Results 71 to 80 of about 584,381 (304)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Hierarchical Control for Head-to-Head Autonomous Racing

Field Robotics
We develop a hierarchical controller for head-to-head autonomous racing. We first introduce a formulation of a racing game with realistic safety and fairness rules. A high-level planner approximates the original formulation as a discrete game with simplified state, control, and dynamics to easily encode the complex safety and fairness rules and ...
Rishabh Saumil Thakkar, Aryaman Singh Samyal, David Fridovich-Keil, Zhe Xu, Ufuk Topcu   +4 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A novel active disturbance rejection control with hyperbolic tangent function for path following of underactuated marine surface ships

Measurement + Control, 2020
This paper presents a TADRC method via active disturbance rejection control (ADRC) with hyperbolic tangent function for path following of underactuated surface ships with input constraint, heading rate constraint, parameters uncertainties, as well as ...
Ronghui Li, Baozhu Jia, Shaoyong Fan, Xinxiang Pan   +3 more
doaj   +1 more source

Genetic dissection of photoperiod response based on GWAS of pre-anthesis phase duration in spring barley [PDF]

, 2014
Heading time is a complex trait, and natural variation in photoperiod responses is a major factor controlling time to heading, adaptation and grain yield.
A Tondelli, A Turner, Ahmad M. Alqudah, AM Alqudah, Andreas Graner, B Trevaskis, Benjamin Kilian, Chengdao Li, D Fu, DA Laurie, EJ van den Oord, F Andres, G Borràs, G Borràs-Gelonch, G Borràs-Gelonch, G Haseneyer, H Nishida, I Karsai, J Cockram, J Cockram, J Comadran, JA Higgins, JC Zadoks, JD Storey, JK Pritchard, K Ikeda-Kawakatsu, L Bullrich, L Yan, M Mascher, MC Casao, MC Casao, MD Purugganan, MM Alonso-Peral, MN Hemming, N Sreenivasulu, NN Rao, OT Bonnett, P Gawronski, P Szucs, R Nitcher, R Waugh, Raj K. Pasam, Rajiv Sharma, RE Voorrips, RK Pasam, RP Dunford, S Faure, S Fujiwara, S Griffiths, S Stracke, SN Oliver, Thorsten Schnurbusch   +51 more
core   +5 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The effect of grass genotype and spring management on the nutritive value of mid-summer ryegrass swards [PDF]

, 2008
End of project reportThe objective of this project was to investigate the environmental, morphological and management factors that control reproductive initiation and development in Lolium perenne L. (perennial ryegrass) and their influence on mid-season
Gilliland, Trevor, Hurley, Grainne, O'Donovan, Michael   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Robust Adaptive Heading Control for a Ray-Type Hybrid Underwater Glider with Propellers

Journal of Marine Science and Engineering, 2019
This paper presents the modeling of a new ray-type hybrid underwater glider (RHUG) and an experimental approach used to robustly and adaptively control heading motion.
Ngoc-Duc Nguyen, Hyeung-Sik Choi, Sung-Wook Lee   +2 more
doaj   +1 more source