Results 71 to 80 of about 90,167 (92)
Telomeres and telomerase in basal Metazoa
Invertebrate Survival Journal, 2017 Telomeres are protein-bound tandemly repeated simple DNA sequences placed at the chromosome ends, their role being essential for maintaining genome integrity.
I Udroiu +4 more
doaj
Senescence vs. sustenance: Evolutionary-demographic models of aging [PDF]
Humans, and many other species, suffer senescence: mortality increases and fertility declines with adult age. Some species, however, enjoy sustenance: mortality and fertility remain constant.
James W. Vaupel, Annette Baudisch
core
Intrinsic skin aging and replicative senescence represent fundamental biological processes underlying age-associated tissue dysfunction and pigmentation changes. Cellular senescence, characterized by permanent cell cycle arrest and metabolic alterations,
Hassan, Amina-Gharib
core +1 more source
Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence [PDF]
FEBS Letters, 2002 Exposure of human proliferative cells to subcytotoxic stress triggers stress-induced premature senescence (SIPS) which is characterized by many biomarkers of replicative senescence.
Marc Dieu +2 more
exaly +2 more sources
The many types of heterogeneity in replicative senescence
Yeast, 2019 International audienceReplicative senescence, which is induced by telomere shortening, underlies the loss of regeneration capacity of organs and is ultimately detrimental to the organism.
Zhou Xu, Maria Teresa Teixeira
exaly +2 more sources
Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2008 Replicative senescence of human fibroblasts in vitro has been used as a model for in vivo aging. The onset of replicative senescence varies between several months to years.
Ilko L Maier +2 more
exaly +2 more sources
FASEB Journal, 2005 Replicative senescence is thought to relate to aging in vivo and tumor suppression. In this report, we isolated a gene and designated it as RDL (replicative senescence down-regulated Leo1-like gene). RDL’s expression decreased upon replicative senescence
Zongyu Zhang, Tanjun Tong
exaly +2 more sources
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4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Molecular Cell, 2020Franck Pellestor +2 more
exaly