Results 81 to 90 of about 59,366 (303)

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. [PDF]

, 2016
Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however ...
Bhushan, Anil, Dhawan, Sangeeta, Dirice, Ercument, Kulkarni, Rohit N   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Link Between Epigenetic Clocks for Aging and Senescence

Frontiers in Genetics, 2019
Replicative senescence of cells in vitro is often considered as counterpart for aging of the organism in vivo. In fact, both processes are associated with functional decay and similar molecular modifications.
Wolfgang Wagner, Wolfgang Wagner
doaj   +1 more source

Modeling of Immunosenescence and Risk of Death from Respiratory Infections: Evaluation of the Role of Antigenic Load and Population Heterogeneity [PDF]

, 2017
It is well known that efficacy of immune functions declines with age. It results in an increase of severity and duration of respiratory infections and also in dramatic growth of risk of death due to these diseases after age 65.
Barbi, Elisabetta, Caselli, Graziella, Franceschi, C., Romanyukha, A. A., Sannikova, T. E., Yashin, A. I.   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

Frontiers in Genetics, 2020
Replicative senescence is a hallmark of aging, which also contributes to individual aging. Mouse embryonic fibroblasts (MEFs) provide a convenient replicative senescence model.
Wei Chen, Xuefei Wang, Gang Wei, Yin Huang, Yufang Shi, Yufang Shi, Dan Li, Shengnu Qiu, Bin Zhou, Junhong Cao, Meng Chen, Pengfei Qin, Wenfei Jin, Ting Ni   +13 more
doaj   +1 more source

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence. [PDF]

, 2020
There is a growing body of literature demonstrating the importance of T cell exhaustion in regulating and shaping immune responses to pathogens and cancer.
Canter, Robert J, Judge, Sean J, Murphy, William J   +2 more
core  

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. [PDF]

, 2015
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers ...
Ab Hamid, Hasiah, Abd Hamid, Roslida, Ahmed, Nuzhat, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Ali, Abdul Manaf, Amedei, Amedeo, Andrade-Vieira, Rafaela, Azqueta, Amaya, Baglole, Carolyn J., Barclay, Barry J., Bay, Sarah N., Berg, Arthur, Bisson, William H., Blanco-Aparicio, Carmen, Brooks, Samira A., Brown, Dustin G., Brunborg, Gunnar, Calaf, Gloria M., Carlin, Danielle J., Carnero, Amancio, Carpenter, David O., Casey, Stephanie C., Castellino, Robert C., Chapellier, Marion, Charles, Amelia K., Chen, Tao, Chen, Zhenbang, Cheng, Qiang (Shawn), Chiaradonna, Ferdinando, Christopher, Joseph A., Cohen-Solal, Karine A., Colacci, Annamaria, Collins, Andrew R., Corsini, Emanuela, Cruickshanks, Nichola, Curran, Colleen S., D'Abronzo, Leandro S., Darbre, Philippa, Darroudi, Firouz, de Cerain Salsamendi, Adela Lopez, Decker, William K., Dent, Paul, Di Fiore, Riccardo, Dong, Chenfang, Dormoy, Valerian, Dornetshuber-Fleiss, Rita, Eltom, Sakina, Engstrom, Wilhelm, Eriksson, Staffan, Felsher, Dean W., Fernando Martinez-Leal, Juan, Forte, Stefano, Ghosh, Paramita M., Gilbertson, Michael, Goldberg, Gary S., Gonzalez, Laetitia, Gonzalez, Michael J., Goodson, William H, Guarnieri, Tiziana, Gulliver, Linda, Harris, Shelley A., Heneberg, Petr, Hsu, Chia-Wen, Hsu, Hsue-Yin, Hu, Zhiwei, Hultman, Tove, III, Jian, Le, Karamouzis, Michalis V., Khatami, Mahin, Kirsch-Volders, Micheline, Klaunig, James E., Kleinstreuer, Nicole, Koch, Daniel C., Kondoh, Hiroshi, Koppen, Gudrun, Koturbash, Igor, Kravchenko, Julia, Krishnakumar, P. K., Krishnan, Harini, Kuemmerle, Nancy B., Laconi, Ezio, Laird, Dale W., Langie, Sabine A. S., Lasfar, Ahmed, Lee, Tae-Jin, Leung, Po Sing, Leyns, Luc, Li, Lin, Lin, Liang-Tzung, Lleonart, Matilde, Lowe, Leroy, Luanpitpong, Sudjit, Luqmani, Yunus, Lyerly, H. Kim, Maguer-Satta, Veronique, Manjili, Masoud H., Marignani, Paola A., Marongiu, Fabio, Martin, Francis L., Massfelder, Thierry, McCawley, Lisa J., Mehta, Rekha, Memeo, Lorenzo, Miousse, Isabelle R., Mondello, Chiara, Moon, Eun-Yi, Moorwood, Kim, Nahta, Rita, Nangami, Gladys, Nangia-Makker, Pratima, Narayanan, Kannan Badri, Naus, Christian C., Ochieng, Josiah, Odero-Marah, Valerie, Ogunkua, Olugbemiga, Olsen, Ann-Karin, Ostrosky-Wegman, Patricia, Otsuki, Takemi, Palorini, Roberta, Papagerakis, Silvana, Park, Hyun Ho, Pavanello, Sofia, Ponce-Cusi, Richard, Prudhomme, Kalan R., Raju, Jayadev, Rathmell, W. Kimryn, Ratovitski, Edward, Robey, R. Brooks, Rojanasakul, Yon, Rojas, Emilio, Roman, Jesse, Romano, Maria Fiammetta, Romano, Simona, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Ryeom, Sandra, Sabbisetti, Venkata, Salem, Hosni K., Salzberg, Anna C., Sanderson, Thomas, Scovassi, A. Ivana, Singh, Neetu, Sinha, Ranjeet K., Sone, Hideko, Soucek, Laura, Sun, Jun, Thompson, Patricia, Vaccari, Monica, Vadgama, Pankaj, Valverde, Mahara, van Larebeke, Nik, Van Schooten, Frederik J., Vento, Renza, Vermeulen, Louis, Vondracek, Jan, Wade, Mark, Wagemaker, Gerard, Ward, Andrew, Weisz, Judith, Whitfield, Jonathan R., Williams, Graeme, Williams, Marc A., Wise, John Pierce, Sr., Wise, Sandra S., Wolf, Gregory T., Woodrick, Jordan, Xia, Menghang, Yasaei, Hemad, Yedjou, Clement, Zhang, Luoping, Zhou, Binhua P.   +173 more
core   +11 more sources

Modeling of replicative senescence in hematopoietic development

Aging, 2009
Hematopoietic stem cells (HSC) give rise to an enormous number of blood cells throughout our life. In contrast their number of cell divisions preceding senescence is limited underin vitro culture conditions. Here we consider the question whether HSC can rejuvenate indefinitely or if the number of cell divisions is restricted.
Anna, Marciniak-Czochra, Thomas, Stiehl, Wolfgang, Wagner   +2 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source