Results 21 to 30 of about 90,167 (92)

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

Cell Reports, 2015
The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress. Here, we show that the 5S RNP contributes to p53 activation and promotes cellular senescence in response to ...
Kazuho Nishimura, Takuya Kumazawa, Takao Kuroda, Naohiro Katagiri, Mai Tsuchiya, Natsuka Goto, Ryohei Furumai, Akiko Murayama, Junn Yanagisawa, Keiji Kimura   +9 more
doaj   +1 more source

Bovine vitreous gel can reactivate replicative senescence of human dermal fibroblast

Indonesian Journal of Biotechnology, 2018
The most influential factor in the poor healing of chronic ulcers is replicative senescence of fibroblasts that are unresponsive to TGF-β1 stimulation.
Maria Vianny Sansan, Sunardi Radiono, Muhamad Eko Irawanto, Yohanes Widodo Wirohadidjojo   +3 more
doaj   +1 more source

Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress

mSystems
Hydrogen peroxide (H2O2) is a typical representative substance of environmental oxidative stress. Exogenous substances can alter epigenetic modifications from the DNA to the RNA level through oxidative stress.
Chenyu Zhu, Tingting Huang, Jiaqi Fu, Min Li, Luyi Tan, Xinyu Zhang, Wenli Cheng, Caiyun Lai, Zhangying Wang, Wenji Zhang, Wenjuan Zhang   +10 more
doaj   +1 more source

Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells [PDF]

, 2006
Tumor cells have the capacity to proliferate indefinitely that is qualified as replicative immortality. This ability contrasts with the intrinsic control of the number of cell divisions in human somatic tissues by a mechanism called replicative ...
CETIN-ATALAY, R, Yulug, I., Ozturk, Nuri, ARSLAN ERGÜL, AYÇA, MUMCUOGLU, M, Tez, M., Gur, Bala, AKCALI, KC, Ozturk, N., OZTURK, N, Mumcuoglu, M., OZTURK, M, GUR, B, Erdal, Esra, Gur, B., Arslan-Ergul, AYÇA, YAKICIER, C, Yulug, Isik, ERDAL, EBRU, Akcali, K. C., Cetin-Atalay, Rengul, Akcali, Kamil C., Yakicier, Cengiz, Cetin Atalay, R., YULUG, I, Mumcuoglu, Mine, Erdal, E., Senturk, S., YAGCI, T, ŞENTÜRK, ŞERİF, Ozturk, M., Ozturk, Mehmet, SENTURK, S, Arslan-Ergul, A., Yagci, Tamer, Yagci, T., YALCIN, O, Yalcin, O., Yalcin, Ozden, TEZ, M, Yakicier, C., Tez, Mesut   +41 more
core   +1 more source

Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs. [PDF]

PLoS ONE, 2014
In the last decades, cellular senescence is viewed as a complex mechanism involved in different processes, ranging from tumor suppression to induction of age-related degenerative alterations.
Marco Napolitano, Marika Comegna, Mariangela Succoio, Eleonora Leggiero, Lucio Pastore, Raffaella Faraonio, Filiberto Cimino, Fabiana Passaro   +7 more
doaj   +1 more source

Influence of Donor Age and Species Longevity on Replicative Cellular Senescence

, 2016
The replicative life span of cell strains obtained from multiple explants from the same individual is highly variable, additional variability is added when strains are obtained from different individuals.
LORENZINI, ANTONELLO, Maier, Andrea B., Andrea B. Maier, Antonello Lorenzini   +3 more
core   +1 more source

DNA damage-dependent mechanisms of ionizing radiation-induced cellular senescence [PDF]

PeerJ
Cellular senescence can be broadly categorized into replicative senescence and stress-induced premature senescence. Replicative senescence mainly results from the progressive shortening of telomeres during successive cell divisions, eventually leading to
Jiebing Guan, Tuo Li, Feifei Ma, Ning Wang, Huanteng Zhang, Jiale Li, Jianguo Li, Chang Xu, Qiang Liu   +8 more
doaj   +2 more sources

Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells. [PDF]

PLoS ONE, 2018
BACKGROUND:Human adult adipose-derived stem cells (hADSCs) have become the most promising cell source for regenerative medicine. However the prolonged ex vivo expansion periods required to obtain the necessary therapeutic dose promotes progressive ...
Silvia García-López, Carmen Albo-Castellanos, Rocio G Urdinguio, Susana Cañón, Fátima Sánchez-Cabo, Alberto Martínez-Serrano, Mario F Fraga, Antonio Bernad   +7 more
doaj   +1 more source

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

PLoS Biology, 2007
Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments.
João F Passos, Gabriele Saretzki, Shaheda Ahmed, Glyn Nelson, Torsten Richter, Heiko Peters, Ilka Wappler, Matthew J Birket, Graham Harold, Karin Schaeuble, Mark A Birch-Machin, Thomas B L Kirkwood, Thomas von Zglinicki   +12 more
doaj   +1 more source

Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis

Cells, 2022
Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral infection induces acute pulmonary epithelial senescence followed by fibrosis ...
Xiaojing Hong, Lihui Wang, Kexiong Zhang, Jun Liu, Jun-Ping Liu   +4 more
doaj   +1 more source