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HDV evolution—will viral resistance be an issue in HDV infection?

Current Opinion in Virology, 2018
Hepatitis D virus (HDV) is a hepatotropic subviral infectious agent, obligate satellite of the Hepatitis B virus (HBV) and is highly related to viroids. HDV affects around 5% of the 257 million chronic HBV-carriers worldwide, leading to the most severe form of chronic viral hepatitis.
David Tabernero   +3 more
openaire   +2 more sources

Immunology of HDV Infection

2006
Hepatitis delta virus (HDV) infection may occur as coinfection with hepatitis B virus (HBV) or as superinfection of a chronically HBV-infected patient. A strong antibody response is mounted, which persists for many years; however, it is not able to modulate the course of infection. In most cases the superinfection takes a chronic course.
M, Fiedler, M, Roggendorf
openaire   +2 more sources

HDV Ribozymes

2006
The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants.
openaire   +2 more sources

HDV infection in immigrant populations

Journal of Medical Virology, 2019
AbstractAimsLittle data have been published so far on the epidemiological aspects of hepatitis D virus (HDV) infection in immigrant populations and even poorer is the information on the virological, phylogenetic, and clinical aspects of this infection in these populations.
Coppola N.   +5 more
openaire   +2 more sources

Significance of IgM anti‐hepatitis D virus (HDV) in chronic HDV infection

Journal of Medical Virology, 1991
AbstractIntrahepatic hepatitis D virus (HDV) antigen (HDAg) and serum HDV RNA are excellent markers of active HDV replication but the relation of IgM anti‐HDV to HDV replication and histological activity is less certain. To further elucidate the significance of serum IgM anti‐HDV, 90 paired sera and liver biopsies from 64 patients sero‐positive for ...
J Y, Lau   +6 more
openaire   +2 more sources

Target-Induced SOFA-HDV Ribozyme

2012
Small cis-acting ribozymes have been converted into trans-acting ribozymes possessing the ability to cleave RNA substrates. The Hepatitis Delta Virus (HDV) ribozyme is one of the rare examples of these that is derived from an RNA species that is found in human cells.
Michel V, Lévesque   +1 more
openaire   +2 more sources

The Woodchuck Model of HDV Infection

2006
The Eastern woodchuck, Marmota monax, has been a useful model system for the study of the natural history of hepadnavirus infection and for the development and preclinical testing of antiviral therapies. The model has also been used for hepatitis delta virus (HDV).
J L, Casey, J L, Gerin
openaire   +2 more sources

HBV/HDV COINFECTION

The Lancet, 1987
F. Caredda   +3 more
openaire   +3 more sources

The Use of Hepatocytes to Investigate HDV Infection: The HDV/HepaRG Model

2010
Worldwide, it is estimated that more than 350 million people are chronically infected with hepatitis B virus (HBV), approximately 15 million of whom are coinfected with hepatitis D virus (HDV), a satellite of HBV that uses the envelope proteins of the latter to assemble its infectious particles.
openaire   +2 more sources

Dynamic changes of HDV-RNA in HDV chronic inferction

Journal of Hepatology, 1989
M. Melero   +4 more
openaire   +1 more source

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