Results 61 to 70 of about 59,366 (303)

Replicative senescence and arteriosclerosis after kidney transplantation

Nephrology Dialysis Transplantation, 2020
AbstractBackgroundReplicative senescence is associated with telomere shortening. In native kidneys, obtained prior to transplantation, we recently described and validated a significant association between shorter intrarenal telomere length and renal arteriosclerosis.
De Vusser, Katrien, Martens, Dries, Lerut, Evelyne, Kuypers, Dirk, Nawrot, Tim, Naesens, Maarten   +5 more
openaire   +5 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation in Saccharomyces cerevisiae

Communications Biology
Replicative senescence is triggered when telomeres reach critically short length and activate permanent DNA damage checkpoint-dependent cell cycle arrest.
Bechara Zeinoun, Maria Teresa Teixeira, Aurélia Barascu   +2 more
doaj   +1 more source

Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions?

The Scientific World Journal, 2002
No consensus exists so far on the definition of cellular senescence. The narrowest definition of senescence is irreversible growth arrest triggered by telomere shortening counting cell generations (definition 1). Other authors gave an enlarged functional
Olivier Toussaint, Patrick Dumont, Jose Remacle, Jean-Francois Dierick, Thierry Pascal, Christophe Frippiat, Joao Pedro Magalhaes, Stephanie Zdanov, Florence Chainiaux   +8 more
doaj   +1 more source

Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options [PDF]

Genetics and Molecular Biology
Senescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senescence. It can
Andrew Oliveira Silva, Thais Cardoso Bitencourt, Jose Eduardo Vargas, Lucas Rosa Fraga, Eduardo Filippi-Chiela   +4 more
doaj   +1 more source

Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]

, 2017
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D., Ahasan Al Tanim, K.M., Barber, Glen N., Berger, Shelley L., Capell, Brian C., Dou, Zhixun, Garcia, Benjamin A., Ghosh, Kanad, Jiang, Tianying, Kaestner, Klaus H., Kieckhaefer, Julia E., Lan, Yemin, Lin, Yanping, Millar, Sarah E., Sen, Payel, Seykora, John T., Shoshkes-Carmel, Michal, Simithy, Johayra, Vizioli, Maria Grazia, Wangensteen, Kirk J., Xu, Caiyue, Xu, Mingang, Zhou, Zhuo, Zhu, Jiajun   +23 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Single-cell RNA-seq analysis reveals the multi-step process of cellular senescence

Biochemistry and Biophysics Reports
Cellular senescence is a phenomenon marked by an irreversible growth arrest with altered physiological properties. Many studies have focused on the characteristics of cells that have already entered a senescent state. However, to elucidate the mechanisms
Minseo Ahn, Junil Kim, Jae Ho Seo
doaj   +1 more source

Isolation and Characterization of Ischemia-Derived Astrocytes (IDAs) with Ability to Transactivate Quiescent Astrocytes [PDF]

, 2016
Reactive gliosis involving activation and proliferation of astrocytes and microglia, is a widespread but largely complex and graded glial response to brain injury.
Barbeito, Osvaldo Luis, Cadena, María Vanesa, Dodes Traian, Martín Miguel, Murta, Verónica, Ramos, Alberto Javier, Rosciszewski, Gerardo Ariel, Setton, Clara Patricia, Usach, Vanina, Villarreal, Alejandro   +8 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source