Results 41 to 50 of about 90,167 (92)

MicroRNA 299-3p modulates replicative senescence in endothelial cells

, 2013
MicroRNAs (miRNAs) regulate various cellular processes. While several genes associated with replicative senescence have been described in endothelial cells, miRNAs that regulate these genes remain largely unknown.
AbuBakar, Sazaly, Jong, Hui-Lan, Vanhoutte, P.M., Wong, PF, AbuBakar, S, Vanhoutte, PMGR, Jong, HL, Mustafa, MR, Wong, P.F., Mustafa, Mohd Rais   +9 more
core   +3 more sources

OCT4-driven PER1 activation promotes odontogenic differentiation in senescent SCAP spheres

International Journal of Oral Science
Mesenchymal stem cells (MSCs) hold significant promise for applications in regenerative medicine, yet their therapeutic potential is often limited by replicative senescence.
Changfang Li, Zibin Zhang, Zhuoxin Yang, Tingjie Liu, Xiaoning He, Bei Li, Wei Wang   +6 more
doaj   +1 more source

Effects of senolytic drugs on human mesenchymal stromal cells

Stem Cell Research & Therapy, 2018
Background Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effects of senolytic drugs have not been
Clara Grezella, Eduardo Fernandez-Rebollo, Julia Franzen, Mónica Sofia Ventura Ferreira, Fabian Beier, Wolfgang Wagner   +5 more
doaj   +1 more source

HDACs and the senescent phenotype of WI-38 cells

BMC Cell Biology, 2005
Background Normal cells possess a limited proliferative life span after which they enter a state of irreversible growth arrest. This process, known as replicative senescence, is accompanied by changes in gene expression that give rise to a variety of ...
Noonan Emily J, Place Robert F, Giardina Charles   +2 more
doaj   +1 more source

CSIG inhibits PTEN translation in replicative senescence

, 2008
Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) that was abundant in young human diploid fibroblast cells but declined upon replicative senescence.
Guo, Shuzhen, Li, Qian, Ma, Liwei, Zhang, Zongyu, Chang, Na, Wang, Wengong, Tong, Tanjun   +6 more
core   +1 more source

The Link Between Epigenetic Clocks for Aging and Senescence

Frontiers in Genetics, 2019
Replicative senescence of cells in vitro is often considered as counterpart for aging of the organism in vivo. In fact, both processes are associated with functional decay and similar molecular modifications.
Wolfgang Wagner, Wolfgang Wagner
doaj   +1 more source

Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach

Antioxidants, 2018
Selenoproteins are essential components of antioxidant defense, redox homeostasis, and cell signaling in mammals, where selenium is found in the form of a rare amino acid, selenocysteine.
Ghania Hammad, Yona Legrain, Zahia Touat-Hamici, Stéphane Duhieu, David Cornu, Anne-Laure Bulteau, Laurent Chavatte   +6 more
doaj   +1 more source

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

Frontiers in Genetics, 2020
Replicative senescence is a hallmark of aging, which also contributes to individual aging. Mouse embryonic fibroblasts (MEFs) provide a convenient replicative senescence model.
Wei Chen, Xuefei Wang, Gang Wei, Yin Huang, Yufang Shi, Yufang Shi, Dan Li, Shengnu Qiu, Bin Zhou, Junhong Cao, Meng Chen, Pengfei Qin, Wenfei Jin, Ting Ni   +13 more
doaj   +1 more source

Mathematical model linking telomeres to senescence in Saccharomyces cerevisiae reveals cell lineage versus population dynamics

Nature Communications
Telomere shortening ultimately causes replicative senescence. However, identifying the mechanisms driving replicative senescence in cell populations is challenging due to the heterogeneity of telomere lengths and the asynchrony of senescence onset. Here,
Anaïs Rat, Veronica Martinez Fernandez, Marie Doumic, Maria Teresa Teixeira, Zhou Xu   +4 more
doaj   +1 more source

Replicative senescence: a critical review.

, 2004
Human cells in culture have a limited proliferative capacity. After a period of vigorous proliferation, the rate of cell division declines and a number of changes occur in the cells including increases in size, in secondary lysosomes and residual bodies,
Cristofalo V. J., Allen R. G., LORENZINI, ANTONELLO, Tresini M., Torres C.   +4 more
core   +1 more source