Results 61 to 70 of about 90,167 (92)

Sequential changes of DNA methylation during replicative senescence.

, 2017
Sequential changes of DNA methylation during replicative senescence.
Yoshiro Kobayashi (3716794), Mizuho Sakaki (3716797), Kenichiro Hata (104281), Kohji Okamura (3555197), Yukiko Ebihara (2070271), Arisa Igarashi (471297), Kenji Matsumoto (48684), Kazuhiko Nakabayashi (28677), Kayoko Maehara (3716791)   +8 more
core   +1 more source

Deciphering the impact of TERT/telomerase on immunosenescence and T cell revitalization

Frontiers in Immunology
Immunosenescence impacts both the innate and adaptive immune systems, predominantly affecting certain immune cell types. A notable manifestation of immunosenescence is the diminished efficacy of adaptive immunity. The excessive senescence of immune cells,
Lingyi Huang, Mingfu Zhang, Ding Bai, Yi Qu   +3 more
doaj   +1 more source

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

Nature Communications, 2019
Senescence of metabolically active cells is a process linked to ageing. Here the authors reveal that CSB is required to block replicative senescence, and epigenetic control of CSB downregulation triggers proliferative arrest in a p21-dependent manner.
Clément Crochemore, Cristina Fernández-Molina, Benjamin Montagne, Audrey Salles, Miria Ricchetti   +4 more
doaj   +1 more source

Proteomics unveils novel common genes mediating both replicative and stress-induced senescence.

, 2015
Cellular senescence, a phenomenon correlated to both aging and age-related pathologies, as well as interfering with tumor progression, is closely associated with gene expression changes based on transcriptional, posttranscriptional and epigenetic ...
SUCCOIO, MARIANGELA, FARAONIO, RAFFAELLA, COMEGNA, Marika, D’Ambrosio, C, Scaloni, A, CIMINO, FILIBERTO   +5 more
core  

Conditional and replicative senescence in Escherichia coli

, 2006
Analysis of the molecular mechanisms underlying the cellular degeneration of bacteria in stationary phase (known as conditional senescence) reveals interesting similarities with the aging process of higher organisms.
Nyström, Thomas,, Fredriksson, Åsa,
core   +1 more source

The case for negative senescence [PDF]

Negative senescence is characterized by a decline in mortality with age after reproductive maturity, generally accompanied by an increase in fecundity. Hamilton (1966) ruled out negative senescence: we adumbrate the deficiencies of his model.
Deborah A. Roach, Martin Dölling, James W. Vaupel, Annette Baudisch, Jutta Gampe   +4 more
core  

Polymerase Epsilon Is Required To Maintain Replicative Senescence

Replicative senescence is a permanent cell cycle arrest in response to extensive telomere shortening. To understand the mechanisms behind a permanent arrest, we screened for factors affecting replicative senescence in budding yeast lacking telomere ...
Raykov V, Maringele L, Deshpande AM, Ivanova IG, Xue Y   +4 more
core   +5 more sources

p53 isoforms Delta 133p53 and p53 beta are endogenous regulators of replicative cellular senescence

, 2009
The finite proliferative potential of normal human cells leads to replicative cellular senescence, which is a critical barrier to tumour progression in vivo(1-3).
Harris, Curtis C., Ewy A. Mathe, Kumamoto, Kensuke, Bourdon, Jean-Christophe; id_orcid, Jane J. Sohn, Helen Ji, Mondal, Abdul M., Jean-Christophe Bourdon, Ji, Helen, Kensuke Kumamoto, Vojtesek, Borivoj, Elise D. Bowman, David P. Lane, Horikawa, Izumi, Fujita, Kaori, Borivoj Vojtesek, Izumi Horikawa, Schetter, Aaron J., Aaron J. Schetter, Giang H. Nguyen, Sharon R. Pine, Sohn, Jane J., Abdul M. Mondal, Lane, David P., Pine, Sharon R., Kaori Fujita, Curtis C. Harris, Nguyen, Giang H., Mathe, Ewy A., Bowman, Elise D.   +29 more
core   +1 more source

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21

Einstein (São Paulo)
Objective To follow the expansion of mesenchymal stem cells from umbilical cords by two classic senescence markers, p16 (INK4A) and p21 (CDKN1A), using practical, fast, and less expensive methods than the gold standard Western blotting technique, to ...
Aline da Silva, Carla de Azevedo Piccinato, Luiz Roberto Sardinha, Thiago Pinheiro Arrais Aloia, Anna Carla Goldberg   +4 more
doaj   +2 more sources

Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics

Journal of Nanobiotechnology
Background Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials. In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal stem cells; however, it has been ...
Yingying Peng, Tingting Zhao, Shuxuan Rong, Shuqing Yang, Wei Teng, Yunyi Xie, Yan Wang   +6 more
doaj   +1 more source