Results 31 to 40 of about 7,662,162 (290)

Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing

Scientific Reports, 2021
Inspired by the effectiveness of low-intensity ultrasound on tissue regeneration, we investigated the potential effect of short-term high-intensity ultrasound treatment for acceleration of wound healing in an in vitro wound model and dermal equivalent ...
Jeong Yu Lee, Dae-Jin Min, Wanil Kim, Bum-Ho Bin, Kyuhan Kim, Eun-Gyung Cho   +5 more
doaj   +1 more source

Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins.

PLoS ONE, 2015
In stem cell cultures from adult human tissue, undesirable contamination with fibroblasts is frequently present. The presence of fibroblasts obscures the actual number of stem cells and may result in extracellular matrix production after transplantation.
C J Janmaat, K E de Rooij, H Locher, S C de Groot, J C M J de Groot, J H M Frijns, M A Huisman   +6 more
doaj   +1 more source

Discrepant Activation Pattern of Inflammation and Pyroptosis Induced in Dermal Fibroblasts in Response to Dengue Virus Serotypes 1 and 2 and Nonstructural Protein 1

Microbiology Spectrum, 2023
Four serotypes of dengue virus (DENV-1 to DENV-4) cause mild to severe disease in humans through infected mosquito bites. Dermal fibroblasts were found to be susceptible to DENV, and this may play a critical role in establishing the initial infection ...
Kai-Che Wei, Wan-Ju Wei, Ching-Len Liao, Tsung-Hsien Chang   +3 more
doaj   +1 more source

Human Dermal Fibroblasts Synthesize Laminin

Journal of Investigative Dermatology, 1988
Laminin, a glycoprotein of approximately 900,000 daltons, is a major component of the basement membrane that separates the epidermis from dermis in human skin. Previous studies have shown that keratinocytes and other epithelial cells synthesize laminin and utilize it for attachment to other extracellular matrices such as heparan sulfate proteoglycan ...
Woodley, David T., Stanley, John R., Reese, Melinda J., O'keefe, Edward J.   +3 more
openaire   +2 more sources

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts [PDF]

, 2009
Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix ...
Christopher P Denton, Abraham, DJ, Denton, CP, Mark Eastwood, Sonali Sonnylal, Shi-Wen, X., Liu Shangxi, Leask, A., Abraham David J., Liu, SX, Shi-wen, X, Denton, C.P., Shangxi Liu, Sonnylal, S, Abraham, D.J., David J Abraham, Liu, S., Andrew Leask, Shi-wen Xu, Denton Christopher P., Eastwood Mark, Eastwood, M, Leask, A, Eastwood, M., Sonnylal Sonali, Leask Andrew, Sonnylal, S.   +26 more
core   +2 more sources

Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. [PDF]

PLoS ONE, 2011
Previous studies demonstrated that protein kinase C- δ (PKC-δ) inhibition with the selective inhibitor, rottlerin, resulted in potent downregulation of type I collagen expression and production in normal human dermal fibroblasts and abrogated the ...
Peter J Wermuth, Sankar Addya, Sergio A Jimenez   +2 more
doaj   +1 more source

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts [PDF]

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +2 more sources

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M.   +10 more
core   +2 more sources

α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts

Molecules, 2019
Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced ...
Tao Tong, Jinju Park, Youna Moon, Wesuk Kang, Taesun Park   +4 more
doaj   +1 more source

Human fetal dermal fibroblast-myeloid cell diversity is characterized by dominance of pro-healing Annexin1-FPR1 signaling

iScience, 2023
Summary: Fetal skin achieves scarless wound repair. Dermal fibroblasts play a central role in extracellular matrix deposition and scarring outcomes. Both fetal and gingival wound repair share minimal scarring outcomes.
Rajneesh Srivastava, Kanhaiya Singh, Ahmed S. Abouhashem, Manishekhar Kumar, Sedat Kacar, Sumit S. Verma, Sujit K. Mohanty, Mithun Sinha, Subhadip Ghatak, Yi Xuan, Chandan K. Sen   +10 more
doaj   +1 more source