Results 61 to 70 of about 1,225,681 (236)

From "best practice" to "best fit": a framework for designing and analyzing pluralistic agricultural advisory services [PDF]

open access: yes
"Agricultural advisory services play an important role in supporting the use of the agricultural sector as an engine of pro-poor growth and enabling small farmers to meet new challenges, such as accessing export markets, adopting environmentally ...
Anandajayasekeram, Pooniah   +10 more
core  

How is the Region Doing? Human Service Use and Service Availability in Allegheny County, PA [PDF]

open access: yes, 2006
Allegheny County is home to approximately 1,600 financially-active nonprofit organizations, including 357 human service providers that deliver a range of health and social services.1 Past research has suggested that Pittsburgh's nonprofits, as a group ...
Elisa Bernd, Marcela Gutiarrez-Mayka
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Understanding the relationship between crime victimisation and mental health: a longitudinal analysis of population data [PDF]

open access: yes
Being a victim of violent crime has a damaging effect on mental health, particularly for women, according to this report. The needs and experiences of victims of crime have become increasingly recognised as an important aspect of criminal justice and ...
Karen Freeman, Nadine Smith
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Maternal health in Jamaica : health needs, services, and utilization [PDF]

open access: yes
The main health issues for Jamaican women are nutrition, fertility, infection, chronic diseases, and stress and social problems. The two leading causes of adult health for women are cerebro-vascular accidents and coronary heart disease - of which high ...
Feifer, Chris Naschak
core  

Experimental validation of an electrical and thermal energy demand model for health centers in sub-Saharan Africa [PDF]

open access: yes, 2017
peer reviewedSimulation of energy and building HVAC demand is a core engineering discipline, but practical applications for design tend to focus on buildings within urban environments and with usage modes established according to indoor comfort standards
Altes-Buch, Queralt   +3 more
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Big data logistics: a health-care transport capacity sharing model [PDF]

open access: yes, 2015
The growth of cities in the 21st century has put more pressure on resources and conditions of urban life. There are several reasons why the health-care industry is the focus of this investigation. For instance, in the UK various studies point to the lack
Graham, G, Mehmood, R
core   +1 more source

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