Results 11 to 20 of about 40,147 (254)
The many types of heterogeneity in replicative senescence [PDF]
Yeast, 2019 AbstractReplicative senescence, which is induced by telomere shortening, underlies the loss of regeneration capacity of organs and is ultimately detrimental to the organism. At the same time, it is required to protect organisms from unlimited cell proliferation that may arise from numerous stimuli or deregulations.
Zhou Xu, Maria TERESA Teixeira
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Replicative Senescence Revisited [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2002 Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested state are being discovered at a great pace.
Richard, Marcotte, Eugenia, Wang
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Microarray analysis of replicative senescence [PDF]
Current Biology, 1999 Limited replicative capacity is a defining characteristic of most normal human cells and culminates in senescence, an arrested state in which cells remain viable but display an altered pattern of gene and protein expression. To survey widely the alterations in gene expression, we have developed a DNA microarray analysis system that contains genes ...
Shelton, Dawne N. +4 more
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Ecotoxicology and Environmental Safety, 2021 The mitoepigenetic modifications may be closely related to cellular fate. Both the replicative and hydrogen peroxide (H2O2)-induced premature senescence models were used to detect the mitochondrial biological characteristics and the epigenetic factors ...
Yan Wang +11 more
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Enhanced Viral Replication by Cellular Replicative Senescence [PDF]
Immune Network, 2016 Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of influenza virus (IFV) and Varicella Zoster Virus (VZV) infection in senescent cells.
Kim, Ji-Ae +2 more
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Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
Frontiers in Neuroscience, 2021 Senescent cells, which show the permanent growth arrest in response to various forms of stress, accumulate in the body with the progression of age, and are associated with aging and age-associated diseases.
Rezwana Ahmed +6 more
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The asymmetry of telomere replication contributes to replicative senescence heterogeneity [PDF]
Scientific Reports, 2015 AbstractIn eukaryotes, the absence of telomerase results in telomere shortening, eventually leading to replicative senescence, an arrested state that prevents further cell divisions. While replicative senescence is mainly controlled by telomere length, the heterogeneity of its onset is not well understood. This study proposes a mathematical model based
Bourgeron, Thibault +3 more
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Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells
Stem Cell Reports, 2020 Summary: Long-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence.
Eduardo Fernandez-Rebollo +9 more
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Foods, 2023 Mesenchymal stem cells (MSCs) can be used as a cell source for cultivated meat production due to their adipose differentiation potential, but MSCs lose their stemness and undergo replicative senescence during expansion in vitro. Autophagy is an important
Lina Che +8 more
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BM-MSCs delay the senescence of naive CD8+T cells [PDF]
Jichu yixue yu linchuangObjective To verify the effect of bone marrow mesenchymal stem cells (BM-MSCs) in alleviating immune senescence, and to explore the main immune cell population improved by BM-MSCs.
GAO Jingxi, ZHAO Xiaoyan, ZHU Xingyu, SUN Zhao, HAN Qin, ZHAO Chunhua
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