Results 51 to 60 of about 60,284 (266)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Analysis of Unmanned Surface Vehicles Heading KF-Based PI-(1+PI) Controller Using Improved Spider Wasp Optimizer

Drones
This paper proposes a Kalman filter-based cascaded PI-(1+PI) controller, optimized using an Improved Spider Wasp Optimizer (ISWO), to address the challenges of USV heading control in dynamic marine environments.
Xiaoyu Li, Xiangye Zeng, Jingyi Wang, Qi Li, Baoshuo Fan, Qi Zeng   +5 more
doaj   +1 more source

Heading control method of unmanned sailing boats based on fuzzy PID

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] In order to improve the anti-jamming ability and navigation stability of the unmanned sailing boats in the changeable and unknown environment and to realize accurate control of the heading of sailing boats,a fuzzy adaptive control method ...
Zhang Xuefei, Yuan Peng, Tan Junzhe, Wang Shujie, Xu Hongshen, Sun Ye   +5 more
doaj   +1 more source

Modified Kalman filter-based model predictive control for ship heading control with probabilistic constraints

Systems Science & Control Engineering, 2021
In this paper, the Modified Kalman Filter-Based Model Predictive Control (Modified MPC-KF) algorithm is proposed to solve the ship heading control problem by considering the presence of noise in the system.
Subchan Subchan, Ahmad Maulana Syafii, Tahiyatul Asfihani, Dieky Adzkiya   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Comprehensive Review of Ship Automatic Rudder Technology: Development, Challenges, and Prospects

Journal of Marine Science and Engineering
Ship automatic rudder systems are critical to enhancing the precision, safety, and intelligence of modern navigation, which plays a significant role in optimizing vessel control, reducing crew workload, and improving operational efficiency.
Minjie Zheng, Qianqiang Chen, Daowei Yan, Yawei Zhang   +3 more
doaj   +1 more source

Ship Motion Control Based on AMBPS-PID Algorithm

IEEE Access, 2019
Intelligent motion control is one of the key technologies of ships. This paper studies the application of Adaptive Mutation Beetle Particle Swarm (AMBPS)-PID algorithm in ship motion control. Firstly, the ship MMG model is established.
Le Wang, Qing Wu, Jialun Liu, Shijie Li, Rudy R. Negenborn   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source