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Replicative Senescence: An Old Lives' Tale? [PDF]
Cell, 1996 One might imagine that cellular senescence could inhibit tissue repair. However, substantial numbers of proliferative cells can often be recovered from very old tissues, and wounds do heal even in very old mammals (although sometimes more slowly). Of course, senescent cells may comprise only a small fraction of aged tissue. Indeed, in situ staining for
Judith Campisi
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Nature Communications, 2019 Senescence of metabolically active cells is a process linked to ageing. Here the authors reveal that CSB is required to block replicative senescence, and epigenetic control of CSB downregulation triggers proliferative arrest in a p21-dependent manner.
Clément Crochemore +4 more
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Sirtuins and chemokines as markers of replicative and induced senescence of human endotheliocytes
Acta Biomedica Scientifica, 2022 Background. One of the factors of the pathogenesis of atherosclerosis and other cardiovascular diseases is induced endothelial senescence. In this regard, the urgent task of molecular biology and medicine is the search for molecules that affect the ...
D. V. Savitskiy +5 more
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Fast assay to predict multipotent mesenchymal stromal cell replicative senescence dynamics
BioTechniques, 2022 The major obstacle to the application of mesenchymal stromal cells (MSCs) in regenerative medicine is the expansion of the donor-derived cells in vitro to obtain high cell numbers in the shortest possible time. However, MSCs gradually undergo replicative
Katja Kološa +3 more
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Enhanced Viral Replication by Cellular Replicative Senescence [PDF]
Immune Network, 2016 Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of influenza virus (IFV) and Varicella Zoster Virus (VZV) infection in senescent cells.
Kim, Ji-Ae +2 more
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The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
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Ecotoxicology and Environmental Safety, 2021 The mitoepigenetic modifications may be closely related to cellular fate. Both the replicative and hydrogen peroxide (H2O2)-induced premature senescence models were used to detect the mitochondrial biological characteristics and the epigenetic factors ...
Yan Wang +11 more
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Microarray analysis of replicative senescence [PDF]
Current Biology, 1999 Limited replicative capacity is a defining characteristic of most normal human cells and culminates in senescence, an arrested state in which cells remain viable but display an altered pattern of gene and protein expression. To survey widely the alterations in gene expression, we have developed a DNA microarray analysis system that contains genes ...
Shelton, Dawne N. +4 more
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Donor's age and replicative senescence favour the in-vitro mineralization potential of human fibroblasts [PDF]
, 2015 Aberrant mineralization of soft connective tissues (ectopic calcification) may occur as a frequent age-related complication. Still, it remains unclear the role of mesenchymal cell donor's age and of replicative senescence on ectopic calcification ...
Bartolomeo, Angelica +4 more
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Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]
, 2015 Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, Mark C +5 more
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