Results 111 to 120 of about 8,431,854 (321)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Research and Humanities in Medical Education, 2020 DNAR stands for 'Do Not Attempt Resuscitation' which indicates that a person does not want to receive cardiopulmonary resuscitation or advanced medical care at the end of life when, in the specific case, the patient believes it may do more harm than good.
Kamna Kakkar
doaj
BMJ, 2000 News p 1178 Over the past few weeks England and Wales have endured the most widespread flooding for more than 50 years. By the end of the first week of November more than 3000 homes had been flooded and transport had been disrupted; in some areas water supplies have been contaminated, and a hospital has been evacuated.1 Flooding accounts for 40% of ...
C A, Ohl, S, Tapsell
openaire +3 more sources
Foundation Funding for the Humanities: An Overview of Current and Historical Trends [PDF]
, 2004 Foundation Funding for the Humanities: An Overview of Current and Historical Trends, finds that funding for fields such as art history, history and archeology, languages and linguistics, area studies, and the humanistic social sciences increased two and ...
Loren Renz, Steven Lawrence
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Practicing medicine in the COVID-19 Pandemic
Research and Humanities in Medical Education, 2021 Frontline clinicians have become society’s line of defence against a raging pandemic. Their stories reflect the uncertainty faced on a daily basis and are witness to their courageous acts first-hand.
Mariella Scerri, Victor E Grech
doaj
Which Factors Determine Academic Performance of Undergraduate Students in Economics?: Some Spanish Evidence [PDF]
, 2007 This paper analyses the determinants of academic performance of first-year undergraduate students in Economics at Universidad Carlos III de Madrid, over the period 2001-2005.
Dolado, Juan José, Morales, Eduardo
core +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Health Humanities in Medicina: The Auxiliary Stance. [PDF]
Medicina (Kaunas), 2022 Dammann O, Mežinska S, Gefenas E.
europepmc +1 more source