Results 21 to 30 of about 109,393 (302)

Regulation of dermal fibroblasts by human neutrophil peptides

Scientific Reports, 2023
AbstractHuman neutrophil peptides (HNPs) can induce cell proliferation and activation so their growth promoting activities may have potential clinical benefit. This study investigated the effects of HNPs on human dermal fibroblasts. Differential gene expression in HNP-treated cells and genes involved in regulating intracellular pathways were explored ...
Nattarika Niwetbowornchai, Thanawat Chaisirirat, Sira Sriswasdi, Supichcha Saithong, Grace Filbertine, Helen L. Wright, Steven W. Edwards, Sita Virakul, Direkrit Chiewchengchol   +8 more
openaire   +3 more sources

Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. [PDF]

PLoS ONE, 2011
Previous studies demonstrated that protein kinase C- δ (PKC-δ) inhibition with the selective inhibitor, rottlerin, resulted in potent downregulation of type I collagen expression and production in normal human dermal fibroblasts and abrogated the ...
Peter J Wermuth, Sankar Addya, Sergio A Jimenez   +2 more
doaj   +1 more source

Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. [PDF]

, 2007
Despite several investigations, the transcriptional mechanisms that regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either physiological or pathological situations, such as scleroderma, are not completely known.
Beauchef, Gallic, Chadjichristos, Christos, Galéra, Philippe, Jimenez, Sergio A., Korn, Joseph, Kypriotou, Magdalini, Maquart, François-Xavier, Oddos, Thierry, Pujol, Jean-Pierre, Renard, Emmanuelle, Von Stetten, Otto, Widom, Russell   +11 more
core   +3 more sources

Hybrid bilayer PLA/chitosan nanofibrous scaffolds doped with ZnO, Fe3O4, and Au nanoparticles with bioactive properties for skin tissue engineering [PDF]

, 2020
Burns affect almost half a million of Americans annually. In the case of full-thickness skin injuries, treatment requires a transplant. The development of bioactive materials that promote damaged tissue regeneration constitutes a great alternative to ...
Bogdał, Dariusz, Janus, Łukasz, Matýsek, Dalibor, Piątkowski, Marek, Radwan-Pragłowska, Julia   +4 more
core   +1 more source

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair [PDF]

, 2011
Members of the galectin family of endogenous lectins are potent adhesion/growth-regulatory effectors. Their multi-functionality opens possibilities for their use in bioapplications. We studied whether human galectins induce the conversion of human dermal
André A., S., André K., S., Barbora Dvořánková, Bergmann J., M., Cheb Y.-Y., S.-J., Dam T.K., Demetter O., P., Dvoránková J., B., Engelhardt H.-J., R., Eva Sykova, Fischer H., C., Fritz A., P., Hans-Joachim Gabius, Herbert Kaltner, Hung C.W., Jana Uhrova, Jones D.L., Jones G.E., Jones G.E., Karel Smetana, Jr., Kim Y.-B., H.-W., Kojima S., S., Lacina H., L., Lacina J., L., Lataillade T., J.-J., Legendre N., H., Lensch A., M., Lu J., Z.-H., Lukas Lacina, Miller S.N., Nagy I., N., Nakachi Y., K., Nogales-Gonzalés A., A., O’Donoghue J., K., Pavol Szabo, Pei S., Z., Peter Gal, Sabine André, Sanchez-Ruderisch C., H., Sanchez-Ruderisch S., H., Sansone S., F., Seyrek H., K., Smetana B., K., Smetana L., K., Smetana Z., K., Tomas Zima, Uchida K., K., von Reitzenstein J., C.   +47 more
core   +1 more source

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. [PDF]

, 2017
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs. Protein tyrosine phosphatases have received little attention in the study of SSc or fibrosis.
Bai, Yunpeng, Boin, Francesco, Bottini, Nunzio, Ceponis, Arnold, Chernitskiy, Vladimir, Cipriani, Paola, Di Benedetto, Paola, Giacomelli, Roberto, Jimenez, Sergio A, Kaestner, Klaus H, Kiosses, William B, Piera-Velazquez, Sonsoles, Sacchetti, Cristiano, Santelli, Eugenio, Stanford, Stephanie M, Zhang, Zhong-Yin   +15 more
core   +2 more sources

Human fetal dermal fibroblast-myeloid cell diversity is characterized by dominance of pro-healing Annexin1-FPR1 signaling

iScience, 2023
Summary: Fetal skin achieves scarless wound repair. Dermal fibroblasts play a central role in extracellular matrix deposition and scarring outcomes. Both fetal and gingival wound repair share minimal scarring outcomes.
Rajneesh Srivastava, Kanhaiya Singh, Ahmed S. Abouhashem, Manishekhar Kumar, Sedat Kacar, Sumit S. Verma, Sujit K. Mohanty, Mithun Sinha, Subhadip Ghatak, Yi Xuan, Chandan K. Sen   +10 more
doaj   +1 more source

Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. [PDF]

, 2008
OBJECTIVE: Recent studies have implicated caveolin 1 in the regulation of transforming growth factor beta (TGFbeta) downstream signaling. Given the crucial role of TGFbeta in the pathogenesis of systemic sclerosis (SSc), we sought to determine whether ...
de Almeida, Cecilia J., Del Galdo, Francesco, Jasmin, Jean-Francois, Jimenez, Sergio A., Lisanti, Michael P., Musick, Megan, Sotgia, Federica   +6 more
core   +2 more sources

α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts

Molecules, 2019
Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced ...
Tao Tong, Jinju Park, Youna Moon, Wesuk Kang, Taesun Park   +4 more
doaj   +1 more source

Influence of Human Dermal Fibroblasts on Epidermalization

Journal of Investigative Dermatology, 1989
Using a method that allowed the reconstruction of simplified living human skin in vitro, we investigated the effects of collagen texture and dermal fibroblasts on epidermal growth. Like in vivo skin, our in vitro model comprised two tissues: a dermal equivalent and an overlying epidermis.
Coulomb, Bernard, Lebreton, Corinne, Dubertret, Louis   +2 more
openaire   +2 more sources