The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA [PDF]
Frontiers in Cell and Developmental Biology, 2023 Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies.
Paolo Pizzul +2 more
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Exogenous Hydrogen Sulfide Activates PI3K/Akt/eNOS Pathway to Improve Replicative Senescence in Human Umbilical Vein Endothelial Cells [PDF]
Cardiology Research and Practice, 2023 Background. Endothelial cell senescence is one of the key mechanistic factors in the pathogenesis of atherosclerosis. In terms of molecules, the phosphatidylinositol 3-kinase/protein kinase B/endothelial nitric oxide synthase (PI3K/Akt/eNOS) signaling ...
Haiming Niu +4 more
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Genome-Wide Methylation Changes Associated with Replicative Senescence and Differentiation in Endothelial and Bone Marrow Mesenchymal Stromal Cells [PDF]
Cells, 2023 Bone marrow mesenchymal stromal cells (BMSCs) are multipotent cells able to self-renew and differentiate, depending on the microenvironment, into adipocytes and osteoblasts.
Angelica Giuliani +10 more
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Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells [PDF]
Nature CommunicationsIn the absence of telomerase, telomere shortening triggers replicative senescence, a tumor suppressor mechanism that is also associated with oncogenic genomic instability.
Prisca Berardi +15 more
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Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation [PDF]
Current Issues in Molecular BiologyTissue regeneration therapy based on human dental pulp cells (hDPCs) faces the distinct challenge of cellular senescence during massive expansion in vitro.
Shuhan Zhou, Jingyao Cui, Yu Shi
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Antioxidants, 2018 Selenoproteins are essential components of antioxidant defense, redox homeostasis, and cell signaling in mammals, where selenium is found in the form of a rare amino acid, selenocysteine.
Laurent Chavatte +2 more
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Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics [PDF]
Journal of NanobiotechnologyBackground Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials. In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal stem cells; however, it has been ...
Yingying Peng +6 more
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Cells, 2023 The aim of the present study was to provide a comprehensive characterization of whole genome DNA methylation patterns in replicative and ionizing irradiation- or doxorubicin-induced premature senescence, exhaustively exploring epigenetic modifications in
Katarzyna Malgorzata Kwiatkowska +13 more
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Sirtuins and chemokines as markers of replicative and induced senescence of human endotheliocytes
Acta Biomedica Scientifica, 2022 Background. One of the factors of the pathogenesis of atherosclerosis and other cardiovascular diseases is induced endothelial senescence. In this regard, the urgent task of molecular biology and medicine is the search for molecules that affect the ...
D. V. Savitskiy +5 more
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Fast assay to predict multipotent mesenchymal stromal cell replicative senescence dynamics
BioTechniques, 2022 The major obstacle to the application of mesenchymal stromal cells (MSCs) in regenerative medicine is the expansion of the donor-derived cells in vitro to obtain high cell numbers in the shortest possible time. However, MSCs gradually undergo replicative
Katja Kološa +3 more
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