Results 41 to 50 of about 59,366 (303)

Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells. [PDF]

PLoS ONE, 2018
BACKGROUND:Human adult adipose-derived stem cells (hADSCs) have become the most promising cell source for regenerative medicine. However the prolonged ex vivo expansion periods required to obtain the necessary therapeutic dose promotes progressive ...
Silvia García-López, Carmen Albo-Castellanos, Rocio G Urdinguio, Susana Cañón, Fátima Sánchez-Cabo, Alberto Martínez-Serrano, Mario F Fraga, Antonio Bernad   +7 more
doaj   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

The asymmetry of telomere replication contributes to replicative senescence heterogeneity [PDF]

Scientific Reports, 2015
AbstractIn eukaryotes, the absence of telomerase results in telomere shortening, eventually leading to replicative senescence, an arrested state that prevents further cell divisions. While replicative senescence is mainly controlled by telomere length, the heterogeneity of its onset is not well understood. This study proposes a mathematical model based
Bourgeron, Thibault, Xu, Zhou, Doumic, Marie, Teixeira, Maria Teresa   +3 more
openaire   +3 more sources

Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress

mSystems
Hydrogen peroxide (H2O2) is a typical representative substance of environmental oxidative stress. Exogenous substances can alter epigenetic modifications from the DNA to the RNA level through oxidative stress.
Chenyu Zhu, Tingting Huang, Jiaqi Fu, Min Li, Luyi Tan, Xinyu Zhang, Wenli Cheng, Caiyun Lai, Zhangying Wang, Wenji Zhang, Wenjuan Zhang   +10 more
doaj   +1 more source

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress [PDF]

, 1982
Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential.
A Carrel, A Comfort, A Götte, A Weismann, A Weismann, A Weismann, A Weismann, A Weismann, A Weismann, AH Ebeling, AJ Nienhaus, AL Muggleton-Harris, AO Martinez, AR Sheldrake, AR Williamson, B Charlesworth, B Hill, BL Strehler, C Darwin, C Zavala, CB Harley, CB Harley, CH Evans, CJ Epstein, CL Bunn, CM Child, CM Child, CS Minot, CW Daniel, D Harman, D Kram, D Lack, DA Ogden, DE Brash, E Bell, E Metchnikoff, E Stecker, EL Schneider, F Vogel, FM Burnet, GA Sacher, GC Williams, GH Stein, GJ Todaro, GM Martin, GM Martin, GM Martin, GM Martin, GM Martin, GP Bidder, GR Martin, HE Swim, HEM Kay, HJ Curtis, HR Hirsch, HW Woolhouse, I Zs-Nagy, J Bjorksten, J Maynard Smith, J Maynard Smith, J Ponten, J Smith-Sonneborn, JA Witkowski, JBS Haldane, JF Stanley, JR Smith, JR Smith, JR Smith, K Illmensee, K Kontermann, KH Rothfels, L Hayflick, L Hayflick, L Hayflick, L Szilard, LC Cole, LC Stevens, LE Orgel, LE Orgel, MR Rose, P Calow, PB Medawar, PB Medawar, PL Krohn, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Long De, R Pearl, R Rosenberger, RD Guthrie, RG Cutler, RG Cutler, RW Hart, S Linn, SH Vines, SJ Fulder, T Cremer, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, Thomas B. L. Kirkwood, Thomas Cremer, TM Sonneborn, TM Sonneborn, W Topp, WD Hamilton, ZhA Medvedev, ZhA Medvedev   +114 more
core   +1 more source

DNA damage-dependent mechanisms of ionizing radiation-induced cellular senescence [PDF]

PeerJ
Cellular senescence can be broadly categorized into replicative senescence and stress-induced premature senescence. Replicative senescence mainly results from the progressive shortening of telomeres during successive cell divisions, eventually leading to
Jiebing Guan, Tuo Li, Feifei Ma, Ning Wang, Huanteng Zhang, Jiale Li, Jianguo Li, Chang Xu, Qiang Liu   +8 more
doaj   +2 more sources

Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis

Cells, 2022
Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral infection induces acute pulmonary epithelial senescence followed by fibrosis ...
Xiaojing Hong, Lihui Wang, Kexiong Zhang, Jun Liu, Jun-Ping Liu   +4 more
doaj   +1 more source

Measuring vertebrate telomeres: applications and limitations [PDF]

, 2004
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic chromosomes that function in stabilizing chromosomal end integrity.
Allsopp RC, Barja G, Benetos A, Broccoli D, Chang E, Charnov E, Friedrich U, Gemmell NJ, Girondot M, Grant JD, Harley CB, IUCN, Jeanclos E, Kern S, Lambertsen RH, Meyne J, Miyashita N, Ogburn CE, Olsen E, Prowse KR, Rose MR, Slagboom PE, Stearns SC, Stearns SC, Turker M, Vaziri H, Watson J, Zeichner SL   +27 more
core   +1 more source

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Biological Research
BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation.
Shiva Marthandan, Uwe Menzel, Steffen Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter Hemmerich, Christoph Kaether, Stephan Diekmann   +8 more
doaj   +1 more source

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

PLoS Biology, 2007
Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments.
João F Passos, Gabriele Saretzki, Shaheda Ahmed, Glyn Nelson, Torsten Richter, Heiko Peters, Ilka Wappler, Matthew J Birket, Graham Harold, Karin Schaeuble, Mark A Birch-Machin, Thomas B L Kirkwood, Thomas von Zglinicki   +12 more
doaj   +1 more source