Results 41 to 50 of about 4,218,420 (254)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2010 Assesses the 2009 Health Information Technology for Economic and Clinical Health Act, which offers incentives to adopt and meaningfully use electronic health records.
Helen R. Pfister +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Role of Electronic Health Records in Presenting Health Information [PDF]
Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2012 Corrently any institute that does not benefit from information technology and communication networks, will gradually fall away from global communication.
Maryam Fakhrzad +2 more
doaj
Improved efficiency of coding systems with health information technology
Scientific Reports, 2021 This study aimed to investigate the impact of health information technology (IT) on the Case Mix Index (CMI). This study was a retrospective cohort study using hospital financial data from the Office of Statewide Health Planning and Development (OSHPD ...
Jinhyung Lee, Jae-Young Choi
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Effects of Health Information Technology on Malpractice Insurance Premiums [PDF]
Healthcare Informatics Research, 2015 ObjectivesThe widespread adoption of health information technology (IT) will help contain health care costs by decreasing inefficiencies in healthcare delivery.
Hye Yeong Kim, Jinhyung Lee
doaj +1 more source
Enhancing the Capacity of Community Health Centers to Achieve High Performance [PDF]
, 2010 Based on a survey of community health centers, assesses access to care, care coordination, quality improvement efforts, health information technology adoption, and ability to serve as patient-centered medical homes.
Anne C. Beal +4 more
core
Are HIV smartphone apps and online interventions fit for purpose? [PDF]
, 2017 Sexual health is an under-explored area of Human-Computer Interaction (HCI), particularly sexually transmitted infections such as HIV. Due to the stigma associated with these infections, people are often motivated to seek information online.
Brady M. +10 more
core +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source