Results 21 to 30 of about 159,686 (49)

Serum amyloid A impairs the antiinflammatory properties of HDL.

Journal of Clinical Investigation, 2016
HDL from healthy humans and lean mice inhibits palmitate-induced adipocyte inflammation; however, the effect of the inflammatory state on the functional properties of HDL on adipocytes is unknown.
C. Han, Chongren Tang, M. E. Guevara, Hao Wei, T. Wietecha, Baohai Shao, S. Subramanian, M. Omer, Shari Wang, K. O’Brien, S. Marcovina, T. Wight, T. Vaisar, M. de Beer, F. C. de Beer, W. Osborne, K. Elkon, A. Chait   +17 more
semanticscholar   +2 more sources

Structure of HDL: particle subclasses and molecular components.

Handbook of Experimental Pharmacology, 2015
A molecular understanding of high-density lipoprotein (HDL) will allow a more complete grasp of its interactions with key plasma remodelling factors and with cell-surface proteins that mediate HDL assembly and clearance.
A. Kontush, M. Lindahl, M. Lhomme, L. Calabresi, M. Chapman, W. Davidson   +5 more
semanticscholar   +1 more source

The Changing Face of HDL and the Best Way to Measure It.

Clinical Chemistry, 2017
BACKGROUND HDL cholesterol (HDL-C) is a commonly used lipid biomarker for assessing cardiovascular health. While a central focus has been placed on the role of HDL in the reverse cholesterol transport (RCT) process, our appreciation for the other ...
S. Karathanasis, L. Freeman, S. Gordon, A. Remaley   +3 more
semanticscholar   +1 more source

Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus

PLoS ONE, 2016
Objectives To explore the association between the triglyceride to HDL-C ratio (TG/HDL-C) and insulin resistance in Chinese patients with newly diagnosed type 2 diabetes mellitus. Methods Patients with newly diagnosed type 2 diabetes mellitus (272 men and
Xingxing Ren, Z. Chen, Shuang Zheng, T. Han, Yang-xue Li, W. Liu, Yao-min Hu   +6 more
semanticscholar   +1 more source

HDL particle number and size as predictors of cardiovascular disease

Frontiers in Pharmacology, 2015
Previous studies indicate that reduced concentrations of circulating high-density lipoprotein (HDL) particles can be superior to HDL-cholesterol (HDL-C) levels as a predictor of cardiovascular disease.
A. Kontush
semanticscholar   +1 more source

The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status

Lipids in Health and Disease, 2016
Triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C) ratio was a surrogate marker of IR; however, the relationship of TG/HDL-C with IR might vary by ethnicity. This study aims to investigate whether lipid ratios-TG/HDL-C, cholesterol/high-density
Mei‐cen Zhou, Li-xia Zhu, Xiangli Cui, Linbo Feng, Xuefeng Zhao, Shuli He, F. Ping, Wei Li, Yuxiu Li   +8 more
semanticscholar   +1 more source

Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity[S]

Journal of Lipid Research, 2015
Recent studies demonstrate that HDL’s ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL’s major protein. However, the mechanisms that impair
T. Vaisar, Chongren Tang, I. Babenko, Patrick M. Hutchins, Jake Wimberger, A. Suffredini, J. Heinecke   +6 more
semanticscholar   +1 more source

HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the Lipoprotein Investigators Collaborative.

European Heart Journal, 2015
AIMS High-density lipoprotein (HDL) is highly heterogeneous and the link of its subclasses to prognosis remains controversial. We aimed to rigorously examine the associations of HDL subclasses with prognosis in secondary prevention.
S. Martin, A. Khokhar, H. May, K. Kulkarni, M. Blaha, P. Joshi, P. Toth, J. Muhlestein, Jeffrey L. Anderson, S. Knight, Yan Li, J. Spertus, S. Jones   +12 more
semanticscholar   +1 more source

Antioxidant properties of HDL

Frontiers in Pharmacology, 2015
High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly, HDL actually metabolizes lipid hydroperoxides preventing their accumulation
H. Soran, J. Schofield, P. Durrington
semanticscholar   +1 more source

Dysfunctional HDL and atherosclerotic cardiovascular disease

Nature Reviews Cardiology, 2016
R. Rosenson, H. Brewer, B. Ansell, P. Barter, M. Chapman, J. Heinecke, A. Kontush, A. Tall, N. Webb   +8 more
semanticscholar   +1 more source