Results 91 to 100 of about 584,381 (304)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of control strategies for wind-assisted ships on energy consumption

Brodogradnja
Wind-assisted ship propulsion is one of the solutions for reducing greenhouse gas emissions by generating additional thrust using renewable wind power.
Cem Guzelbulut, Timoteo Badalotti, Katsuyuki Suzuki   +2 more
doaj   +1 more source

Unmanned surface vessel heading control of model-free adaptive method with variable integral separated and proportion control

International Journal of Advanced Robotic Systems, 2019
Based on model-free adaptive control theory, the heading control problem of unmanned surface vessels under uncertain influence is explored. Firstly, the problems of compact form dynamic linearization model-free adaptive control method applied to unmanned
Quanquan Jiang, Yulei Liao, Ye Li, Yugang Miao, Wen Jiang, Changsheng Cheng   +5 more
doaj   +1 more source

The measurement of driver describing functions in simulated steering control tasks [PDF]

Measurements of driver describing functions in steering control tasks have been made using a driving simulator. The task was to regulate against a random crosswind gust input on a straight roadway, in order to stay in the center of the lane.
Weir, D. H., Wojcik, C. K.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Wheelchair control by head motion

Serbian Journal of Electrical Engineering, 2013
Electric wheelchairs are designed to aid paraplegics. Unfortunately, these can not be used by persons with higher degree of impairment, such as quadriplegics, i.e. persons that, due to age or illness, can not move any of the body parts, except of the head. Medical devices designed to help them are very complicated, rare and expensive.
Aleksandar Pajkanovic, Branko Dokic
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Self-Tuning Variable Universe Fuzzy PID Control Framework with Hybrid BAS-PSO-SA Optimization for Unmanned Surface Vehicles

Journal of Marine Science and Engineering
In this study, a hybrid heading control framework for unmanned surface vehicles (USVs) is proposed, combining variable domain fuzzy Proportional–Integral–Derivative (VUF-PID) with an improved algorithmic Beetle Antennae Search–Particle Swarm Optimization–
Huixia Zhang, Zhao Zhao, Yuchen Wei, Yitong Liu, Wenyang Wu   +4 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Heading in soccer increases serum neurofilament light protein and SCAT3 symptom metrics

BMJ Open Sport & Exercise Medicine, 2018
Objectives To determine the effect of heading a soccer ball on serum neurofilament light (NF-L) protein, plasma tau protein and symptom metrics including total number of symptoms reported and symptom severity scores on the Standardized Concussion ...
Colin Wallace, Jonathan D Smirl, Henrik Zetterberg, Kaj Blennow, Kelsey Bryk, Joel Burma, Jill Dierijck, Alexander David Wright, Paul van Donkelaar   +8 more
doaj   +1 more source