The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA [PDF]
Frontiers in Cell and Developmental Biology, 2023 Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies.
Paolo Pizzul +2 more
doaj +2 more sources
Exogenous Hydrogen Sulfide Activates PI3K/Akt/eNOS Pathway to Improve Replicative Senescence in Human Umbilical Vein Endothelial Cells [PDF]
Cardiology Research and Practice, 2023 Background. Endothelial cell senescence is one of the key mechanistic factors in the pathogenesis of atherosclerosis. In terms of molecules, the phosphatidylinositol 3-kinase/protein kinase B/endothelial nitric oxide synthase (PI3K/Akt/eNOS) signaling ...
Haiming Niu +4 more
doaj +2 more sources
Genome-Wide Methylation Changes Associated with Replicative Senescence and Differentiation in Endothelial and Bone Marrow Mesenchymal Stromal Cells [PDF]
Cells, 2023 Bone marrow mesenchymal stromal cells (BMSCs) are multipotent cells able to self-renew and differentiate, depending on the microenvironment, into adipocytes and osteoblasts.
Angelica Giuliani +10 more
doaj +2 more sources
CTCF Mediates Replicative Senescence Through POLD1. [PDF]
Front Cell Dev Biol, 2021 POLD1, the catalytic subunit of DNA polymerase δ, plays a critical role in DNA synthesis and DNA repair processes. Moreover, POLD1 is downregulated in replicative senescence to mediate aging. In any case, the components of age-related downregulation of POLD1 expression have not been fully explained.
Hou Y +8 more
europepmc +5 more sources
Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation [PDF]
Current Issues in Molecular BiologyTissue regeneration therapy based on human dental pulp cells (hDPCs) faces the distinct challenge of cellular senescence during massive expansion in vitro.
Shuhan Zhou, Jingyao Cui, Yu Shi
doaj +2 more sources
CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts. [PDF]
Oxid Med Cell Longev, 2022 Cellular senescence is characterized by cell cycle arrest and senescence‐associated secretory phenotypes. Cellular senescence can be caused by various stress stimuli such as DNA damage, oxidative stress, and telomere attrition and is related to several chronic diseases, including atherosclerosis, Alzheimer’s disease, and osteoarthritis.
Chen YH +4 more
europepmc +3 more sources
Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics [PDF]
Journal of NanobiotechnologyBackground Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials. In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal stem cells; however, it has been ...
Yingying Peng +6 more
doaj +2 more sources
Gene regulatory network analysis defines transcriptome landscape with alternative splicing of human umbilical vein endothelial cells during replicative senescence [PDF]
BMC Genomics, 2021 Background Endothelial cell senescence is the state of permanent cell cycle arrest and plays a critical role in the pathogenesis of age-related diseases.
Momoko Ohori +6 more
doaj +2 more sources
Cells, 2023 The aim of the present study was to provide a comprehensive characterization of whole genome DNA methylation patterns in replicative and ionizing irradiation- or doxorubicin-induced premature senescence, exhaustively exploring epigenetic modifications in
Katarzyna Malgorzata Kwiatkowska +13 more
doaj +1 more source
Replicative Senescence Revisited [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2002 Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested state are being discovered at a great pace.
Richard, Marcotte, Eugenia, Wang
openaire +2 more sources