Results 51 to 60 of about 28,557 (262)

Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6

Frontiers in Pharmacology, 2019
While selective overexpression of serum clinical biomarker Human epididymis secretory protein 4 (HE4) is indicative of ovarian cancer tumorigenesis, much is still known about the mechanistic role of the HE4 gene or gene product. Here, we examine the role
Nicole E. James, Nicole E. James, Matthew T. Oliver, Jennifer R. Ribeiro, Evelyn Cantillo, Rachael B. Rowswell-Turner, Kyu-Kwang Kim, Clinton O. Chichester, Paul A. DiSilvestro, Richard G. Moore, Rakesh K. Singh, Rakesh K. Singh, Naohiro Yano, Naohiro Yano, Ting C. Zhao   +14 more
doaj   +1 more source

Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells

Frontiers in Pharmacology, 2021
Decreased human epididymis protein 4 (HE4) plasma levels were reported in cystic fibrosis (CF) patients under CFTR potentiator ivacaftor therapy, which inversely correlated with lung function improvement.
Zsolt Bene, Zsolt Bene, Zsolt Bene, Zsolt Fejes, Zsolt Fejes, Tibor Gabor Szanto, Ferenc Fenyvesi, Judit Váradi, Luka A. Clarke, Gyorgy Panyi, Milan Macek, Margarida D. Amaral, István Balogh, István Balogh, Béla Nagy, Béla Nagy   +15 more
doaj   +1 more source

Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4

Therapeutic Advances in Medical Oncology
Ovarian cancer (OC) is the most lethal gynaecologic malignancy, attributed to its insidious growth, non-specific symptoms and late presentation. Unfortunately, current screening modalities are inadequate at detecting OC and many lack the appropriate ...
Aruni Ghose, Lucy McCann, Shania Makker, U. Mukherjee, Srikar Gullapalli, Jayaraj Erekkath, Stephanie Shih, Ishika Mahajan, Elisabet Sánchez, Mario Uccello, M. Moschetta, S. Adeleke, S. Boussios   +12 more
semanticscholar   +1 more source

Serum CA125 and HE4 as Biomarkers for the Detection of Endometrial Cancer and Associated High-Risk Features

Diagnostics, 2022
Early detection of endometrial cancer improves survival. Non-invasive diagnostic biomarkers would improve triage of symptomatic women for investigations.
Chloe E. Barr, K. Njoku, Eleanor R. Jones, E. Crosbie   +3 more
semanticscholar   +1 more source

Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors

Diagnostics, 2022
(1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO).
Núria Carreras-Dieguez, A. Glickman, M. Munmany, G. Casanovas, N. Agustí, B. Diaz-Feijoo, A. Saco, Beatriz Sánchez, Lydia Gaba, M. Ángeles, J. Pahisa, E. Fernández-Galán, A. Torné, P. Fusté   +13 more
semanticscholar   +1 more source

Large-space cluster model calculations for the He3(He3,2p)He4 and H3(H3,2n)He4 reactions

, 1998
The He3(He3,2p)He4 and H3(H3,2n)He4 reactions are studied in a microscopic cluster model. We search for resonances in the He3+He3 and He4+p+p channels using methods that treat the two- and three-body resonance asymptotics correctly. Our results show that
Abdurashitov, Agnew, Aguilar, Angulo, Anselmann, Aoyama, Aoyama, Arpesella, Assenbaum, Attila Csótó, Austern, Bahcall, Bahcall, Balslev, Bang, Blüge, Brown, Castellani, Csótó, Csótó, Csótó, Csótó, Danilin, Danilin, Davis, Descouvemont, Dwarakanath, Ershov, Fetisov, Fowler, Govorov, Hata, Jarmie, Junker, Jänecke, Kamimura, Karlheinz Langanke, Katō, Krauss, Langanke, Prati, Raghavan, Reichstein, Serov, Shoppa, Simon, Suzuki, Thompson, Turck-Chièze, Typel   +49 more
core   +1 more source

HE4 and CA125 serum biomarker monitoring in women with epithelial ovarian cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2022
BACKGROUND CA125 is the gold standard serum biomarker for monitoring patients with epithelial ovarian cancer (EOC). Human epididymal protein 4 (HE4) is a novel serum biomarker for EOC patients.
A. Samborski, M. Miller, A. Blackman, S. MacLaughlan-David, A. Jackson, G. Lambert-Messerlian, Rachel Rowswell-Turner, Richard G. Moore   +7 more
semanticscholar   +1 more source

HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

BMC Cancer, 2022
Background To evaluate the diagnostic value of adding human epididymis protein 4 (HE4), cancer antigen 125 (CA125) and risk of malignancy algorithm (ROMA) to ultrasound for detecting ovarian cancer in patients with a pelvic mass.
E. Braicu, C. Krause, U. Torsten, H. Mecke, R. Richter, L. Hellmeyer, M. Lanowska, B. Müller, E. Koch, Janine Boenneß-Zaloum, K. Ames, R. Chekerov, K. Hasenbein, M. Zimmermann, M. Mangler, Frank Chen, Rudolf Tauber, J. Sehouli   +17 more
semanticscholar   +1 more source

Evaluation of human epididymal secretory protein 4 expression according to the molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2-positive, triple-negative) of breast cancer

Indian Journal of Pathology and Microbiology, 2018
Background/Aims: Human epididymal secretory protein 4 (HE4) is originally described as an epididymis-specific protein but more recently suggested to be a putative serum tumor marker for some tumors, including breast carcinomas. In this study, we aimed to
Gamze Akoz, Gulden Diniz, Sumeyye Ekmekci, Zubeyde Yildirim Ekin, Melek Uncel   +4 more
doaj   +1 more source

Elevated serum levels of human epididymis protein 4 in adult patients with proliferative lupus nephritis

Frontiers in Immunology, 2023
BackgroundThis study aimed to access whether serum human epididymis protein 4 (HE4) level could identify lupus nephritis (LN) pathological classes in adults and children.MethodsThe serum HE4 levels of 190 healthy subjects and 182 patients with systemic ...
Liubing Li, Huiya Xu, Yuting Le, Runzhao Li, Qiong Shi, Hongji Zhu, Hongxu Xu, Laisheng Li, Min Liu, Fen Wang, Hui Zhang, Hui Zhang   +11 more
doaj   +1 more source