Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform [PDF]
, 2012 Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.g., fluorescent imaging ...
Barral +25 more
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COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]
, 2020 COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx +30 more
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Frontiers in Cell and Developmental Biology, 2020 Retinal pigment epithelium (RPE) cellular senescence is an important etiology of age-related macular degeneration (AMD). Aging interventions based on the application of stem cells to delay cellular senescence have shown good prospects in the treatment of
Shoubi Wang +10 more
doaj +1 more source
Cellular senescence and aging: the role of B-MYB [PDF]
, 2014 Cellular senescence is a stable cell cycle arrest, caused by insults, such as: telomere erosion, oncogene activation, irradiation, DNA damage, oxidative stress, and viral infection.
Jat, PS, Lam, EW, Mowla, SN
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The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
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Bovine vitreous gel can reactivate replicative senescence of human dermal fibroblast
Indonesian Journal of Biotechnology, 2018 The most influential factor in the poor healing of chronic ulcers is replicative senescence of fibroblasts that are unresponsive to TGF-β1 stimulation.
Maria Vianny Sansan +3 more
doaj +1 more source
Cell Reports, 2015 The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress. Here, we show that the 5S RNP contributes to p53 activation and promotes cellular senescence in response to ...
Kazuho Nishimura +9 more
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Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs. [PDF]
PLoS ONE, 2014 In the last decades, cellular senescence is viewed as a complex mechanism involved in different processes, ranging from tumor suppression to induction of age-related degenerative alterations.
Marco Napolitano +7 more
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Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]
, 2018 BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina +6 more
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CSIG Inhibits PTEN Translation in Replicative Senescence [PDF]
Molecular and Cellular Biology, 2008 Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) that was abundant in young human diploid fibroblast cells but declined upon replicative senescence. Overexpression or knockdown of CSIG did not influence p21(Cip1) and p16(INK4a) expressions.
Liwei, Ma +6 more
openaire +2 more sources