Results 31 to 40 of about 109,393 (302)

Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence

Genes, 2022
Researchers are paying more and more attention to aging, especially skin aging. Therefore, it is urgent to find an effective way to inhibit aging. Here, we report a small chemical molecule, HCP1, that inhibited the senescence of human dermal fibroblasts (HDFs). First, we performed morphological experiment and found that HCP1-treated HDFs were no longer
Xiaoling Cui, Xuxiao Hao, Jie Wen, Shangli Zhang, Baoxiang Zhao, Junying Miao   +5 more
openaire   +2 more sources

β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts

Biomolecules, 2021
Stress is a major contributing factor of skin aging, which is clinically characterized by wrinkles, loss of elasticity, and dryness. In particular, glucocorticoids are generally considered key hormones for promoting stress-induced skin aging through ...
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park   +4 more
doaj   +1 more source

The connexin mimetic peptide Gap27 and Cx43-Knockdown reveal differential roles for Connexin43 in wound closure events in skin model systems [PDF]

, 2018
In the epidermis, remodelling of Connexin43 is a key event in wound closure. However, controversy between the role of connexin channel and non-channel functions exist.
Annette Graham, Chrysovalantou Faniku, Claire Lorraine, Erin O’Shaughnessy, Oviedo-Orta, Patricia Martin, Scott R. Johnstone, Sebastian Greenhough   +7 more
core   +4 more sources

The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts. [PDF]

PLoS ONE, 2016
We recently reported that the over-expression of skin fibroblast-derived neutral endopeptidase (NEP) plays a pivotal role in impairing the three-dimensional architecture of dermal elastic fibers during the biological mechanism of ultraviolet (UV)-induced
Hiroaki Nakajima, Shuko Terazawa, Takao Niwano, Yorihiro Yamamoto, Genji Imokawa   +4 more
doaj   +1 more source

Skin grafts : local quest for viable alternatives to autologous grafts using silk and acellular dermal matrices [PDF]

, 2014
The gold standard with regards to skin transplantation is the use of the patient’s own skin obtained from a healthy donor site. Such grafts can be either full thickness skin or more commonly nowadays, split thickness skin.
Gialanzè, Yanika, Schembri-Wismayer, Pierre, Xuereb, Angela A.   +2 more
core   +1 more source

Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing. [PDF]

, 2020
Platelets are a recognised potent source of transforming growth factor-β1 (TGFβ1), a cytokine known to promote wound healing and regeneration by stimulating dermal fibroblast proliferation and extracellular matrix deposition.
Chong, DLW, Holmes, AM, Hughes, S, Labelle, M, Porter, JC, Rodriguez-Justo, M, Scotton, CJ, Trinder, S   +7 more
core   +3 more sources

Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts. [PDF]

PLoS ONE, 2017
Ageing, the progressive functional decline of virtually all tissues, affects numerous living organisms. Main phenotypic alterations of human skin during the ageing process include reduced skin thickness and elasticity which are related to extracellular ...
Wolfgang Kaisers, Petra Boukamp, Hans-Jürgen Stark, Holger Schwender, Julia Tigges, Jean Krutmann, Heiner Schaal   +6 more
doaj   +1 more source

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke [PDF]

, 2013
Haemorrhagic stroke accounts for approximately 20% of stroke cases and porencephaly is a clinical consequence of perinatal cerebral haemorrhaging. Here we report the identification of a novel dominant G702D mutation in the collagen domain of COL4A2 ...
Aislynn Taggart, Bateman, Brazel, Catheline Vilain, de Clerck, Engin, Favor, Geesin, Gould, Gould, Gould, Hostikka, Ishida, Jeanne, Kalluri, Karl E. Kadler, Khoshnoodi, Lydia S. Murray, Marc Abramowicz, Muthukumaran, Nicole Van Regemorter, Ozcan, Plaisier, Plaisier, Poschl, Ron, Taylor, Tom Van Agtmael, Vahedi, Van Agtmael, Van Agtmael, Van Agtmael, Verbeek, Vilain, Woo, Yinhui Lu   +35 more
core   +1 more source

Inonotus obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

Cosmetics, 2020
Inonotus obliquus, which is parasitic on birch and other trees, is a fungus in the family Hymenochaetaceae. In this study, we investigated whether Inonotus obliquus extracts used in traditional medicine were decreased in the expression of matrix ...
Young Joo Kim, Hwa Jun Cha
doaj   +1 more source

Biocompatibility and tissue regenerating capacity of crosslinked dermal sheep collagen [PDF]

, 1994
The biocompatibility and tissue regenerating capacity of four crosslinked dermal sheep collagens (DSC) was studied. In vitro, the four DSC versions were found to be noncytotoxic or very low in cytoxicity.
Anselme, Bannenberg, Berry, Bessis, Blaauw, Damink, Damink, Damink, Damink, Damink, Damink, Damink, Flory, Galli, Gorham, Levy, Nedkov, Petite, Schoen, Speer, Srivastava, Steinberg, van der Laan, van der Wal, van Gulik, van Luyn, van Luyn, van Luyn, van Luyn, van Luyn, van Wachem, van Wachem, van Wachem, van Wachem, Wasserman, Weiss, Werkmeister   +36 more
core   +2 more sources