Results 101 to 110 of about 6,640,377 (362)

An Interactive Curricula Experience (iCE) for Latino Immigrant Health [PDF]

, 2016
The Interactive Curricula Experience (iCE) is an educational platform intended for interactive education utilizing multiple forms of media. It is being utilized at Thomas Jefferson University (TJU) in various classes, among them Global Health. One of the
Ankeny, MEd, Martha Langley, Molyneux, Kevin, Plumb, MD, Ellen   +2 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Analysis of the Health Profile of Students Enrolled in High School at the Ouro Preto State School: a descriptive cross-sectional study

Revista Médica de Minas Gerais
Introduction: Adolescence is the stage between childhood and adulthood, characterized by physical, and mainly, psychological changes, which make this period full of new experiences and uncertainties, increasing the vulnerability of this group.
Daniela Fonseca Abdo Rocha, Gabriella Fagundes Carvalho Cabral, Paula de Almeida Silva, Ísis Eloah Machado, Eloisa Helena de Lima   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cultural and linguistic adaptation of stop the bleed: saving lives in a multi-ethnic refugee resettlement community

Health Literacy and Communication Open
Background Research and practice show an urgent need for health interventions to be adapted in culturally and linguistically responsive ways for limited English proficient (LEP) communities where cultural and language discordance exacerbate challenges in
Iris Feinberg, Randi N. Smith, Amy Zeidan, Deepika Kogonti, Kelleigh Dawn Trepanier, Stephanie Adrian, Mary Helen O’Connor   +6 more
doaj   +1 more source

Does Government Expenditure Affect Poverty, Health, and Education? Evidence from Aceh, Indonesia

, 2022
Arifka Yusri
openalex   +2 more sources

Perbedaan Tingkat Kecemasan Menghadapi Menarche Sebelum Dan Sesudah Diberikan Pendidikan Kesehatan Pada Siswi Kelas Vii Di Smp Negeri 46 Palembang [PDF]

, 2019
Background : Menarche is first menstruation experienced by teenagers aged 10- 16 and occurs in the mid period toward puberty phase. At this age, it is necessary for the teenagers to gain health education about Menarche so that the teenagers especially ...
Nita, Kadek
core  

LGBTQ+ Health-a Novel Course for Undergraduate Students. [PDF]

, 2020
The concept of providing focused, competency-based LGBTQ+ health education outside the setting of health professional programs, specifically for undergraduates, is quite uncharted.
Altneu, Eric, Clinchot, Daniel M, Davis, John A, Grieco, C Alexander, Verbeck, Nicole   +4 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source