Results 11 to 20 of about 90,167 (92)

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Biological Research
BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation.
Shiva Marthandan, Uwe Menzel, Steffen Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter Hemmerich, Christoph Kaether, Stephan Diekmann   +8 more
doaj   +2 more sources

A mechanistic investigation into candidate markers of telomere-induced senescence in normal human epidermal keratinocytes [PDF]

, 2014
PhDTelomere dysfunction is one mechanism of cellular and tissue ageing. Dysfunctional telomeres in fibroblasts are recognised as DNA double-strand breaks (DSBs) and trigger the DNA damage pathway of senescence.
dos Santos Soares Martins de Castro, Alicia Maria
core   +4 more sources

The effect of radiation on cellular ageing [PDF]

, 2012
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityHumans are exposed to low and moderate doses of ionising radiation (IR) from a range of diagnostic and occupational sources which may lead to cellular ...
Sabin, Rebecca Jane
core   +6 more sources

Senescence in vitro and ionising radiations—the human diploid fibroblast model [PDF]

, 1981
The influence of ionising radiations on ageing is still controversial. Since Hayflick established the concept that diploid cells have finite lifespan in vitro, human diploid fibroblast (HDF) cultures have been recognised as a potent experimental model ...
Cremer, Thomas, Stevenson, A. F. G.
core   +1 more source

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression [PDF]

, 2011
P>Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers ...
Marais, R., Marais, R, Bennett, DC, Julia K. Soo, Chow, J, Hill, L, Chow, J., Ross, ADM, W. Nicol Keith, MacKenzie Ross, A.D., Hossain, M., Bennett, D.C., Heung Chong, W, Hoare, S, Mehnaz Hossain, Soo, JK, Dorothy C. Bennett, Rebecca S. Collinson, Carla Milagre, Milagre, C., David M. Kallenberg, Lucy Hill, Collinson, RS, Mackenzie Ross, AD, Hill, L., Chong, WH, Richard Marais, Kallenberg, DM, Soo, J.K., Jade Chow, Keith, W.N., Hossain, M, Heung Chong, W., Hoare, S., Stacey Hoare, Kallenberg, D.M., Milagre, C, W. Heung Chong, Collinson, R.S., Keith, WN, Alastair D. MacKenzie Ross   +40 more
core   +1 more source

Ginsenoside Rg2 Promotes the Proliferation and Stemness Maintenance of Porcine Mesenchymal Stem Cells through Autophagy Induction

Foods, 2023
Mesenchymal stem cells (MSCs) can be used as a cell source for cultivated meat production due to their adipose differentiation potential, but MSCs lose their stemness and undergo replicative senescence during expansion in vitro. Autophagy is an important
Lina Che, Caixia Zhu, Lei Huang, Hui Xu, Xinmiao Ma, Xuegang Luo, Hongpeng He, Tongcun Zhang, Nan Wang   +8 more
doaj   +1 more source

BM-MSCs delay the senescence of naive CD8+T cells [PDF]

Jichu yixue yu linchuang
Objective To verify the effect of bone marrow mesenchymal stem cells (BM-MSCs) in alleviating immune senescence, and to explore the main immune cell population improved by BM-MSCs.
GAO Jingxi, ZHAO Xiaoyan, ZHU Xingyu, SUN Zhao, HAN Qin, ZHAO Chunhua
doaj   +1 more source

microRNA in cellular senescence [PDF]

, 2010
Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging.
Sedia, Carla
core   +1 more source

The Tocotrienol-Rich Fraction Is Superior to Tocopherol in Promoting Myogenic Differentiation in the Prevention of Replicative Senescence of Myoblasts. [PDF]

PLoS ONE, 2016
Aging results in a loss of muscle mass and strength. Myoblasts play an important role in maintaining muscle mass through regenerative processes, which are impaired during aging. Vitamin E potentially ameliorates age-related phenotypes.
Shy Cian Khor, Azraul Mumtazah Razak, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof, Norwahidah Abdul Karim, Suzana Makpol   +5 more
doaj   +1 more source

Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFβ and PI3K Pathways

Frontiers in Cell and Developmental Biology, 2020
Retinal pigment epithelium (RPE) cellular senescence is an important etiology of age-related macular degeneration (AMD). Aging interventions based on the application of stem cells to delay cellular senescence have shown good prospects in the treatment of
Shoubi Wang, Yurun Liu, Ying Liu, Chaoyang Li, Qi Wan, Liu Yang, Yaru Su, Yaqi Cheng, Chang Liu, Xiaoran Wang, Zhichong Wang   +10 more
doaj   +1 more source