Results 51 to 60 of about 60,877 (261)

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Implantable Ionic Memristors Based on Natural Polymer Heterojunctions

Advanced Functional Materials, EarlyView.
We report an implantable natural polymer‐based ionic memristor composed of hyaluronic acid, chitosan, and PDMS. The device achieved 98.94% accuracy in MNIST classification while reducing training time by 36.8% compared with a conventional artificial neural network (ANN).
Dong‐yup Lee, Byung Ik Park, Gihyeon Yim, Hyunjae Yoo, Sangjun Ma, Jundong Park, Jeong‐Yun Sun   +6 more
wiley   +1 more source

The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity

EMBO Reports
The heterogeneity of dermal mesenchymal cells, including perivascular mesenchymal cells and papillary and reticular fibroblasts, plays critical roles in skin homeostasis.
Shun Kimura, Sachiko Sekiya, Sawa Yamashiro, Tetsutaro Kikuchi, Masatoshi Haga, Tatsuya Shimizu   +5 more
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

IFN-Dependent and -Independent Reduction in West Nile Virus Infectivity in Human Dermal Fibroblasts

Viruses, 2014
Although dermal fibroblasts are one of the first cell types exposed to West Nile virus (WNV) during a blood meal by an infected mosquito, little is known about WNV replication within this cell type.
Lisa I. Hoover, Brenda L. Fredericksen
doaj   +1 more source

Activation of the JNKs/ATM-p53 axis is indispensable for the cytoprotection of dermal fibroblasts exposed to UVB radiation

Cell Death and Disease, 2022
Although UVB radiation is mainly absorbed by the epidermis, ~5–10% of its photons reach and affect the upper part of the dermis. Physiologically relevant UVB doses, able to provoke erythema, induce apoptosis in human dermal fibroblasts in vitro, as well ...
Eleni Mavrogonatou, Maria Angelopoulou, Sophia V. Rizou, Harris Pratsinis, Vassilis G. Gorgoulis, Dimitris Kletsas   +5 more
doaj   +1 more source

Human Dermal Fibroblast Cells Express Prolactin In Vitro

Journal of Investigative Dermatology, 1996
This study demonstrates the synthesis and release of prolactin (PRL) from dermal fibroblasts (>98%) in vitro, suggesting a potential local source of PRL in skin. PRL release was first detected in confluent cultures (0.25 x 10(6) plated cells) on or before day 18 and increased to a maximal level of 2 ng/72 h by day 30.
Richards, Randall G., Hartman, Scott M.
openaire   +2 more sources

Mechanically Mutable Matrices: A Hierarchical Investigation of Decellularized Sea Cucumber Collagen as an Adaptable Scaffold Material

Advanced Functional Materials, EarlyView.
Sea cucumber mutable collagenous tissue (MCT) is a remarkable collagen‐based material which can rapidly undergo large changes in stiffness through transiently bound effector proteins. Here, we investigate the hierarchical structure and mechanical response of MCT from Cucumaria frondosa across length scales with a wide range of methods, also exploring ...
Nathalie R. H. Singh, Amy K. Lin, Sabra Rostami, Cameron Hastie, Paul W. Wiseman, Patrick Flammang, Christopher Moraes, Matthew J. Harrington   +7 more
wiley   +1 more source

Human Dermal Stem/Progenitor Cell-Derived Conditioned Medium Improves Senescent Human Dermal Fibroblasts [PDF]

International Journal of Molecular Sciences, 2015
Adult skin stem cells are recognized as potential therapeutics to rejuvenate aged skin. We previously demonstrated that human dermal stem/progenitor cells (hDSPCs) with multipotent capacity could be enriched from human dermal fibroblasts using collagen type IV. However, the effects of hDSPCs on cellular senescence remain to be elucidated.
Jung, Ji-Yong, Shim, Joong, Choi, Hyun, Lee, Tae, Shin, Dong   +4 more
openaire   +3 more sources

Snap‐Through–Driven Liquid Crystal Elastomers for High‐Power Remote Microneedle Actuation Toward Smart Livestock Systems

Advanced Functional Materials, EarlyView.
A magnetically assisted snap‐through liquid crystal elastomer transforms photochemical deformation into a high‐power mechanical impulse, enabling remote microneedle actuation and highlighting its potential for future smart livestock intervention systems.
Chae Won Lee, Nankyung Kim, SeungHyun Park, Dae Seok Kim   +3 more
wiley   +1 more source