Results 1 to 10 of about 27,753 (199)

High Prevalence of Active HDV Infection Among HBsAg-Positive Patients in Urban and Rural Areas in Gabon: A Cross-Sectional Retrospective Study. [PDF]

Health Sci Rep
ABSTRACT Background HDV, a defective virus dependent on hepatitis B for assembly, can lead to severe liver diseases and an increased risk of progressing to complications such as hepatocellular carcinoma. Given the high prevalence of HDV in Gabon, especially in central Africa, understanding the epidemiology and associated risks is crucial.
Bivigou-Mboumba B, Bignoumba M, Moussavou-Boundzanga P, Missoni Manga EL, Gafou A, Mouanga Ndzime Y, Wora DM, Akombi LF, Olembi JLZ, Ndjila RMB, Bisseye C, Mouinga Ondeme A, Onanga R, Pineau P.   +13 more
europepmc   +2 more sources

Trends of Advanced Chronic Liver Disease Among 17,711 Persons in Mongolia During Years 2015-2023. [PDF]

J Viral Hepat
ABSTRACT Chronic liver diseases cause a significant burden in Asia. This study aims to characterise the pattern and factors associated with advanced chronic liver disease (aCLD) in a large cohort from Mongolia, which has the highest rate of liver cancer globally.
Kamal H, Jargalsaikhan G, Enkhtaivan S, Bruce D, Lindahl K, Dashtseren B, Ulziibadrakh T, Batkhuu M, Bat-Ulzii P, Byambabaatar S, Aleman S, Dashdorj NB.   +11 more
europepmc   +2 more sources

Unexpectedly low prevalence of hepatitis delta virus infection in Southern Viet Nam [PDF]

Scientific Reports
Viet Nam faces a significant burden of viral hepatitis-associated liver disease, but the contribution of HDV, the most severe form of viral hepatitis, remains underinvestigated.
Thuy Nguyen, Van Huy Vo, Long Le, An Bac Luong, Chuong Dinh Nguyen, Phong Tien Quach, Thuy Thi-Thanh Trinh, Sang The Phan, Tuan Ngoc Cao, Thi Bich Chi Mai, Vu Anh Hoang, Hoang Huu Bui, Frank Maldarelli   +12 more
doaj   +2 more sources

Ten-Year Follow-Up After 96 Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT-II): Improved Clinical Outcome After Combination Therapy. [PDF]

United European Gastroenterol J
ABSTRACT Background Chronic delta hepatitis represents a major health burden. Until recently, pegylated interferon‐alfa‐2a (PEG‐IFNα) therapy was the only treatment option for patients infected with hepatitis D virus (HDV). The aim of this study was to evaluate 10‐year long‐term clinical and virological outcomes after 96 weeks of treatment with PEG ...
Yurdaydin C, Kahlhöfer J, Caruntu FA, Yalcin K, Gürel S, Akarca US, Sprinzl K, Bock HH, Bockmann JH, Papatheodoridis GV, Merle U, Demir M, Hardtke S, Keskin O, Idilman R, Cornberg M, Wedemeyer H, Wranke A.   +17 more
europepmc   +2 more sources

Multimodal characterization of the responsiveness of eight hepatitis D virus genotype isolates to interferon-alpha treatment [PDF]

Journal of Virology
Chronic hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis. Although humans produce 12 subtypes of interferon-alpha (IFN-α), IFN-α2a has been the only commonly used treatment against HDV.
Yibo Ding, Qiudi Li, Yunlu Sha, Ruilin Si, Chengqian Feng, Mei Liu, Zhanghao Feng, Xutong Ding, Ying Li, Huiyuan Fu, Shiquan Liang, Qili Yao, Zhenfeng Zhang, Feng Li, Stephan Urban, Hongbo Guo, Wenshi Wang   +16 more
doaj   +2 more sources

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]

, 2021
Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G, Frelin, L, Jagya, N, Johansson, M, Maravelia, P, Meuleman, Philip, Ni, Y, Pasetto, A, Pater, L, Pérez, NC, Sällberg, M, Urban, S, Verch, G, Verhoye, Lieven   +13 more
core   +1 more source

Results of HDV RNA detection in male seminal fluid and female cervical swab samples using RT-PCR

Proceedings of the Mongolian Academy of Sciences, 2023
Mongolia has an extremely high prevalence of hepatitis D virus (HDV), which leads to increased morbidity and mortality from hepatocellular carcinoma (HCC). HDV is the most severe form of chronic viral hepatitis (CVH).
Saruul Enkhjargal, Oyungerel Lkhagva-Ochir, Anir Enkhbat, Naranjargal Dashdorj, Nyamtsengel `Vangan, Odgerel Oidovsambuu   +5 more
doaj   +1 more source

Strain-specific responsiveness of hepatitis D virus to interferon-alpha treatment

JHEP Reports, 2023
Background & Aims: Pegylated interferon alpha (pegIFNα) is commonly used for the treatment of people infected with HDV. However, its mode of action in HDV-infected cells remains elusive and only a minority of people respond to pegIFNα therapy. Herein,
Katja Giersch, Paulina Perez-Gonzalez, Lennart Hendricks, Nora Goldmann, Jonathan Kolbe, Lennart Hermanussen, Jan-Hendrick Bockmann, Tassilo Volz, Annika Volmari, Lena Allweiss, Joerg Petersen, Dieter Glebe, Marc Lütgehetmann, Maura Dandri   +13 more
doaj   +1 more source

Unbranched rod-like RNA is required for RNA editing of hepatitis delta virus genotype 2 and genotype 4

Virus Research, 2023
RNA editing of the hepatitis delta virus (HDV) is essential for generating the large delta antigen, which is crucial for virion assembly. In HDV genotype 1 (HDV-1), editing occurs within the context of the unbranched rod-like structure characteristic of ...
Chao-Wei Hsu, Hsueh-Ying Hsu, Chien-Hung Chen, Mei Chao   +3 more
doaj   +1 more source

Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice

Frontiers in Microbiology, 2021
BackgroundHepatitis D Virus (HDV) is classified into eight genotypes with distinct clinical outcomes. Despite the maintenance of highly conserved functional motifs, it is unknown whether sequence divergence between genotypes, such as HDV-1 and HDV-3, or ...
Katja Giersch, Lennart Hermanussen, Tassilo Volz, Annika Volmari, Lena Allweiss, Lena Allweiss, Camille Sureau, John Casey, Jiabin Huang, Nicole Fischer, Marc Lütgehetmann, Marc Lütgehetmann, Maura Dandri, Maura Dandri   +13 more
doaj   +1 more source