Results 41 to 50 of about 8,429 (258)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Headway Optimisation for Metro Lines Based on Timetable Simulation and Simulated Annealing

Journal of Advanced Transportation, 2022
To improve the capacity of metro systems, it is important to evaluate and minimise headway, which is defined as the time interval calculated from “head to head” between two successive trains in this paper.
Yong Cui, Qing Yu, Chenyang Wang
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Impact of a Non-Dedicated U-Turn on Traffic

Pakistan Journal of Engineering & Technology, 2020
Non-dedicated U turn has a direct effect on road safety, capacity and congestion during the traffic flow. U turn can have significant supremacy on traffic flow and headway. Therefore to study the impact of non-dedicated u turns on traffic is the ultimate
Muhammad Zeeshan Khan, Zawar Hussain Khan   +1 more
doaj   +5 more sources

Reliability Assessment of Vehicle-to-Vehicle Communication Networks through Headway Distribution and Information Propagation Delay

Transportation Research Interdisciplinary Perspectives
Several developed vehicle spaces and time headway distribution models in traffic flow theory have been widely used in the literature, reflecting the primary uncertainty in drivers’ car-following movements and explaining the traffic flow stochastic ...
Marzieh Khakifirooz, Michel Fathi, Lili Du   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Acceptability of Countdown Signals at an Urban Signalized Intersection and their Influence on Drivers Behaviour

Promet (Zagreb), 2013
There are different factors that affect driver’s behaviour at an urban signalized intersection. Complementary countdown signal heads can be used to inform the driver about the traffic light phase status.
Robert Rijavec, Jure Zakovšek, Tomaž Maher   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Improving the public transit system for routes with scheduled headways [PDF]

Yugoslav Journal of Operations Research, 2014
This research contributes to the improvement of the optimal headway solution for the transit performance functions (e. g., minimize total cost; maximize social welfare) derived from the traffic model proposed by Hendrickson.
Chuang Jones Pi-Chang, Chu Peter
doaj   +1 more source