermal fibroblasts (HDFs). The chromosome territory positioning pattern is very similar to that found in HDFs made quiescent either by ...
Ishita S. Mehta   +9 more
doaj   +1 more source

Gelam Honey Protects against Gamma-Irradiation Damage to Antioxidant Enzymes in Human Diploid Fibroblasts

open access: yesMolecules, 2013
The present study was designed to determine the radioprotective effects of Malaysian Gelam honey on gene expression and enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) of human diploid fibroblasts (HDFs ...
Suzana Makpol   +5 more
doaj   +1 more source

Pharmacological Activation of Autophagy Restores Cellular Homeostasis in Ultraviolet-(B)-Induced Skin Photodamage

open access: yesFrontiers in Oncology, 2021
Ultraviolet (UV) exposure to the skin causes photo-damage and acts as the primary etiological agent in photo-carcinogenesis. UV-B exposure induces cellular damage and is the major factor challenging skin homeostasis.
Sheikh Ahmad Umar   +15 more
doaj   +1 more source

Deploying Apache Spark virtual clusters in cloud environments using orchestration technologies

open access: yesТруды Института системного программирования РАН, 2018
Apache Spark is a framework providing fast computations on Big Data using MapReduce model. With cloud environments Big Data processing becomes more flexible since they allow to create virtual clusters on-demand. One of the most powerful open-source cloud
O. . Borisenko   +2 more
doaj   +1 more source

Cardiac and Vascular Remodeling After 6 Months of Therapy With Sacubitril/Valsartan: Mechanistic Insights From Advanced Echocardiographic Analysis

open access: yesFrontiers in Cardiovascular Medicine, 2022
BackgroundEffects of Sacubitril/Valsartan (S/V) on left ventricular (LV) mechanics and ventricular-arterial coupling in patients with heart failure with reduced ejection fraction (HFrEF) are not completely understood.
Sara Monosilio   +13 more
doaj   +1 more source

Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway

open access: yesFrontiers in Oncology, 2020
The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy.
Tingjian Zu   +15 more
doaj   +1 more source

Speciation‐Controlled C–F Bond Functionalization Enabled by Zwitterionic Pnictinidenes

open access: yesAngewandte Chemie, EarlyView.
Zwitterionic pnictinidenes turn C–F activation into C–X bond construction, enabling broad defluorinative functionalization of polyfluoro(hetero)arenes under mild conditions. Rather than following a metallomimetic Sb(I)/Sb(III) redox turnover, catalysis is redirected by ligand scrambling into a redox‐neutral manifold, revealing catalyst speciation as a ...
Irene Sánchez‐Sordo   +4 more
wiley   +2 more sources

Semantic web service-based messaging framework for prediction of fitness data using Hadoop distributed file system

open access: yesAutomatika, 2019
Big data is coined as word of mouth in this era due to the generation of huge volume of data every second from multiple sources like logs, web sources, and sensors, electrical and electronic devices.
R. Sethuraman, T Sasiprabha
doaj   +1 more source

Genome-Wide CRISPR Screen Identifies Host Factors Required by Toxoplasma gondii Infection

open access: yesFrontiers in Cellular and Infection Microbiology, 2020
Toxoplasma gondii are obligate intracellular protoza, and due to their small genome and limited encoded proteins, they have to exploit host factors for entry, replication, and dissemination.
Shui-Zhen Wu   +5 more
doaj   +1 more source

Ordinal Optimization-Based Performance Model Estimation Method for HDFS

open access: yesIEEE Access, 2020
Modeling and analyzing the performance of distributed file systems (DFSs) benefit the reliability and quality of data processing in data-intensive applications. Hadoop Distributed File System (HDFS) is a typical representative of DFSs.
Tian Ma, Feng Tian, Bo Dong
doaj   +1 more source

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