Results 51 to 60 of about 1,225,681 (236)

Obstetric service demand is the main health need of the Vietnamese population in Guangxi, China: A cross-sectional study

Medicine
China has become an emerging destination for international migration, especially in some Association of South East Asian Nations countries, but the situation of migrants seeking medical care in China remains unclear. A retrospective cross-sectional study was conducted in a hospital in Chongzuo, which provides medical services for foreigners, to ...
Zhini Lan, Xiaoqiu Wu, Jiefang Huang, Cuizhu Pan, Jingzhen Lai, Xia Liang   +5 more
openaire   +2 more sources

The demand for health care in South Africa [PDF]

Supply-side solutions to health-care provision dominate the South African debate about health care. These solutions are often premised on views that health resources are too concentrated in the private health sector – which supposedly serves only a small
Roy Havemann, Servaas van der Berg
core  

Perceptions and Demand for Health Insurance services offered under National Health Insurance Fund (NHIF) Scheme among Civil Servants in Tanzania [PDF]

, 2017
This paper examines the perceptions and demand for health insurance services offered under NHIF scheme in Tanzania. It examines the perceptions of civil servants, the factors influencing perceptions and their implications to the demand for health ...
Kibambila, Vicent
core   +1 more source

Exploring the Feasibility of Service Integration in a Low-Income Setting: A Mixed Methods Investigation into Different Models of Reproductive Health and HIV Care in Swaziland. [PDF]

, 2015
Integrating reproductive health (RH) with HIV care is a policy priority in high HIV prevalence settings, despite doubts surrounding its feasibility and varying evidence of effects on health outcomes.
Alison Wringe, B Ekman, BG Glaser, CE Warren, CF Gilks, D Georgeu, D Grossman, D McCoy, F Dwamena, FE Harrell Jr., George B. Ploubidis, H Coovadia, H Schneider, HW Reynolds, J Shelton, JA Smit, JN Baumgartner, K Church, K Church, K Church, K Church, K Uebel, Kathryn Church, Kebede Deribe, L Lush, L Lush, L Myer, M Dixon-Woods, M Rabkin, M Sibide, ML Lindegren, N Leon, Phelele Fakudze, R Mutemwa, R Pawson, R Yin, S Reeves, S Reeves, Simon Lewin, SM Topp, Susannah H. Mayhew, WM El-Sadr   +41 more
core   +4 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Backcasting to identify food waste prevention and mitigation opportunities for infant feeding in the maternity services [PDF]

, 2017
peer-reviewedFood waste in hospitals is of major concern for two reasons: first, healthcare needs to move toward preventative and demand led models for sustainability and second, food system sustainability needs to seek preventative measures such as diet
Becker, Genevieve, Moles, Richard, O'Regan, Bernadette, Ryan-Fogarty, Yvonne   +3 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source