Results 1 to 10 of about 620 (69)

Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation

Current Issues in Molecular Biology
Tissue regeneration therapy based on human dental pulp cells (hDPCs) faces the distinct challenge of cellular senescence during massive expansion in vitro.
Shuhan Zhou
exaly   +3 more sources

The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA

Frontiers in Cell and Developmental Biology, 2023
Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies.
Paolo Pizzul, Carlo Rinaldi, Diego Bonetti   +2 more
doaj   +1 more source

Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations

Cells, 2023
The aim of the present study was to provide a comprehensive characterization of whole genome DNA methylation patterns in replicative and ionizing irradiation- or doxorubicin-induced premature senescence, exhaustively exploring epigenetic modifications in
Katarzyna Malgorzata Kwiatkowska, Eleni Mavrogonatou, Adamantia Papadopoulou, Claudia Sala, Luciano Calzari, Davide Gentilini, Maria Giulia Bacalini, Daniele Dall’Olio, Gastone Castellani, Francesco Ravaioli, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Dimitris Kletsas   +13 more
doaj   +1 more source

Sirtuins and chemokines as markers of replicative and induced senescence of human endotheliocytes

Acta Biomedica Scientifica, 2022
Background. One of the factors of the pathogenesis of atherosclerosis and other cardiovascular diseases is induced endothelial senescence. In this regard, the urgent task of molecular biology and medicine is the search for molecules that affect the ...
D. V. Savitskiy, N. S. Linkova, E. O. Kozhevnikova, K. L. Kozlov, E. M. Paltseva, T. V. Kvetnaia   +5 more
doaj   +1 more source

Fast assay to predict multipotent mesenchymal stromal cell replicative senescence dynamics

BioTechniques, 2022
The major obstacle to the application of mesenchymal stromal cells (MSCs) in regenerative medicine is the expansion of the donor-derived cells in vitro to obtain high cell numbers in the shortest possible time. However, MSCs gradually undergo replicative
Katja Kološa, Aleš Leskovšek, Teja Rajar, Tamara Lah   +3 more
doaj   +1 more source

Exogenous Hydrogen Sulfide Activates PI3K/Akt/eNOS Pathway to Improve Replicative Senescence in Human Umbilical Vein Endothelial Cells

Cardiology Research and Practice, 2023
Background. Endothelial cell senescence is one of the key mechanistic factors in the pathogenesis of atherosclerosis. In terms of molecules, the phosphatidylinositol 3-kinase/protein kinase B/endothelial nitric oxide synthase (PI3K/Akt/eNOS) signaling ...
Haiming Niu, Jianwei Li, Hongkai Liang, Guishen Wu, Miaolian Chen   +4 more
doaj   +1 more source

Biological and epigenetic alterations of mitochondria involved in cellular replicative and hydrogen peroxide-induced premature senescence of human embryonic lung fibroblasts

Ecotoxicology and Environmental Safety, 2021
The mitoepigenetic modifications may be closely related to cellular fate. Both the replicative and hydrogen peroxide (H2O2)-induced premature senescence models were used to detect the mitochondrial biological characteristics and the epigenetic factors ...
Yan Wang, Jianji Gao, Fan Wu, Caiyun Lai, Yueqi Li, Gaoqiang Zhang, Xinyue Peng, Susu Yu, Jiani Yang, Wei Wang, Wenjuan Zhang, Xingfen Yang   +11 more
doaj   +1 more source

Genome-Wide Methylation Changes Associated with Replicative Senescence and Differentiation in Endothelial and Bone Marrow Mesenchymal Stromal Cells

Cells, 2023
Bone marrow mesenchymal stromal cells (BMSCs) are multipotent cells able to self-renew and differentiate, depending on the microenvironment, into adipocytes and osteoblasts.
Angelica Giuliani, Maria Giulia Bacalini, Deborah Ramini, Emanuela Mensà, Chiara Giordani, Luciano Xumerle, Paolo Garagnani, Fabiola Olivieri, Antonio Domenico Procopio, Maria Rita Rippo, Jacopo Sabbatinelli   +10 more
doaj   +1 more source

Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases

Frontiers in Neuroscience, 2021
Senescent cells, which show the permanent growth arrest in response to various forms of stress, accumulate in the body with the progression of age, and are associated with aging and age-associated diseases.
Rezwana Ahmed, Rezwana Ahmed, Rezwana Ahmed, Yasukazu Nakahata, Yasukazu Nakahata, Kazuyuki Shinohara, Yasumasa Bessho   +6 more
doaj   +1 more source

Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells

Stem Cell Reports, 2020
Summary: Long-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence.
Eduardo Fernandez-Rebollo, Julia Franzen, Roman Goetzke, Jonathan Hollmann, Alina Ostrowska, Matteo Oliverio, Torsten Sieben, Björn Rath, Jan-Wilhelm Kornfeld, Wolfgang Wagner   +9 more
doaj   +1 more source