Results 31 to 40 of about 90,167 (92)

Secreted protein combination GAPDH/S100A8/S100A9 from human expanded potential stem cells counteracts mesenchymal stromal cell senescence

Stem Cell Research & Therapy
Background Human mesenchymal stromal cells (hMSCs) remain the most clinically advanced adult stem cell source; however, their therapeutic potential is limited by rapid replicative senescence during ex vivo expansion.
Qingcai Feng, Qianwen Pang, Hongyu Lu, Zijing Liu, Zhancheng Lin, Zhou Songyang, Feng Liu, Guang Shi   +7 more
doaj   +1 more source

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway

Stem Cell Research & Therapy, 2021
Background Expansion-mediated replicative senescence and age-related natural senescence have adverse effects on mesenchymal stem cell (MSC) regenerative capability and functionality, thus severely impairing the extensive applications of MSC-based ...
Chenchen Pi, Cao Ma, Huan Wang, Hui Sun, Xiao Yu, Xingyu Gao, Yue Yang, Yanan Sun, Haiying Zhang, Yingai Shi, Yan Li, Yulin Li, Xu He   +12 more
doaj   +1 more source

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis

Cells, 2022
It is widely accepted that senescent cells accumulate with aging. They are characterized by replicative arrest and the release of a myriad of factors commonly called the senescence-associated secretory phenotype. Despite the replicative cell cycle arrest,
Kay-Dietrich Wagner, Nicole Wagner
doaj   +1 more source

Microarray analysis of replicative senescence [PDF]

, 1999
Background: Limited replicative capacity is a defining characteristic of most normal human cells and culminates in senescence, an arrested state in which cells remain viable but display an altered pattern of gene and protein expression.
Chang, Edwin, Shelton, Dawne N., Dawne N. Shelton, Whittier, Peter S., Choi, Donghee, Donghee Choi, Peter S. Whittier, Edwin Chang, Walter D. Funk, Funk, Walter D.   +9 more
core   +1 more source

Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation in Saccharomyces cerevisiae

Communications Biology
Replicative senescence is triggered when telomeres reach critically short length and activate permanent DNA damage checkpoint-dependent cell cycle arrest.
Bechara Zeinoun, Maria Teresa Teixeira, Aurélia Barascu   +2 more
doaj   +1 more source

Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions?

The Scientific World Journal, 2002
No consensus exists so far on the definition of cellular senescence. The narrowest definition of senescence is irreversible growth arrest triggered by telomere shortening counting cell generations (definition 1). Other authors gave an enlarged functional
Olivier Toussaint, Patrick Dumont, Jose Remacle, Jean-Francois Dierick, Thierry Pascal, Christophe Frippiat, Joao Pedro Magalhaes, Stephanie Zdanov, Florence Chainiaux   +8 more
doaj   +1 more source

Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner. [PDF]

PLoS ONE, 2016
Recent evidence suggests that hydrogen sulfide (H2S) has cytoprotective and anti-aging effects. However, the mechanisms for such properties are not fully understood.
Reiko Sanokawa-Akakura, Shin Akakura, Siamak Tabibzadeh   +2 more
doaj   +1 more source

Single-cell RNA-seq analysis reveals the multi-step process of cellular senescence

Biochemistry and Biophysics Reports
Cellular senescence is a phenomenon marked by an irreversible growth arrest with altered physiological properties. Many studies have focused on the characteristics of cells that have already entered a senescent state. However, to elucidate the mechanisms
Minseo Ahn, Junil Kim, Jae Ho Seo
doaj   +1 more source

Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options [PDF]

Genetics and Molecular Biology
Senescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senescence. It can
Andrew Oliveira Silva, Thais Cardoso Bitencourt, Jose Eduardo Vargas, Lucas Rosa Fraga, Eduardo Filippi-Chiela   +4 more
doaj   +1 more source

The asymmetry of telomere replication contributes to replicative senescence heterogeneity [PDF]

, 2015
International audienceIn eukaryotes, the absence of telomerase results in telomere shortening, eventually leading to replicative senescence, an arrested state that prevents further cell divisions.
Doumic, Marie, Xu, Zhou, Bourgeron, Thibault, Teixeira, Maria Teresa   +3 more
core   +1 more source