Results 21 to 30 of about 59,366 (303)

Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases

Frontiers in Neuroscience, 2021
Senescent cells, which show the permanent growth arrest in response to various forms of stress, accumulate in the body with the progression of age, and are associated with aging and age-associated diseases.
Rezwana Ahmed, Rezwana Ahmed, Rezwana Ahmed, Yasukazu Nakahata, Yasukazu Nakahata, Kazuyuki Shinohara, Yasumasa Bessho   +6 more
doaj   +1 more source

Senescence in vitro and ionising radiations—the human diploid fibroblast model [PDF]

, 1981
The influence of ionising radiations on ageing is still controversial. Since Hayflick established the concept that diploid cells have finite lifespan in vitro, human diploid fibroblast (HDF) cultures have been recognised as a potent experimental model ...
A.F.G. Stevenson, Ban, Beer, Carrel, Cox, Cremer, Cristofalo, Ebeling, Finch, Fukushima, Guichard, Hayflick, Hayflick, Hayflick, Hoehn, Holliday, Holliday, Hopwood, Hug, Kaji, Kirkwood, Kirkwood, Laublin, Lima, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Maisin, Martin, Namba, Nicholas, Orgel, Orgel, Russ, Schneider, Schneider, Smith, Stevenson, T. Cremer, Walburg, Weismann, Williams, Wilson   +44 more
core   +1 more source

Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. [PDF]

, 2014
Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection.
Chou, Jennifer P, Effros, Rita B, Koduri, Megha P, Ramirez, Christina M, Ryba, Danielle M   +4 more
core   +2 more sources

Aging in vitro and D-glucose uptake kinetics of diploid human fibroblasts [PDF]

, 1981
By use of a rapid technique, initial rates of D-glucose transport were obtained during the lifespan in vitro of a commercially available strain of human embryo lung fibroblasts (Flow 2000).
Aizawa, Berumen, Blomquist, Bowman, Bramwell, Cremer, Cristofalo, Cristofalo, Germinario, Goldstein, Grinna, Harley, Haslam, Hayflick, Hayflick, Heldt, Hirschberg, Kaplan, Kelley, Klingenberg, Lowry, Martin, Martin, McKerrow, Plagemann, Plagemann, Polgar, Roberts, Rothstein, Schachtschabel, Schneider, Schneider, Schneider, Simons, Smith, Smith, Stevenson, Werdan, Zs.-Nagy   +38 more
core   +1 more source

Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells

Stem Cell Reports, 2020
Summary: Long-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence.
Eduardo Fernandez-Rebollo, Julia Franzen, Roman Goetzke, Jonathan Hollmann, Alina Ostrowska, Matteo Oliverio, Torsten Sieben, Björn Rath, Jan-Wilhelm Kornfeld, Wolfgang Wagner   +9 more
doaj   +1 more source

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]

, 2004
Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Bridger, JM, Kill, IR
core   +1 more source

Ginsenoside Rg2 Promotes the Proliferation and Stemness Maintenance of Porcine Mesenchymal Stem Cells through Autophagy Induction

Foods, 2023
Mesenchymal stem cells (MSCs) can be used as a cell source for cultivated meat production due to their adipose differentiation potential, but MSCs lose their stemness and undergo replicative senescence during expansion in vitro. Autophagy is an important
Lina Che, Caixia Zhu, Lei Huang, Hui Xu, Xinmiao Ma, Xuegang Luo, Hongpeng He, Tongcun Zhang, Nan Wang   +8 more
doaj   +1 more source

Cell aging preserves cellular immortality in the presence of lethal levels of damage. [PDF]

, 2019
Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells.
Chao, Lin, Proenca, Audrey Menegaz, Qiu, Andrew, Rang, Camilla Ulla, Shi, Chao   +4 more
core   +3 more sources

BM-MSCs delay the senescence of naive CD8+T cells [PDF]

Jichu yixue yu linchuang
Objective To verify the effect of bone marrow mesenchymal stem cells (BM-MSCs) in alleviating immune senescence, and to explore the main immune cell population improved by BM-MSCs.
GAO Jingxi, ZHAO Xiaoyan, ZHU Xingyu, SUN Zhao, HAN Qin, ZHAO Chunhua
doaj   +1 more source

The Tocotrienol-Rich Fraction Is Superior to Tocopherol in Promoting Myogenic Differentiation in the Prevention of Replicative Senescence of Myoblasts. [PDF]

PLoS ONE, 2016
Aging results in a loss of muscle mass and strength. Myoblasts play an important role in maintaining muscle mass through regenerative processes, which are impaired during aging. Vitamin E potentially ameliorates age-related phenotypes.
Shy Cian Khor, Azraul Mumtazah Razak, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof, Norwahidah Abdul Karim, Suzana Makpol   +5 more
doaj   +1 more source