Results 51 to 60 of about 90,167 (92)

Biomarkers of replicative senescence revisited

, 2016
Biomarkers of replicative senescence can be defined as those ultrastructural and physiological variations as well as molecules whose changes in expression, activity or function correlate with aging, as a result of the gradual exhaustion of replicative ...
Nehlin, Jan
core   +1 more source

Senescence induction; a possible cancer therapy

Molecular Cancer, 2009
Cellular immortalization is a crucial step during the development of human cancer. Primary mammalian cells reach replicative exhaustion after several passages in vitro, a process called replicative senescence.
Kondoh Hiroshi, Artero-Castro Ana, LLeonart Matilde E   +2 more
doaj   +1 more source

Gene expression profiling of replicative and induced senescence

, 2015
Cellular senescence is a cell cycle arrest accompanied by high expression of cyclin dependent kinase inhibitors which counteract overactive growth signals, which serves as a tumor suppressive mechanism.
Adele Kruger (16638), Maggie Purcell (681273), Michael A Tainsky (681274)   +2 more
core   +1 more source

Differential gene expression in rodent embryo fibroblasts upon replicative senescence [PDF]

, 2002
Cancer arises as a consequence of the accumulation of multiple independent mutations in genes that regulate cell proliferation and survival. The acquisition of an unlimited proliferative potential is probably a critical step in this process since normal ...
Benvenuti, Silvia
core   +1 more source

Stable cellular senescence is associated with persistent DDR activation.

PLoS ONE, 2014
The DNA damage response (DDR) is activated upon DNA damage generation to promote DNA repair and inhibit cell cycle progression in the presence of a lesion.
Marzia Fumagalli, Francesca Rossiello, Chiara Mondello, Fabrizio d'Adda di Fagagna, Fabrizio d'Adda di Fagagna   +4 more
doaj   +1 more source

Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress

BMC Cancer, 2012
Background The finite replicative lifespan of cells, termed cellular senescence, has been proposed as a protective mechanism against the proliferation of oncogenically damaged cells, that fuel cancer. This concept is further supported by the induction of
Lafontaine Julie, Tchakarska Guergana, Rodier Francis, Mes-Masson Anne-Marie   +3 more
doaj   +1 more source

Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells

Nature Communications
In the absence of telomerase, telomere shortening triggers replicative senescence, a tumor suppressor mechanism that is also associated with oncogenic genomic instability.
Prisca Berardi, Veronica Martinez-Fernandez, Anaïs Rat, Fernando R. Rosas Bringas, Pascale Jolivet, Rachel Langston, Stefano Mattarocci, Alexandre Maes, Théo Aspert, Bechara Zeinoun, Karine Casier, Hinke G. Kazemier, Gilles Charvin, Marie Doumic, Michael Chang, Maria Teresa Teixeira   +15 more
doaj   +1 more source

RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia

BMC Genomics, 2019
Background Aging is affected by genetic and environmental factors, and cigarette smoking is strongly associated with accumulation of senescent cells.
Hannah Voic, Xiuying Li, Jun-Ho Jang, Chunbin Zou, Prithu Sundd, Jonathan Alder, Mauricio Rojas, Divay Chandra, Scott Randell, Rama K. Mallampalli, Yohannes Tesfaigzi, Tyrone Ryba, Toru Nyunoya   +12 more
doaj   +1 more source

Role of p16INK4A in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells

Biochemistry Research International, 2012
The p16INK4A (hereafter p16) tumor suppressor is encoded by the INK4A/ARF locus which is among the most commonly dysregulated sequences in human cancer. By inhibiting cyclin-dependent kinases, p16 activates the G1-S checkpoint, and this response is often
Razmik Mirzayans, Bonnie Andrais, Gavin Hansen, David Murray   +3 more
doaj   +1 more source

RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres

EMBO Reports
Telomere repeat-containing RNA (TERRA) is transcribed at telomeres and forms RNA–DNA hybrids. In budding yeast, the presence of RNA–DNA hybrids at short telomeres promotes homology-directed repair (HDR) and prevents accelerated replicative senescence ...
Fabio Bento, Matteo Longaretti, Vanessa Borges Pires, Arianna Lockhart, Brian Luke   +4 more
doaj   +1 more source