Results 1 to 10 of about 109,275 (186)
Puerarin blocks the aging phenotype in human dermal fibroblasts.
PLoS ONE, 2021 Dermal fibroblast aging contributes to aging-associated functional defects in the skin since dermal fibroblasts maintain skin homeostasis by interacting with the epidermis and extracellular matrix.
Yuki Kamiya +4 more
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The effect of aging in primary human dermal fibroblasts.
PLoS ONE, 2019 Skin aging is a complex process, and alterations in human skin due to aging have distinct characteristic as compared to other organs. The aging of dermal cells and the biological mechanisms involved in this process are key areas to understand skin aging.
Juliana Carvalhães Lago +1 more
doaj +3 more sources
Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging [PDF]
Journal of Investigative Dermatology, 2021 The aging process deleteriously alters the structure and function of dermal collagen. These alterations result in thinning, fragility, wrinkles, laxity, impaired wound healing, and a microenvironment conducive to cancer. However, the key factors responsible for these changes have not been fully elucidated, and relevant models for the study of skin ...
Taihao Quan +8 more
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Cosmetics, 2022 Aminocarbonyl proteins increase with age in the dermal layer. Gene Chip analysis of mRNA expression in human dermal fibroblasts cultured on collagen gels treated with glyceraldehyde as an aminocarbonyl protein and on untreated collagen gels showed a ...
Kazuhisa Maeda, Shiori Yoshida
doaj +1 more source
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]
, 2015 In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D +11 more
core +15 more sources
Pathogenesis of Photoaging in Human Dermal Fibroblasts
International Journal of Dermatology and Venerology, 2020 Ling-Yi Lee, Sheng-Xiu Liu
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Human dermal fibroblasts in psychiatry research [PDF]
Neuroscience, 2016 In order to decipher the disease etiology, progression and treatment of multifactorial human brain diseases we utilize a host of different experimental models. Recently, patient-derived human dermal fibroblast (HDF) cultures have re-emerged as promising in vitro functional system for examining various cellular, molecular, metabolic and (patho ...
S. Kálmán +3 more
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Cultured Human Dermal Fibroblasts do Produce Cortisol [PDF]
Journal of Investigative Dermatology, 2006 Known steroidogenic functions of the skin that are represented by the synthesis and metabolism of androgens and estrogens (Chen et al., 2002; Zouboulis and Degitz, 2004) probably include corticosteroids (Slominski et al., 2000; Slominski, 2005). Thus, the skin expresses both the genes and proteins involved in the synthesis of adrenal corticosteroids ...
Slominski, Andrzej +3 more
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JID Innovations, 2022 CCN2, a member of the CCN family of matricellular proteins, is a key mediator and biomarker of tissue fibrosis. We previously reported that CCN2 is significantly reduced in aged human dermis, which contributes to dermal aging through the downregulation ...
Zhaoping Qin +3 more
doaj +1 more source
Cells, 2021 The dermis is the connective layer between the epidermis and subcutis and harbours nerve endings, glands, blood vessels, and hair follicles. The most abundant cell type is the fibroblast.
Kimberly Nickel +4 more
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