Results 131 to 140 of about 428,492 (343)

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source

HDL Promotes Rapid Atherosclerosis Regression in Mice and Alters Inflammatory Properties of Plaque Monocyte-Derived Cells [PDF]

, 2011
Jonathan E. Feig, Rong Jiang, Ronen Shamir   +2 more
openalex   +1 more source

Adipocytes in Aortic Stenosis: Association With Clinical and Morphological Indices

Clinical Anatomy, EarlyView.
ABSTRACT Recently, great attention has been given to understanding the new pathogenetic mechanisms underlying aortic stenosis (AS). The study aims to understand the role of mature adipocytes in AS and their association with histologic, clinical, and echocardiographic data, an area previously overlooked in AS research.
Elena Zoico, Tanaz Saatchi, Silvia Urbani, Vanni Rizzatti, Gloria Mazzali, Francesco Fantin, Silvia Faccioli, Alessandro Gavras, Mauro Zamboni, Anna Giani   +9 more
wiley   +1 more source

Lipid Profile Differences in HIV‐Infected Populations With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Systematic Review and Meta‐Analysis

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA study flow diagram. ABSTRACT Introduction Advances in HIV management have transformed HIV into a chronic condition, resulting in improved prognosis and increased survival among people living with HIV (PLWH). Traditional risk factors for metabolic dysfunction‐associated steatotic liver disease (MASLD)—including dyslipidemia—are prevalent in PLWH.
Yovita Hartantri, Sherly Lawrensia, Steven Yulius Usman, Nenny Agustanti, Rudi Wisaksana, Nanny Natalia Mulyani Soetedjo, Bachti Alisjahbana   +6 more
wiley   +1 more source

Plasminogen Activator Inhibitor-2 Polymorphism Associates with Recurrent Coronary Event Risk in Patients with High HDL and C-Reactive Protein Levels

, 2013
James P. Corsetti, Peter Salzman, Dan Ryan, Arthur J. Moss, Wojciech Zaręba, Charles E. Sparks   +5 more
openalex   +2 more sources

Exploring the Anti‐Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Diabetes mellitus (DM) is a global health challenge with increasing prevalence rates, particularly in low‐ and middle‐income countries. Anthocyanins (ACs) are potential bioactive compounds found in various fruits and vegetables, attracting the attention of researchers due to their possible role in managing diabetes and its complications ...
Lakshay Panchal, Sangeeta Yadav, Akash Kumar, Tanbeer Kaur, Yashna Bawa, Sarvesh Rustagi, Rahul Mehra   +6 more
wiley   +1 more source

SAT0088 Hdl cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with subclinical atherosclerosis [PDF]

, 2017
Beatriz Tejera Segura, María Macía-Díaz, JDM Machado, Amartya De, Alejandra González‐Delgado, JM Olmos, José L. Hernández, Federico Díaz‐González, Miguel Á. González‐Gay, Iván Ferraz‐Amaro   +9 more
openalex   +1 more source

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

The Lancet, 2012
B. Voight, G. Peloso, M. Orho-Melander, R. Frikke-Schmidt, M. Barbalić, M. Jensen, G. Hindy, H. Hólm, E. Ding, T. Johnson, H. Schunkert, N. Samani, R. Clarke, J. Hopewell, John F. Thompson, Mingyao Li, G. Thorleifsson, C. Newton‐Cheh, K. Musunuru, J. Pirruccello, D. Saleheen, Li Chen, A. Stewart, A. Schillert, U. Thorsteinsdóttir, G. Thorgeirsson, Sonia S Anand, J. Engert, T. Morgan, J. Spertus, M. Stoll, K. Berger, N. Martinelli, D. Girelli, P. McKeown, C. Patterson, S. Epstein, J. Devaney, M. Burnett, V. Mooser, S. Ripatti, I. Surakka, M. Nieminen, J. Sinisalo, M. Lokki, M. Perola, A. Havulinna, U. de Faire, B. Gigante, E. Ingelsson, T. Zeller, P. Wild, P. D. de Bakker, O. Klungel, A. H. Maitland‐van der Zee, B. Peters, A. de Boer, D. Grobbee, P. Kamphuisen, V. Deneer, Clara C Elbers, N. Onland-Moret, M. Hofker, C. Wijmenga, W. Verschuren, J. Boer, Y. T. van der Schouw, A. Rasheed, P. Frossard, S. Demissie, C. Willer, R. Do, J. Ordovás, G. Abecasis, M. Boehnke, K. Mohlke, M. Daly, C. Guiducci, N. Burtt, Aarti Surti, Elena Gonzalez, S. Purcell, S. Gabriel, J. Marrugat, J. Peden, J. Erdmann, P. Diemert, C. Willenborg, I. König, M. Fischer, C. Hengstenberg, A. Ziegler, I. Buysschaert, D. Lambrechts, F. Van de Werf, K. Fox, N. E. El Mokhtari, Diana Rubin, J. Schrezenmeir, S. Schreiber, Arne S Schäfer, J. Danesh, S. Blankenberg, R. Roberts, R. McPherson, H. Watkins, A. Hall, K. Overvad, E. Rimm, E. Boerwinkle, A. Tybjaerg-hansen, L. Cupples, M. Reilly, O. Melander, P. Mannucci, D. Ardissino, D. Siscovick, R. Elosúa, K. Stefánsson, C. O’Donnell, V. Salomaa, D. Rader, L. Peltonen, S. Schwartz, D. Altshuler, S. Kathiresan   +125 more
semanticscholar   +1 more source

Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice

ChemMedChem, EarlyView.
A low‐toxicity bioactive composition of oxidovanadium(IV) and exopolysaccharide levan is synthesized, characterized, and shown to reduce hyperglycemia, hypertriglyceridemia, and TyG index in a mice model of dexamethasone‐induced insulin resistance. Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more ...
Amanda K. J. P. F. da Silva, Eucilene K. de L. B. Marques, Lidiane M. A. de Lima, Widarlane A. S. Alves, Dayane A. Gomes, Pedro L. Guzzo, Mônica F. Belian, Wagner E. Silva, Eduardo C. Lira   +8 more
wiley   +1 more source