Results 21 to 30 of about 40,147 (254)

The Tocotrienol-Rich Fraction Is Superior to Tocopherol in Promoting Myogenic Differentiation in the Prevention of Replicative Senescence of Myoblasts. [PDF]

PLoS ONE, 2016
Aging results in a loss of muscle mass and strength. Myoblasts play an important role in maintaining muscle mass through regenerative processes, which are impaired during aging. Vitamin E potentially ameliorates age-related phenotypes.
Shy Cian Khor, Azraul Mumtazah Razak, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof, Norwahidah Abdul Karim, Suzana Makpol   +5 more
doaj   +1 more source

Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFβ and PI3K Pathways

Frontiers in Cell and Developmental Biology, 2020
Retinal pigment epithelium (RPE) cellular senescence is an important etiology of age-related macular degeneration (AMD). Aging interventions based on the application of stem cells to delay cellular senescence have shown good prospects in the treatment of
Shoubi Wang, Yurun Liu, Ying Liu, Chaoyang Li, Qi Wan, Liu Yang, Yaru Su, Yaqi Cheng, Chang Liu, Xiaoran Wang, Zhichong Wang   +10 more
doaj   +1 more source

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

Cell Reports, 2015
The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress. Here, we show that the 5S RNP contributes to p53 activation and promotes cellular senescence in response to ...
Kazuho Nishimura, Takuya Kumazawa, Takao Kuroda, Naohiro Katagiri, Mai Tsuchiya, Natsuka Goto, Ryohei Furumai, Akiko Murayama, Junn Yanagisawa, Keiji Kimura   +9 more
doaj   +1 more source

Bovine vitreous gel can reactivate replicative senescence of human dermal fibroblast

Indonesian Journal of Biotechnology, 2018
The most influential factor in the poor healing of chronic ulcers is replicative senescence of fibroblasts that are unresponsive to TGF-β1 stimulation.
Maria Vianny Sansan, Sunardi Radiono, Muhamad Eko Irawanto, Yohanes Widodo Wirohadidjojo   +3 more
doaj   +1 more source

Adaptation in replicative senescence: a risky business [PDF]

Current Genetics, 2019
Cell proliferation is tightly regulated to avoid propagating DNA damage and mutations, which can lead to pathologies such as cancer. To ensure genome integrity, cells activate the DNA damage checkpoint in response to genotoxic lesions to block cell cycle progression.
Coutelier, Héloïse, Xu, Zhou
openaire   +3 more sources

Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress

mSystems
Hydrogen peroxide (H2O2) is a typical representative substance of environmental oxidative stress. Exogenous substances can alter epigenetic modifications from the DNA to the RNA level through oxidative stress.
Chenyu Zhu, Tingting Huang, Jiaqi Fu, Min Li, Luyi Tan, Xinyu Zhang, Wenli Cheng, Caiyun Lai, Zhangying Wang, Wenji Zhang, Wenjuan Zhang   +10 more
doaj   +1 more source

Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs. [PDF]

PLoS ONE, 2014
In the last decades, cellular senescence is viewed as a complex mechanism involved in different processes, ranging from tumor suppression to induction of age-related degenerative alterations.
Marco Napolitano, Marika Comegna, Mariangela Succoio, Eleonora Leggiero, Lucio Pastore, Raffaella Faraonio, Filiberto Cimino, Fabiana Passaro   +7 more
doaj   +1 more source

Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells. [PDF]

PLoS ONE, 2018
BACKGROUND:Human adult adipose-derived stem cells (hADSCs) have become the most promising cell source for regenerative medicine. However the prolonged ex vivo expansion periods required to obtain the necessary therapeutic dose promotes progressive ...
Silvia García-López, Carmen Albo-Castellanos, Rocio G Urdinguio, Susana Cañón, Fátima Sánchez-Cabo, Alberto Martínez-Serrano, Mario F Fraga, Antonio Bernad   +7 more
doaj   +1 more source

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Biological Research
BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation.
Shiva Marthandan, Uwe Menzel, Steffen Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter Hemmerich, Christoph Kaether, Stephan Diekmann   +8 more
doaj   +1 more source

DNA damage-dependent mechanisms of ionizing radiation-induced cellular senescence [PDF]

PeerJ
Cellular senescence can be broadly categorized into replicative senescence and stress-induced premature senescence. Replicative senescence mainly results from the progressive shortening of telomeres during successive cell divisions, eventually leading to
Jiebing Guan, Tuo Li, Feifei Ma, Ning Wang, Huanteng Zhang, Jiale Li, Jianguo Li, Chang Xu, Qiang Liu   +8 more
doaj   +2 more sources